{
  "url": "https://dantelabs.com/traits/abnormal-renal-morphology",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "abnormal-renal-morphology",
    "id": "HP:0012210",
    "name": "Abnormally shaped kidney",
    "label": "Abnormal renal morphology",
    "definition": "Any structural anomaly of the kidney.",
    "synonyms": [
      "Kidney malformation",
      "Kidney structure issue",
      "Structural kidney abnormalities",
      "Abnormal kidney morphology",
      "Renal malformation",
      "Structural anomalies of the renal tract",
      "Structural renal anomalies"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-genitourinary-system",
        "name": "Abnormality of the genitourinary system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-genitourinary-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-the-kidney",
        "name": "Abnormality of the kidney",
        "url": "https://dantelabs.com/traits/abnormality-of-the-kidney"
      }
    ],
    "narrower": [
      {
        "slug": "kidney-stone",
        "name": "Kidney stone",
        "genes": 132,
        "url": "https://dantelabs.com/traits/kidney-stone"
      },
      {
        "slug": "renal-cyst",
        "name": "Cystic kidney disease",
        "genes": 129,
        "url": "https://dantelabs.com/traits/renal-cyst"
      },
      {
        "slug": "nephrocalcinosis",
        "name": "Increased calcium level in kidney",
        "genes": 97,
        "url": "https://dantelabs.com/traits/nephrocalcinosis"
      },
      {
        "slug": "renal-dysplasia",
        "name": "Renal dysplasia",
        "genes": 75,
        "url": "https://dantelabs.com/traits/renal-dysplasia"
      },
      {
        "slug": "renal-hypoplasia-aplasia",
        "name": "Absent/small kidney",
        "genes": 73,
        "url": "https://dantelabs.com/traits/renal-hypoplasia-aplasia"
      },
      {
        "slug": "enlarged-kidney",
        "name": "Enlarged kidney",
        "genes": 48,
        "url": "https://dantelabs.com/traits/enlarged-kidney"
      },
      {
        "slug": "abnormal-localization-of-kidney",
        "name": "Abnormal localisation of kidneys",
        "genes": 40,
        "url": "https://dantelabs.com/traits/abnormal-localization-of-kidney"
      },
      {
        "slug": "renal-duplication",
        "name": "Extra kidney",
        "genes": 36,
        "url": "https://dantelabs.com/traits/renal-duplication"
      },
      {
        "slug": "renal-steatosis",
        "name": "Fatty kidney",
        "genes": 11,
        "url": "https://dantelabs.com/traits/renal-steatosis"
      },
      {
        "slug": "renal-amyloidosis",
        "name": "Renal amyloidosis",
        "genes": 10,
        "url": "https://dantelabs.com/traits/renal-amyloidosis"
      },
      {
        "slug": "renal-malrotation",
        "name": "Abnormal rotation of the kidneys",
        "genes": 8,
        "url": "https://dantelabs.com/traits/renal-malrotation"
      },
      {
        "slug": "abnormal-renal-collecting-system-morphology",
        "name": "Abnormal renal collecting system morphology",
        "genes": 6,
        "url": "https://dantelabs.com/traits/abnormal-renal-collecting-system-morphology"
      },
      {
        "slug": "renal-atrophy",
        "name": "Kidney degeneration",
        "genes": 5,
        "url": "https://dantelabs.com/traits/renal-atrophy"
      },
      {
        "slug": "abnormal-renal-interstitial-morphology",
        "name": "Abnormal renal interstitial morphology",
        "genes": 2,
        "url": "https://dantelabs.com/traits/abnormal-renal-interstitial-morphology"
      },
      {
        "slug": "abnormal-renal-medulla-morphology",
        "name": "Abnormal renal medulla morphology",
        "genes": 2,
        "url": "https://dantelabs.com/traits/abnormal-renal-medulla-morphology"
      },
      {
        "slug": "nephrogenic-rest",
        "name": "Nephrogenic rest",
        "genes": 2,
        "url": "https://dantelabs.com/traits/nephrogenic-rest"
      },
      {
        "slug": "renal-fibrosis",
        "name": "Renal fibrosis",
        "genes": 2,
        "url": "https://dantelabs.com/traits/renal-fibrosis"
      },
      {
        "slug": "abnormal-renal-cortex-morphology",
        "name": "Abnormal renal cortex morphology",
        "genes": 1,
        "url": "https://dantelabs.com/traits/abnormal-renal-cortex-morphology"
      },
      {
        "slug": "nephrosclerosis",
        "name": "Scarring of kidney arteries",
        "genes": 1,
        "url": "https://dantelabs.com/traits/nephrosclerosis"
      },
      {
        "slug": "abnormal-nephron-morphology",
