{
  "url": "https://dantelabs.com/it/genes/icoslg",
  "gene": {
    "slug": "icoslg",
    "symbol": "ICOSLG",
    "name": "inducible T cell costimulator ligand",
    "hgnc": "HGNC:17087",
    "summary": null,
    "location": "21q22.3",
    "locusType": "gene with protein product",
    "aliases": [
      "KIAA0653",
      "GL50",
      "B7-H2",
      "B7RP-1",
      "B7H2",
      "B7RP1",
      "ICOS-L",
      "CD275",
      "B7h"
    ],
    "previousSymbols": [
      "ICOSL"
    ],
    "ensemblId": "ENSG00000160223",
    "entrezId": 23308,
    "omim": [
      "605717"
    ],
    "uniprot": [
      "O75144"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "21",
      "start": 44222991,
      "end": 44240943,
      "strand": "-",
      "ensemblTranscript": "ENST00000407780.8",
      "refseqTranscript": "NM_015259.6",
      "ensemblProtein": "ENSP00000384432.3",
      "refseqProtein": "NP_056074.1",
      "exons": [
        {
          "start": 44222991,
          "end": 44229044
        },
        {
          "start": 44230054,
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        },
        {
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        }
      ],
      "cds": {
        "start": 44229034,
        "end": 44240817
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "21",
      "start": 45642874,
      "end": 45660849,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
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      "end": 44731966,
      "genes": [
        {
          "symbol": "PDXK",
          "ensemblId": "ENSG00000160209",
          "biotype": "protein_coding",
          "start": 43719061,
          "end": 43762307,
          "strand": "+",
          "slug": "pdxk"
        },
        {
          "symbol": "CSTB",
          "ensemblId": "ENSG00000160213",
          "biotype": "protein_coding",
          "start": 43772511,
          "end": 43776608,
          "strand": "-",
          "slug": "cstb"
        },
        {
          "symbol": "RRP1",
          "ensemblId": "ENSG00000160214",
          "biotype": "protein_coding",
          "start": 43789513,
          "end": 43821500,
          "strand": "+",
          "slug": "rrp1"
        },
        {
          "symbol": "AGPAT3",
          "ensemblId": "ENSG00000160216",
          "biotype": "protein_coding",
          "start": 43865081,
          "end": 43987592,
          "strand": "+",
          "slug": "agpat3"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000288593",
          "biotype": "protein_coding",
          "start": 43939919,
          "end": 43959673,
          "strand": "+"
        },
        {
          "symbol": "TRAPPC10",
          "ensemblId": "ENSG00000160218",
          "biotype": "protein_coding",
          "start": 44012280,
          "end": 44106553,
          "strand": "+",
          "slug": "trappc10"
        },
        {
          "symbol": "PWP2",
          "ensemblId": "ENSG00000241945",
          "biotype": "protein_coding",
          "start": 44107306,
          "end": 44131181,
          "strand": "+",
          "slug": "pwp2"
        },
        {
          "symbol": "GATD3",
          "ensemblId": "ENSG00000160221",
          "biotype": "protein_coding",
          "start": 44133610,
          "end": 44210114,
          "strand": "+",
          "slug": "gatd3"
        },
        {
          "symbol": "DNMT3L",
          "ensemblId": "ENSG00000142182",
          "biotype": "protein_coding",
          "start": 44246339,
          "end": 44262216,
          "strand": "-",
          "slug": "dnmt3l"
        },
        {
          "symbol": "AIRE",
          "ensemblId": "ENSG00000160224",
          "biotype": "protein_coding",
          "start": 44285838,
          "end": 44298648,
          "strand": "+",
          "slug": "aire"
        },
        {
          "symbol": "PFKL",
          "ensemblId": "ENSG00000141959",
          "biotype": "protein_coding",
          "start": 44300017,
          "end": 44327377,
          "strand": "+",
          "slug": "pfkl"
        },
        {
          "symbol": "CFAP410",
          "ensemblId": "ENSG00000160226",
          "biotype": "protein_coding",
          "start": 44328943,
          "end": 44339427,
          "strand": "-",
          "slug": "cfap410"
        },
        {
          "symbol": "TRPM2",
          "ensemblId": "ENSG00000142185",
          "biotype": "protein_coding",
          "start": 44350072,
          "end": 44445246,
          "strand": "+",
          "slug": "trpm2"
        },
        {
          "symbol": "LRRC3",
          "ensemblId": "ENSG00000160233",
          "biotype": "protein_coding",
          "start": 44455472,
          "end": 44463452,
          "strand": "+",
          "slug": "lrrc3"
        },
        {
          "symbol": "TSPEAR",
          "ensemblId": "ENSG00000175894",
          "biotype": "protein_coding",
          "start": 44497893,
          "end": 44712286,
          "strand": "-",
          "slug": "tspear"
        },
