{
  "url": "https://dantelabs.com/it/genes/zfp57",
  "gene": {
    "slug": "zfp57",
    "symbol": "ZFP57",
    "name": "ZFP57 zinc finger protein",
    "hgnc": "HGNC:18791",
    "summary": null,
    "location": "6p22.1",
    "locusType": "gene with protein product",
    "aliases": [
      "ZNF698",
      "bA145L22",
      "bA145L22.2"
    ],
    "previousSymbols": [
      "C6orf40"
    ],
    "ensemblId": "ENSG00000204644",
    "entrezId": 346171,
    "omim": [
      "612192"
    ],
    "uniprot": [
      "Q9NU63"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "6",
      "start": 29672483,
      "end": 29681152,
      "strand": "-",
      "ensemblTranscript": "ENST00000376883.2",
      "refseqTranscript": "NM_001109809.5",
      "ensemblProtein": "ENSP00000366080.2",
      "refseqProtein": "NP_001103279.2",
      "exons": [
        {
          "start": 29672483,
          "end": 29673758
        },
        {
          "start": 29675386,
          "end": 29675487
        },
        {
          "start": 29675933,
          "end": 29676059
        },
        {
          "start": 29676881,
          "end": 29677366
        },
        {
          "start": 29681062,
          "end": 29681152
        }
      ],
      "cds": {
        "start": 29672500,
        "end": 29677003
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "6",
      "start": 29640169,
      "end": 29648887,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 29176818,
      "end": 30176817,
      "genes": [
        {
          "symbol": "OR14J1",
          "ensemblId": "ENSG00000204695",
          "biotype": "protein_coding",
          "start": 29301701,
          "end": 29313017,
          "strand": "+",
          "slug": "or14j1"
        },
        {
          "symbol": "OR5V1",
          "ensemblId": "ENSG00000243729",
          "biotype": "protein_coding",
          "start": 29353749,
          "end": 29431967,
          "strand": "-",
          "slug": "or5v1"
        },
        {
          "symbol": "OR12D3",
          "ensemblId": "ENSG00000112462",
          "biotype": "protein_coding",
          "start": 29373423,
          "end": 29375291,
          "strand": "-",
          "slug": "or12d3"
        },
        {
          "symbol": "OR12D2",
          "ensemblId": "ENSG00000280236",
          "biotype": "protein_coding",
          "start": 29395631,
          "end": 29398008,
          "strand": "+",
          "slug": "or12d2"
        },
        {
          "symbol": "OR12D1",
          "ensemblId": "ENSG00000251608",
          "biotype": "protein_coding",
          "start": 29414928,
          "end": 29418905,
          "strand": "+",
          "slug": "or12d1"
        },
        {
          "symbol": "OR11A1",
          "ensemblId": "ENSG00000204694",
          "biotype": "protein_coding",
          "start": 29425504,
          "end": 29457071,
          "strand": "-",
          "slug": "or11a1"
        },
        {
          "symbol": "OR10C1",
          "ensemblId": "ENSG00000206474",
          "biotype": "protein_coding",
          "start": 29439306,
          "end": 29440977,
          "strand": "+",
          "slug": "or10c1"
        },
        {
          "symbol": "OR2H1",
          "ensemblId": "ENSG00000204688",
          "biotype": "protein_coding",
          "start": 29457155,
          "end": 29464328,
          "strand": "+",
          "slug": "or2h1"
        },
        {
          "symbol": "MAS1L",
          "ensemblId": "ENSG00000204687",
          "biotype": "protein_coding",
          "start": 29486697,
          "end": 29487956,
          "strand": "-",
          "slug": "mas1l"
        },
        {
          "symbol": "OR2I1",
          "ensemblId": "ENSG00000237988",
          "biotype": "protein_coding",
          "start": 29550407,
          "end": 29557773,
          "strand": "+",
          "slug": "or2i1"
        },
        {
          "symbol": "GABBR1",
          "ensemblId": "ENSG00000204681",
          "biotype": "protein_coding",
          "start": 29552554,
          "end": 29633976,
          "strand": "-",
          "slug": "gabbr1"
        },
        {
          "symbol": "UBD",
          "ensemblId": "ENSG00000213886",
          "biotype": "protein_coding",
          "start": 29552554,
          "end": 29559738,
          "strand": "-",
          "slug": "ubd"
        },
        {
          "symbol": "OR2H2",
          "ensemblId": "ENSG00000204657",
          "biotype": "protein_coding",
          "start": 29585121,
          "end": 29590500,
          "strand": "+",
          "slug": "or2h2"
        },
        {
          "symbol": "MOG",
          "ensemblId": "ENSG00000204655",
          "biotype": "protein_coding",
          "start": 29656598,
          "end": 29674431,
          "strand": "+",
          "slug": "mog"
        },
        {
          "symbol": "HLA-F",
          "ensemblId": "ENSG00000204642",
          "biotype": "protein_coding",
          "start": 29722738,
          "end": 29740358,
          "strand": "+",
          "slug": "hla-f"
        },
        {
          "symbol": "HLA-G",
          "ensemblId": "ENSG00000204632",
          "biotype": "protein_coding",
          "start": 29826967,
          "end": 29831130,
          "strand": "+",