        "name": "Abnormal nephron morphology",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-nephron-morphology"
      },
      {
        "slug": "abnormal-renal-calyx-morphology",
        "name": "Abnormal renal calyx morphology",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-renal-calyx-morphology"
      },
      {
        "slug": "abnormal-renal-echogenicity",
        "name": "Abnormal renal echogenicity",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-renal-echogenicity"
      },
      {
        "slug": "abnormal-renal-pelvis-morphology",
        "name": "Abnormal renal pelvis morphology",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-renal-pelvis-morphology"
      },
      {
        "slug": "abnormal-renal-vascular-morphology",
        "name": "Abnormal renal vascular morphology",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-renal-vascular-morphology"
      },
      {
        "slug": "renal-necrosis",
        "name": "Renal necrosis",
        "genes": 0,
        "url": "https://dantelabs.com/traits/renal-necrosis"
      }
    ],
    "genes": [
      {
        "slug": "brca1",
        "symbol": "BRCA1",
        "hgnc": "HGNC:1100",
        "name": "BRCA1 DNA repair associated",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/brca1"
      },
      {
        "slug": "brca2",
        "symbol": "BRCA2",
        "hgnc": "HGNC:1101",
        "name": "BRCA2 DNA repair associated",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/brca2"
      },
      {
        "slug": "brip1",
        "symbol": "BRIP1",
        "hgnc": "HGNC:20473",
        "name": "BRCA1 interacting DNA helicase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/brip1"
      },
      {
        "slug": "eln",
        "symbol": "ELN",
        "hgnc": "HGNC:3327",
        "name": "elastin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/eln"
      },
      {
        "slug": "ercc4",
        "symbol": "ERCC4",
        "hgnc": "HGNC:3436",
        "name": "ERCC excision repair 4, endonuclease catalytic subunit",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ercc4"
      },
      {
        "slug": "faap100",
        "symbol": "FAAP100",
        "hgnc": "HGNC:26171",
        "name": "FA core complex associated protein 100",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/faap100"
      },
      {
        "slug": "fanca",
        "symbol": "FANCA",
        "hgnc": "HGNC:3582",
        "name": "FA complementation group A",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/fanca"
      },
      {
        "slug": "fancb",
        "symbol": "FANCB",
        "hgnc": "HGNC:3583",
        "name": "FA complementation group B",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fancb"
      },
      {
        "slug": "fancc",
        "symbol": "FANCC",
        "hgnc": "HGNC:3584",
        "name": "FA complementation group C",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fancc"
      },
      {
        "slug": "fancd2",
        "symbol": "FANCD2",
        "hgnc": "HGNC:3585",
        "name": "FA complementation group D2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fancd2"
      },
      {
        "slug": "fance",
        "symbol": "FANCE",
        "hgnc": "HGNC:3586",
        "name": "FA complementation group E",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fance"
      },
      {
        "slug": "fancf",
        "symbol": "FANCF",
        "hgnc": "HGNC:3587",
        "name": "FA complementation group F",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fancf"
      },
      {
        "slug": "fancg",
        "symbol": "FANCG",
        "hgnc": "HGNC:3588",
        "name": "FA complementation group G",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fancg"
      },
      {
        "slug": "fanci",
        "symbol": "FANCI",
        "hgnc": "HGNC:25568",
        "name": "FA complementation group I",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/fanci"
      },
      {
        "slug": "fancl",
        "symbol": "FANCL",
        "hgnc": "HGNC:20748",
        "name": "FA complementation group L",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fancl"
      },
      {
        "slug": "fancm",
        "symbol": "FANCM",
        "hgnc": "HGNC:23168",
        "name": "FA complementation group M",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fancm"
      },
      {
        "slug": "mad2l2",
        "symbol": "MAD2L2",
        "hgnc": "HGNC:6764",
        "name": "mitotic arrest deficient 2 like 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mad2l2"
      },
      {
        "slug": "mlxipl",
        "symbol": "MLXIPL",
        "hgnc": "HGNC:12744",