        {
          "symbol": "KRTAP10-1",
          "ensemblId": "ENSG00000215455",
          "biotype": "protein_coding",
          "start": 44538981,
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          "strand": "-",
          "slug": "krtap10-1"
        },
        {
          "symbol": "KRTAP10-2",
          "ensemblId": "ENSG00000205445",
          "biotype": "protein_coding",
          "start": 44550357,
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          "strand": "-",
          "slug": "krtap10-2"
        },
        {
          "symbol": "KRTAP10-3",
          "ensemblId": "ENSG00000212935",
          "biotype": "protein_coding",
          "start": 44557790,
          "end": 44558795,
          "strand": "-",
          "slug": "krtap10-3"
        },
        {
          "symbol": "KRTAP10-4",
          "ensemblId": "ENSG00000215454",
          "biotype": "protein_coding",
          "start": 44573729,
          "end": 44575371,
          "strand": "+",
          "slug": "krtap10-4"
        },
        {
          "symbol": "KRTAP10-5",
          "ensemblId": "ENSG00000241123",
          "biotype": "protein_coding",
          "start": 44579455,
          "end": 44580604,
          "strand": "-",
          "slug": "krtap10-5"
        },
        {
          "symbol": "KRTAP10-6",
          "ensemblId": "ENSG00000188155",
          "biotype": "protein_coding",
          "start": 44591268,
          "end": 44592505,
          "strand": "-",
          "slug": "krtap10-6"
        },
        {
          "symbol": "KRTAP10-7",
          "ensemblId": "ENSG00000272804",
          "biotype": "protein_coding",
          "start": 44600597,
          "end": 44602174,
          "strand": "+",
          "slug": "krtap10-7"
        },
        {
          "symbol": "KRTAP10-8",
          "ensemblId": "ENSG00000187766",
          "biotype": "protein_coding",
          "start": 44612079,
          "end": 44612954,
          "strand": "+",
          "slug": "krtap10-8"
        },
        {
          "symbol": "KRTAP10-9",
          "ensemblId": "ENSG00000221837",
          "biotype": "protein_coding",
          "start": 44627093,
          "end": 44628378,
          "strand": "+",
          "slug": "krtap10-9"
        },
        {
          "symbol": "KRTAP10-10",
          "ensemblId": "ENSG00000221859",
          "biotype": "protein_coding",
          "start": 44637356,
          "end": 44638455,
          "strand": "+",
          "slug": "krtap10-10"
        },
        {
          "symbol": "KRTAP10-11",
          "ensemblId": "ENSG00000243489",
          "biotype": "protein_coding",
          "start": 44646414,
          "end": 44647650,
          "strand": "+",
          "slug": "krtap10-11"
        },
        {
          "symbol": "KRTAP12-4",
          "ensemblId": "ENSG00000212933",
          "biotype": "protein_coding",
          "start": 44654213,
          "end": 44654659,
          "strand": "-",
          "slug": "krtap12-4"
        },
        {
          "symbol": "KRTAP12-3",
          "ensemblId": "ENSG00000205439",
          "biotype": "protein_coding",
          "start": 44657932,
          "end": 44658341,
          "strand": "+",
          "slug": "krtap12-3"
        },
        {
          "symbol": "KRTAP12-2",
          "ensemblId": "ENSG00000221864",
          "biotype": "protein_coding",
          "start": 44666189,
          "end": 44666927,
          "strand": "-",
          "slug": "krtap12-2"
        },
        {
          "symbol": "KRTAP12-1",
          "ensemblId": "ENSG00000187175",
          "biotype": "protein_coding",
          "start": 44681576,
          "end": 44682163,
          "strand": "-",
          "slug": "krtap12-1"
        },
        {
          "symbol": "KRTAP10-12",
          "ensemblId": "ENSG00000189169",
          "biotype": "protein_coding",
          "start": 44697172,
          "end": 44698044,
          "strand": "+",
          "slug": "krtap10-12"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "immunodeficiency-disease",
        "name": "Altri errori innati dell'immunità",
        "diseases": [
          {
            "mondoId": "MONDO:0021094",
            "name": "Malattia da immunodeficienza",
            "genes": 170,
            "inheritance": null,
            "description": "Malattia caratterizzata da un deficit o da un'anomalia nei meccanismi dell'immunità, sia essa cellulare o umorale.",
            "management": "HSCT per SCID e PID gravi; terapia sostitutiva con immunoglobuline (IVIG/SCIG) per i deficit anticorpali; leniolisib (Joenja, FDA 2023) per APDS; terapia genica per ADA-SCID; abatacept per il deficit di CTLA4/LRBA; profilassi antibiotica; G-CSF per CGD",
            "evidence": {
              "gencc": [],
              "clingen": "Moderate",
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": false,
            "broad": true
          }
        ],
        "url": "https://dantelabs.com/it/conditions/immunodeficiency-disease"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "combined-immunodeficiency",
