{
  "url": "https://dantelabs.com/it/genes/hic1",
  "gene": {
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    "symbol": "HIC1",
    "name": "HIC ZBTB transcriptional repressor 1",
    "hgnc": "HGNC:4909",
    "summary": null,
    "location": "17p13.3",
    "locusType": "gene with protein product",
    "aliases": [
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      "ZNF901"
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    "previousSymbols": [],
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    "entrezId": 3090,
    "omim": [
      "603825"
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    "uniprot": [
      "Q14526"
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      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "17",
      "start": 2055103,
      "end": 2063241,
      "strand": "+",
      "ensemblTranscript": "ENST00000619757.5",
      "refseqTranscript": "NM_006497.4",
      "ensemblProtein": "ENSP00000477858.1",
      "refseqProtein": "NP_006488.2",
      "exons": [
        {
          "start": 2055103,
          "end": 2055238
        },
        {
          "start": 2056671,
          "end": 2063241
        }
      ],
      "cds": {
        "start": 2056691,
        "end": 2058835
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    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "17",
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      "end": 1962981,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
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      "genes": [
        {
          "symbol": "PITPNA",
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          "biotype": "protein_coding",
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          "end": 1562861,
          "strand": "-",
          "slug": "pitpna"
        },
        {
          "symbol": "SLC43A2",
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          "biotype": "protein_coding",
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        },
        {
          "symbol": "SCARF1",
          "ensemblId": "ENSG00000074660",
          "biotype": "protein_coding",
          "start": 1633848,
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        {
          "symbol": "RILP",
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          "slug": "rilp"
        },
        {
          "symbol": "PRPF8",
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          "biotype": "protein_coding",
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        {
          "symbol": "TLCD2",
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        {
          "symbol": "WDR81",
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        {
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        {
          "symbol": "SERPINF1",
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        {
          "symbol": "SMYD4",
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        {
          "symbol": "RPA1",
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          "biotype": "protein_coding",
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        },
        {
          "symbol": "RTN4RL1",
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        {
          "symbol": "DPH1",
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        {
          "symbol": "OVCA2",
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        },
        {
          "symbol": "SMG6",
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          "strand": "-",
          "slug": "smg6"
        },
        {
          "symbol": "SRR",
          "ensemblId": "ENSG00000167720",
          "biotype": "protein_coding",
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          "strand": "+",
          "slug": "srr"
        },
        {
          "symbol": "TSR1",
          "ensemblId": "ENSG00000167721",
          "biotype": "protein_coding",
          "start": 2322376,
          "end": 2337965,
          "strand": "-",
          "slug": "tsr1"
        },
        {
          "symbol": "SGSM2",
          "ensemblId": "ENSG00000141258",
          "biotype": "protein_coding",
          "start": 2337488,
          "end": 2381058,
          "strand": "+",
          "slug": "sgsm2"
        },
        {
          "symbol": "MNT",
          "ensemblId": "ENSG00000070444",
          "biotype": "protein_coding",
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          "end": 2401142,
          "strand": "-",
          "slug": "mnt"
        },
        {
          "symbol": "METTL16",
          "ensemblId": "ENSG00000127804",
          "biotype": "protein_coding",
          "start": 2405562,
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          "strand": "-",
          "slug": "mettl16"
        }
      ],
      "truncated": false
    },
    "reports": [],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abnormality-of-the-cardiovascular-system",
        "name": "Abnormality of the cardiovascular system",
        "systems": [],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormality-of-the-cardiovascular-system"
      },
      {
        "slug": "abnormal-upper-lip-morphology",
        "name": "Abnormality of upper lip",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormal-upper-lip-morphology"
      },
      {
        "slug": "ataxia",
        "name": "Ataxia",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/ataxia"
      },
      {
        "slug": "clinodactyly-of-the-5th-finger",
        "name": "Curvature of little finger",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/clinodactyly-of-the-5th-finger"
      },
      {
        "slug": "cerebral-cortical-atrophy",
        "name": "Decrease in size of the outer layer of the brain due to loss of brain cells",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/cerebral-cortical-atrophy"
      },
      {
        "slug": "eeg-abnormality",
        "name": "EEG abnormality",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/eeg-abnormality"
      },
      {
        "slug": "seizure",
        "name": "Epilepsy",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/seizure"
      },
      {
        "slug": "epicanthus",
        "name": "Eye folds",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/epicanthus"
      },
      {
        "slug": "lissencephaly",
        "name": "Fewer or absent grooves in brain",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/lissencephaly"
      },
      {
        "slug": "growth-delay",
        "name": "Growth delay",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/growth-delay"
      },
      {
        "slug": "high-forehead",
        "name": "High forehead",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/high-forehead"
      },
      {
        "slug": "polyhydramnios",
        "name": "High levels of amniotic fluid",
        "systems": [
          "abnormality-of-prenatal-development-or-birth"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/polyhydramnios"
      },
      {
        "slug": "nephropathy",
        "name": "Kidney damage",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/nephropathy"
      },
      {
        "slug": "anteverted-nares",
        "name": "Nasal tip, upturned",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/anteverted-nares"
      },
      {
        "slug": "omphalocele",
        "name": "Omphalocele",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/omphalocele"
      },
      {
        "slug": "short-nose",
        "name": "Short nose",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/short-nose"
      },
      {
        "slug": "sacral-dimple",
        "name": "Spinal dimple",
        "systems": [
          "abnormality-of-the-integument",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/sacral-dimple"
      },
      {
        "slug": "hypoplasia-of-the-corpus-callosum",
        "name": "Underdevelopment of part of brain called corpus callosum",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hypoplasia-of-the-corpus-callosum"
      }
    ],
    "related": [],
    "sources": null,
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}