{
  "url": "https://dantelabs.com/traits/b-cell-lymphoma",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "b-cell-lymphoma",
    "id": "HP:0012191",
    "name": "B-cell lymphoma",
    "definition": "A type of lymphoma that originates in B-cells.",
    "synonyms": [
      "B cell lymphoma"
    ],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      },
      {
        "slug": "neoplasm",
        "name": "Abnormal tissue mass",
        "url": "https://dantelabs.com/traits/neoplasm"
      }
    ],
    "broader": [
      {
        "slug": "non-hodgkin-lymphoma",
        "name": "Non-Hodgkin lymphoma",
        "url": "https://dantelabs.com/traits/non-hodgkin-lymphoma"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "itpr3",
        "symbol": "ITPR3",
        "hgnc": "HGNC:6182",
        "name": "inositol 1,4,5-trisphosphate receptor type 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/itpr3"
      },
      {
        "slug": "magt1",
        "symbol": "MAGT1",
        "hgnc": "HGNC:28880",
        "name": "magnesium transporter 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/magt1"
      },
      {
        "slug": "nfatc2",
        "symbol": "NFATC2",
        "hgnc": "HGNC:7776",
        "name": "nuclear factor of activated T cells 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nfatc2"
      },
      {
        "slug": "ptprc",
        "symbol": "PTPRC",
        "hgnc": "HGNC:9666",
        "name": "protein tyrosine phosphatase receptor type C",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptprc"
      },
      {
        "slug": "rasgrp1",
        "symbol": "RASGRP1",
        "hgnc": "HGNC:9878",
        "name": "RAS guanyl releasing protein 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rasgrp1"
      },
      {
        "slug": "atm",
        "symbol": "ATM",
        "hgnc": "HGNC:795",
        "name": "ATM serine/threonine kinase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atm"
      },
      {
        "slug": "bcl10",
        "symbol": "BCL10",
        "hgnc": "HGNC:989",
        "name": "BCL10 immune signaling adaptor",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bcl10"
      },
      {
        "slug": "birc3",
        "symbol": "BIRC3",
        "hgnc": "HGNC:591",
        "name": "baculoviral IAP repeat containing 3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/birc3"
      },
      {
        "slug": "ccnd1",
        "symbol": "CCND1",
        "hgnc": "HGNC:1582",
        "name": "cyclin D1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccnd1"
      },
      {
        "slug": "foxp1",
        "symbol": "FOXP1",
        "hgnc": "HGNC:3823",
        "name": "forkhead box P1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/foxp1"
      },
      {
        "slug": "igh",
        "symbol": "IGH",
        "hgnc": "HGNC:5477",
        "name": "immunoglobulin heavy locus",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/igh"
      },
      {
        "slug": "malt1",
        "symbol": "MALT1",
        "hgnc": "HGNC:6819",
        "name": "MALT1 paracaspase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/malt1"
      },
      {
        "slug": "ikzf3",
        "symbol": "IKZF3",
        "hgnc": "HGNC:13178",
        "name": "IKAROS family zinc finger 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ikzf3"
      },
      {
        "slug": "itk",
        "symbol": "ITK",
        "hgnc": "HGNC:6171",
        "name": "IL2 inducible T cell kinase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/itk"
      },
      {
        "slug": "syk",
        "symbol": "SYK",
        "hgnc": "HGNC:11491",
        "name": "spleen associated tyrosine kinase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/syk"
      },
      {
        "slug": "casp10",
        "symbol": "CASP10",
        "hgnc": "HGNC:1500",
        "name": "caspase 10",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/casp10"
      },
      {
        "slug": "diaph1",
        "symbol": "DIAPH1",
        "hgnc": "HGNC:2876",
        "name": "diaphanous related formin 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/diaph1"
      },
      {
        "slug": "fas",
        "symbol": "FAS",
        "hgnc": "HGNC:11920",
        "name": "Fas cell surface death receptor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fas"
      },
      {
        "slug": "faslg",
        "symbol": "FASLG",
        "hgnc": "HGNC:11936",
        "name": "Fas ligand",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/faslg"
      },
      {
        "slug": "fcho1",
        "symbol": "FCHO1",
        "hgnc": "HGNC:29002",
        "name": "FCH and mu domain containing endocytic adaptor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fcho1"
      },
      {
        "slug": "nbn",
        "symbol": "NBN",
        "hgnc": "HGNC:7652",
        "name": "nibrin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nbn"
      },
      {
        "slug": "stat6",
        "symbol": "STAT6",
        "hgnc": "HGNC:11368",
        "name": "signal transducer and activator of transcription 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stat6"
      },
      {
        "slug": "pik3r1",
        "symbol": "PIK3R1",
        "hgnc": "HGNC:8979",
        "name": "phosphoinositide-3-kinase regulatory subunit 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pik3r1"
      },
      {
        "slug": "ada",
        "symbol": "ADA",
        "hgnc": "HGNC:186",
        "name": "adenosine deaminase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ada"
      }
    ]
  }
}