        "name": "Combined immunodeficiency",
        "systems": [
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/combined-immunodeficiency"
      },
      {
        "slug": "decreased-total-lymphocyte-count",
        "name": "Decreased blood lymphocyte number",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/decreased-total-lymphocyte-count"
      },
      {
        "slug": "decreased-circulating-immunoglobulin-concentration",
        "name": "Decreased circulating antibody level",
        "systems": [
          "abnormal-cellular-phenotype",
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/decreased-circulating-immunoglobulin-concentration"
      },
      {
        "slug": "decreased-class-switched-memory-b-cell-proportion",
        "name": "Decreased class-switched memory B cell proportion",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/decreased-class-switched-memory-b-cell-proportion"
      },
      {
        "slug": "genital-warts",
        "name": "Genital warts",
        "systems": [
          "abnormality-of-the-integument",
          "neoplasm"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/genital-warts"
      },
      {
        "slug": "angular-cheilitis",
        "name": "Inflammation of corners of the mouth",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/angular-cheilitis"
      },
      {
        "slug": "decreased-total-neutrophil-count",
        "name": "Low blood neutrophil count",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/decreased-total-neutrophil-count"
      },
      {
        "slug": "pneumonia",
        "name": "Pneumonia",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/pneumonia"
      },
      {
        "slug": "recurrent-bronchitis",
        "name": "Recurrent bronchitis",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/recurrent-bronchitis"
      },
      {
        "slug": "recurrent-otitis-media",
        "name": "Recurrent middle ear infection",
        "systems": [
          "abnormality-of-the-ear",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/recurrent-otitis-media"
      },
      {
        "slug": "recurrent-oral-herpes",
        "name": "Recurrent oral herpes",
        "systems": [
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/recurrent-oral-herpes"
      },
      {
        "slug": "recurrent-sinusitis",
        "name": "Recurrent sinus disease",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-immune-system",
          "abnormality-of-the-musculoskeletal-system",
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/recurrent-sinusitis"
      }
    ],
    "related": [
      {
        "slug": "ada",
        "symbol": "ADA",
        "name": "adenosine deaminase",
        "shared": 1,
        "url": "https://dantelabs.com/it/genes/ada"
      },
      {
        "slug": "aicda",
        "symbol": "AICDA",
        "name": "activation induced cytidine deaminase",
        "shared": 1,
        "url": "https://dantelabs.com/it/genes/aicda"
      },
      {
        "slug": "ak2",
        "symbol": "AK2",
        "name": "adenylate kinase 2",
        "shared": 1,
        "url": "https://dantelabs.com/it/genes/ak2"
      },
      {
        "slug": "arpc1b",
        "symbol": "ARPC1B",
        "name": "actin related protein 2/3 complex subunit 1B",
        "shared": 1,
        "url": "https://dantelabs.com/it/genes/arpc1b"
      },
      {
        "slug": "arpc5",
        "symbol": "ARPC5",
        "name": "actin related protein 2/3 complex subunit 5",
        "shared": 1,
        "url": "https://dantelabs.com/it/genes/arpc5"
      },
      {
        "slug": "atm",
        "symbol": "ATM",
        "name": "ATM serine/threonine kinase",
        "shared": 1,
        "url": "https://dantelabs.com/it/genes/atm"
      },
      {
        "slug": "atp6ap1",
        "symbol": "ATP6AP1",
        "name": "ATPase H+ transporting accessory protein 1",
        "shared": 1,
        "url": "https://dantelabs.com/it/genes/atp6ap1"
      },
      {
        "slug": "b2m",
        "symbol": "B2M",
        "name": "beta-2-microglobulin",
        "shared": 1,
        "url": "https://dantelabs.com/it/genes/b2m"
      },
      {
        "slug": "bach2",
        "symbol": "BACH2",
        "name": "BACH transcriptional regulator 2",
        "shared": 1,
        "url": "https://dantelabs.com/it/genes/bach2"
      },
      {
        "slug": "bcl10",
        "symbol": "BCL10",
        "name": "BCL10 immune signaling adaptor",
        "shared": 1,
        "url": "https://dantelabs.com/it/genes/bcl10"
      },
      {
        "slug": "bcl11b",
        "symbol": "BCL11B",
        "name": "BCL11 transcription factor B",
        "shared": 1,
        "url": "https://dantelabs.com/it/genes/bcl11b"
      },
      {
        "slug": "blnk",
        "symbol": "BLNK",
        "name": "B cell linker",
        "shared": 1,
        "url": "https://dantelabs.com/it/genes/blnk"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}