{
  "url": "https://dantelabs.com/it/genes/kl",
  "gene": {
    "slug": "kl",
    "symbol": "KL",
    "name": "klotho",
    "hgnc": "HGNC:6344",
    "summary": null,
    "location": "13q13.1",
    "locusType": "gene with protein product",
    "aliases": [
      "KLA"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000133116",
    "entrezId": 9365,
    "omim": [
      "604824"
    ],
    "uniprot": [
      "Q9UEF7"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "13",
      "start": 33016423,
      "end": 33066143,
      "strand": "+",
      "ensemblTranscript": "ENST00000380099.4",
      "refseqTranscript": "NM_004795.4",
      "ensemblProtein": "ENSP00000369442.3",
      "refseqProtein": "NP_004786.2",
      "exons": [
        {
          "start": 33016423,
          "end": 33017259
        },
        {
          "start": 33053767,
          "end": 33054277
        },
        {
          "start": 33055047,
          "end": 33055315
        },
        {
          "start": 33060679,
          "end": 33061780
        },
        {
          "start": 33063849,
          "end": 33066143
        }
      ],
      "cds": {
        "start": 33016441,
        "end": 33064186
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "13",
      "start": 33590207,
      "end": 33640282,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
      "start": 32541283,
      "end": 33541282,
      "genes": [
        {
          "symbol": "PDS5B",
          "ensemblId": "ENSG00000083642",
          "biotype": "protein_coding",
          "start": 32586315,
          "end": 32778320,
          "strand": "+",
          "slug": "pds5b"
        },
        {
          "symbol": "STARD13",
          "ensemblId": "ENSG00000133121",
          "biotype": "protein_coding",
          "start": 33103137,
          "end": 33350685,
          "strand": "-",
          "slug": "stard13"
        }
      ],
      "truncated": false
    },
    "reports": [],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "cerebral-calcification",
        "name": "Abnormal deposits of calcium in the brain",
        "systems": [
          "abnormality-of-the-musculoskeletal-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/cerebral-calcification"
      },
      {
        "slug": "achilles-tendon-calcification",
        "name": "Achilles tendon calcification",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/achilles-tendon-calcification"
      },
      {
        "slug": "calvarial-osteosclerosis",
        "name": "Calvarial osteosclerosis",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/calvarial-osteosclerosis"
      },
      {
        "slug": "elevated-circulating-calcitriol-concentration",
        "name": "Elevated circulating calcitriol concentration",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/elevated-circulating-calcitriol-concentration"
      },
      {
        "slug": "elevated-circulating-parathyroid-hormone-level",
        "name": "Elevated circulating parathyroid hormone level",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/elevated-circulating-parathyroid-hormone-level"
      },
      {
        "slug": "parathyroid-hyperplasia",
        "name": "Enlarged parathyroid glands",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/parathyroid-hyperplasia"
      },
      {
        "slug": "fatigue",
        "name": "Fatigue",
        "systems": [
          "constitutional-symptom"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/fatigue"
      },
      {
        "slug": "headache",
        "name": "Headache",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/headache"
      },
      {
        "slug": "hypercalcemia",
        "name": "High blood calcium levels",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hypercalcemia"
      },
      {
        "slug": "hyperphosphatemia",
        "name": "High blood phosphate levels",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hyperphosphatemia"
      },
      {
        "slug": "metacarpal-periosteal-thickening",
        "name": "Metacarpal periosteal thickening",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/metacarpal-periosteal-thickening"
      },
      {
        "slug": "osteopenia",
        "name": "Osteopenia",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/osteopenia"
      }
    ],
    "related": [],
    "sources": null,
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}