{
  "url": "https://dantelabs.com/traits/abnormal-t-cell-morphology",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-t-cell-morphology",
    "id": "HP:0002843",
    "name": "Abnormal T cell morphology",
    "definition": "Abnormal increase or decrease of total or subset T cell count. T cells are commonly characterized as CD3+ lymphocytes, or their subpopulations, in the blood, compared to a reference range for a given sex and age-group, measured ex vivo. These may include both TCR alpha/beta and gamma/delta T cells.",
    "synonyms": [
      "Abnormal T cells",
      "Abnormality of T cells",
      "Cellular immune defect",
      "Defective cellular immunity"
    ],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      },
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-lymphocyte-morphology",
        "name": "Abnormal lymphocyte morphology",
        "url": "https://dantelabs.com/traits/abnormal-lymphocyte-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "abnormal-t-cell-subset-number",
        "name": "Abnormal T cell subset number",
        "genes": 2,
        "url": "https://dantelabs.com/traits/abnormal-t-cell-subset-number"
      },
      {
        "slug": "abnormal-total-t-cell-number",
        "name": "Abnormal total T cell number",
        "genes": 2,
        "url": "https://dantelabs.com/traits/abnormal-total-t-cell-number"
      },
      {
        "slug": "abnormal-tcr-repertoire",
        "name": "Abnormal TCR repertoire",
        "genes": 1,
        "url": "https://dantelabs.com/traits/abnormal-tcr-repertoire"
      },
      {
        "slug": "decreased-cd4-t-cell-zap-70-protein-expression",
        "name": "Decreased CD4+ T cell ZAP-70 protein expression",
        "genes": 1,
        "url": "https://dantelabs.com/traits/decreased-cd4-t-cell-zap-70-protein-expression"
      },
      {
        "slug": "decreased-foxp3-expressing-t-cell-count",
        "name": "Decreased FOXP3-expressing T cell count",
        "genes": 1,
        "url": "https://dantelabs.com/traits/decreased-foxp3-expressing-t-cell-count"
      }
    ],
    "genes": [
      {
        "slug": "cd28",
        "symbol": "CD28",
        "hgnc": "HGNC:1653",
        "name": "CD28 molecule",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd28"
      },
      {
        "slug": "ctla4",
        "symbol": "CTLA4",
        "hgnc": "HGNC:2505",
        "name": "cytotoxic T-lymphocyte associated protein 4",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctla4"
      },
      {
        "slug": "pnp",
        "symbol": "PNP",
        "hgnc": "HGNC:7892",
        "name": "purine nucleoside phosphorylase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pnp"
      },
      {
        "slug": "tnfrsf1b",
        "symbol": "TNFRSF1B",
        "hgnc": "HGNC:11917",
        "name": "TNF receptor superfamily member 1B",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnfrsf1b"
      },
      {
        "slug": "cd4",
        "symbol": "CD4",
        "hgnc": "HGNC:1678",
        "name": "CD4 molecule",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd4"
      },
      {
        "slug": "smarcal1",
        "symbol": "SMARCAL1",
        "hgnc": "HGNC:11102",
        "name": "SNF2 related chromatin remodeling annealing helicase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smarcal1"
      }
    ]
  }
}