          "slug": "hla-g"
        },
        {
          "symbol": "HLA-A",
          "ensemblId": "ENSG00000206503",
          "biotype": "protein_coding",
          "start": 29941260,
          "end": 29949606,
          "strand": "+",
          "slug": "hla-a"
        },
        {
          "symbol": "POLR1H",
          "ensemblId": "ENSG00000066379",
          "biotype": "protein_coding",
          "start": 30058899,
          "end": 30064909,
          "strand": "+",
          "slug": "polr1h"
        },
        {
          "symbol": "PPP1R11",
          "ensemblId": "ENSG00000204619",
          "biotype": "protein_coding",
          "start": 30066709,
          "end": 30074025,
          "strand": "+",
          "slug": "ppp1r11"
        },
        {
          "symbol": "RNF39",
          "ensemblId": "ENSG00000204618",
          "biotype": "protein_coding",
          "start": 30070266,
          "end": 30075849,
          "strand": "-",
          "slug": "rnf39"
        },
        {
          "symbol": "TRIM31",
          "ensemblId": "ENSG00000204616",
          "biotype": "protein_coding",
          "start": 30102886,
          "end": 30113126,
          "strand": "-",
          "slug": "trim31"
        },
        {
          "symbol": "TRIM40",
          "ensemblId": "ENSG00000204614",
          "biotype": "protein_coding",
          "start": 30136028,
          "end": 30151592,
          "strand": "+",
          "slug": "trim40"
        },
        {
          "symbol": "TRIM10",
          "ensemblId": "ENSG00000204613",
          "biotype": "protein_coding",
          "start": 30151943,
          "end": 30161288,
          "strand": "-",
          "slug": "trim10"
        },
        {
          "symbol": "TRIM15",
          "ensemblId": "ENSG00000204610",
          "biotype": "protein_coding",
          "start": 30163194,
          "end": 30173160,
          "strand": "+",
          "slug": "trim15"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "diabetes-mellitus",
        "name": "Diabete mellito",
        "diseases": [
          {
            "mondoId": "MONDO:0005015",
            "name": "Diabete mellito",
            "genes": 31,
            "inheritance": null,
            "description": "Un disturbo metabolico caratterizzato da livelli anormalmente elevati di glucosio nel sangue dovuti a una ridotta produzione di insulina o a insulino-resistenza/desensibilizzazione.",
            "management": "Teplizumab (Tzield) per il T1D presintomatico di stadio 2 (approvato dalla FDA nel 2022); terapia insulinica sostitutiva all'esordio clinico del T1D; screening degli autoanticorpi TrialNet per i familiari ad alto rischio; sistemi di somministrazione dell'insulina a circuito chiuso",
            "evidence": {
              "gencc": [
                "G2P",
                "Genomics England PanelApp",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": true,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/it/conditions/diabetes-mellitus"
      },
      {
        "slug": "neonatal-diabetes-mellitus",
        "name": "Diabete mellito neonatale",
        "diseases": [
          {
            "mondoId": "MONDO:0016391",
            "name": "Diabete mellito neonatale",
            "genes": 20,
            "inheritance": null,
            "description": "Diabete diagnosticato nei primi mesi di vita, permanente o transitorio, causato da difetti a singolo gene nella produzione o nella secrezione di insulina.",
            "management": "La maggior parte delle persone con diabete neonatale dovuto a KCNJ11 o ABCC8 può passare dalle iniezioni di insulina alle compresse di sulfonilurea, spesso con un migliore controllo della glicemia.",
            "evidence": {
              "gencc": [
                "G2P",
                "Genomics England PanelApp",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": true,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/it/conditions/neonatal-diabetes-mellitus"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abnormality-of-limbs",
        "name": "Abnormality of limbs",
        "systems": [],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormality-of-limbs"
      },
      {
        "slug": "abnormal-heart-morphology",
        "name": "Abnormality of the heart",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormal-heart-morphology"
      },
      {
        "slug": "abnormality-of-the-kidney",
        "name": "Abnormality of the kidney",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormality-of-the-kidney"
      },
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "systems": [],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      },
      {
        "slug": "macroglossia",
        "name": "Abnormally large tongue",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/macroglossia"
      },
      {
        "slug": "autoimmune-antibody-positivity",
        "name": "Autoimmune antibody positivity",
        "systems": [
          "abnormality-of-the-immune-system"
        ],
        "url": "https://dantelabs.com/traits/autoimmune-antibody-positivity"
      },
      {
        "slug": "dehydration",
        "name": "Dehydration",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/dehydration"
