{
  "url": "https://dantelabs.com/traits/spotty-hypopigmentation",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "spotty-hypopigmentation",
    "id": "HP:0005590",
    "name": "Patchy hypopigmentation",
    "label": "Spotty hypopigmentation",
    "synonyms": [
      "Spotty decreased pigmentation",
      "Patchy depigmentation"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-integument",
        "name": "Abnormality of the integument",
        "url": "https://dantelabs.com/traits/abnormality-of-the-integument"
      }
    ],
    "broader": [
      {
        "slug": "hypopigmented-skin-patches",
        "name": "Patchy loss of skin color",
        "url": "https://dantelabs.com/traits/hypopigmented-skin-patches"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "blm",
        "symbol": "BLM",
        "hgnc": "HGNC:1058",
        "name": "BLM RecQ like helicase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/blm"
      },
      {
        "slug": "ebp",
        "symbol": "EBP",
        "hgnc": "HGNC:3133",
        "name": "EBP cholestenol delta-isomerase",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ebp"
      },
      {
        "slug": "abcb6",
        "symbol": "ABCB6",
        "hgnc": "HGNC:47",
        "name": "ATP binding cassette subfamily B member 6 (LAN blood group)",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abcb6"
      },
      {
        "slug": "abcc9",
        "symbol": "ABCC9",
        "hgnc": "HGNC:60",
        "name": "ATP binding cassette subfamily C member 9",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abcc9"
      },
      {
        "slug": "cript",
        "symbol": "CRIPT",
        "hgnc": "HGNC:14312",
        "name": "CXXC repeat containing interactor of PDZ3 domain",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cript"
      },
      {
        "slug": "krt14",
        "symbol": "KRT14",
        "hgnc": "HGNC:6416",
        "name": "keratin 14",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/krt14"
      },
      {
        "slug": "krt5",
        "symbol": "KRT5",
        "hgnc": "HGNC:6442",
        "name": "keratin 5",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/krt5"
      },
      {
        "slug": "ube2a",
        "symbol": "UBE2A",
        "hgnc": "HGNC:12472",
        "name": "ubiquitin conjugating enzyme E2 A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ube2a"
      },
      {
        "slug": "fermt1",
        "symbol": "FERMT1",
        "hgnc": "HGNC:15889",
        "name": "FERM domain containing kindlin 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fermt1"
      }
    ]
  }
}