        "name": "MLX interacting protein like",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mlxipl"
      },
      {
        "slug": "palb2",
        "symbol": "PALB2",
        "hgnc": "HGNC:26144",
        "name": "partner and localizer of BRCA2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/palb2"
      },
      {
        "slug": "rad51",
        "symbol": "RAD51",
        "hgnc": "HGNC:9817",
        "name": "RAD51 recombinase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rad51"
      },
      {
        "slug": "rad51c",
        "symbol": "RAD51C",
        "hgnc": "HGNC:9820",
        "name": "RAD51 paralog C",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rad51c"
      },
      {
        "slug": "rai1",
        "symbol": "RAI1",
        "hgnc": "HGNC:9834",
        "name": "retinoic acid induced 1",
        "frequency": "frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/rai1"
      },
      {
        "slug": "rfwd3",
        "symbol": "RFWD3",
        "hgnc": "HGNC:25539",
        "name": "ring finger and WD repeat domain 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rfwd3"
      },
      {
        "slug": "slx4",
        "symbol": "SLX4",
        "hgnc": "HGNC:23845",
        "name": "SLX4 structure-specific endonuclease subunit",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slx4"
      },
      {
        "slug": "ube2t",
        "symbol": "UBE2T",
        "hgnc": "HGNC:25009",
        "name": "ubiquitin conjugating enzyme E2 T",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ube2t"
      },
      {
        "slug": "xrcc2",
        "symbol": "XRCC2",
        "hgnc": "HGNC:12829",
        "name": "X-ray repair cross complementing 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/xrcc2"
      },
      {
        "slug": "adgrg2",
        "symbol": "ADGRG2",
        "hgnc": "HGNC:4516",
        "name": "adhesion G protein-coupled receptor G2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/adgrg2"
      },
      {
        "slug": "cftr",
        "symbol": "CFTR",
        "hgnc": "HGNC:1884",
        "name": "CF transmembrane conductance regulator",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cftr"
      },
      {
        "slug": "dact1",
        "symbol": "DACT1",
        "hgnc": "HGNC:17748",
        "name": "dishevelled binding antagonist of beta catenin 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dact1"
      },
      {
        "slug": "hnf1b",
        "symbol": "HNF1B",
        "hgnc": "HGNC:11630",
        "name": "HNF1 homeobox B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hnf1b"
      },
      {
        "slug": "nf1",
        "symbol": "NF1",
        "hgnc": "HGNC:7765",
        "name": "neurofibromin 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nf1"
      },
      {
        "slug": "pacs1",
        "symbol": "PACS1",
        "hgnc": "HGNC:30032",
        "name": "phosphofurin acidic cluster sorting protein 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pacs1"
      },
      {
        "slug": "sall1",
        "symbol": "SALL1",
        "hgnc": "HGNC:10524",
        "name": "spalt like transcription factor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sall1"
      },
      {
        "slug": "glmn",
        "symbol": "GLMN",
        "hgnc": "HGNC:14373",
        "name": "glomulin, FKBP associated protein",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/glmn"
      },
      {
        "slug": "pah",
        "symbol": "PAH",
        "hgnc": "HGNC:8582",
        "name": "phenylalanine hydroxylase",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pah"
      },
      {
        "slug": "slc35a2",
        "symbol": "SLC35A2",
        "hgnc": "HGNC:11022",
        "name": "solute carrier family 35 member A2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc35a2"
      },
      {
        "slug": "fgfr2",
        "symbol": "FGFR2",
        "hgnc": "HGNC:3689",
        "name": "fibroblast growth factor receptor 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fgfr2"
      },
      {
        "slug": "flcn",
        "symbol": "FLCN",
        "hgnc": "HGNC:27310",
        "name": "folliculin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/flcn"
      },
      {
        "slug": "pigv",
        "symbol": "PIGV",
        "hgnc": "HGNC:26031",
        "name": "phosphatidylinositol glycan anchor biosynthesis class V",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pigv"
      },
      {
        "slug": "por",
        "symbol": "POR",
        "hgnc": "HGNC:9208",
        "name": "cytochrome p450 oxidoreductase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/por"
      }
    ]
  }
}