      },
      {
        "slug": "diabetic-ketoacidosis",
        "name": "Diabetic ketoacidosis",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/diabetic-ketoacidosis"
      },
      {
        "slug": "seizure",
        "name": "Epilepsy",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/seizure"
      },
      {
        "slug": "failure-to-thrive",
        "name": "Faltering weight",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/failure-to-thrive"
      },
      {
        "slug": "hearing-impairment",
        "name": "Hearing impairment",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hearing-impairment"
      },
      {
        "slug": "hyperglycemia",
        "name": "High blood sugar",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/hyperglycemia"
      },
      {
        "slug": "hypoinsulinemia",
        "name": "Hypoinsulinemia",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/hypoinsulinemia"
      },
      {
        "slug": "hypotonia",
        "name": "Low muscle tone",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hypotonia"
      },
      {
        "slug": "maturity-onset-diabetes-of-the-young",
        "name": "Maturity-onset diabetes of the young",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/maturity-onset-diabetes-of-the-young"
      },
      {
        "slug": "neurodevelopmental-delay",
        "name": "Neurodevelopmental delay",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/neurodevelopmental-delay"
      },
      {
        "slug": "intrauterine-growth-retardation",
        "name": "Prenatal growth deficiency",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/intrauterine-growth-retardation"
      },
      {
        "slug": "severe-failure-to-thrive",
        "name": "Severe faltering weight",
        "systems": [
          "growth-abnormality"
        ],
        "url": "https://dantelabs.com/traits/severe-failure-to-thrive"
      },
      {
        "slug": "small-for-gestational-age",
        "name": "Small for gestational age",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/small-for-gestational-age"
      },
      {
        "slug": "transient-neonatal-diabetes-mellitus",
        "name": "Transient neonatal diabetes mellitus",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/transient-neonatal-diabetes-mellitus"
      },
      {
        "slug": "umbilical-hernia",
        "name": "Umbilical hernia",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/umbilical-hernia"
      },
      {
        "slug": "hypothyroidism",
        "name": "Underactive thyroid",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hypothyroidism"
      },
      {
        "slug": "abnormality-of-the-urinary-system",
        "name": "Urinary tract abnormalities",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormality-of-the-urinary-system"
      }
    ],
    "related": [
      {
        "slug": "abcc8",
        "symbol": "ABCC8",
        "name": "ATP binding cassette subfamily C member 8",
        "shared": 2,
        "url": "https://dantelabs.com/it/genes/abcc8"
      },
      {
        "slug": "bscl2",
        "symbol": "BSCL2",
        "name": "BSCL2 lipid droplet biogenesis associated, seipin",
        "shared": 2,
        "url": "https://dantelabs.com/it/genes/bscl2"
      },
      {
        "slug": "eif2b1",
        "symbol": "EIF2B1",
        "name": "eukaryotic translation initiation factor 2B subunit alpha",
        "shared": 2,
        "url": "https://dantelabs.com/it/genes/eif2b1"
      },
      {
        "slug": "gata4",
        "symbol": "GATA4",
        "name": "GATA binding protein 4",
        "shared": 2,
        "url": "https://dantelabs.com/it/genes/gata4"
      },
      {
        "slug": "gata6",
        "symbol": "GATA6",
        "name": "GATA binding protein 6",
        "shared": 2,
        "url": "https://dantelabs.com/it/genes/gata6"
      },
      {
        "slug": "gck",
        "symbol": "GCK",
        "name": "glucokinase",
        "shared": 2,
        "url": "https://dantelabs.com/it/genes/gck"
      },
      {
        "slug": "glis3",
        "symbol": "GLIS3",
        "name": "GLIS family zinc finger 3",
        "shared": 2,
        "url": "https://dantelabs.com/it/genes/glis3"
      },
      {
        "slug": "hnf1b",
        "symbol": "HNF1B",
        "name": "HNF1 homeobox B",
        "shared": 2,
        "url": "https://dantelabs.com/it/genes/hnf1b"
      },
      {
        "slug": "il2ra",
        "symbol": "IL2RA",
        "name": "interleukin 2 receptor subunit alpha",
        "shared": 2,
        "url": "https://dantelabs.com/it/genes/il2ra"
      },
      {
        "slug": "ins",
        "symbol": "INS",
        "name": "insulin",
        "shared": 2,
        "url": "https://dantelabs.com/it/genes/ins"
      },
      {
        "slug": "kcnj11",
        "symbol": "KCNJ11",
        "name": "potassium inwardly rectifying channel subfamily J member 11",
        "shared": 2,
        "url": "https://dantelabs.com/it/genes/kcnj11"
      },
      {
        "slug": "mnx1",
        "symbol": "MNX1",
        "name": "motor neuron and pancreas homeobox 1",
        "shared": 2,
        "url": "https://dantelabs.com/it/genes/mnx1"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}