{
  "url": "https://dantelabs.com/traits/skin-picking",
  "trait": {
    "bundleId": "2026.10.16-c6eea6bf",
    "release": "2026-09-01",
    "slug": "skin-picking",
    "id": "HP:0012166",
    "name": "Skin-picking",
    "definition": "Repetitive and compulsive picking of skin which results in tissue damage.",
    "synonyms": [
      "Compulsive skin picking",
      "Dermatillomania"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "self-injurious-behavior",
        "name": "Self-injurious behavior",
        "url": "https://dantelabs.com/traits/self-injurious-behavior"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "kdm2b",
        "symbol": "KDM2B",
        "hgnc": "HGNC:13610",
        "name": "lysine demethylase 2B",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kdm2b"
      },
      {
        "slug": "hdac4",
        "symbol": "HDAC4",
        "hgnc": "HGNC:14063",
        "name": "histone deacetylase 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hdac4"
      },
      {
        "slug": "magel2",
        "symbol": "MAGEL2",
        "hgnc": "HGNC:6814",
        "name": "MAGE family member L2",
        "frequency": "frequent",
        "diseases": 5,
        "url": "https://dantelabs.com/genes/magel2"
      },
      {
        "slug": "ndn",
        "symbol": "NDN",
        "hgnc": "HGNC:7675",
        "name": "necdin, MAGE family member",
        "frequency": "frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/ndn"
      },
      {
        "slug": "oca2",
        "symbol": "OCA2",
        "hgnc": "HGNC:8101",
        "name": "OCA2 melanosomal transmembrane protein",
        "frequency": "frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/oca2"
      },
      {
        "slug": "sim1",
        "symbol": "SIM1",
        "hgnc": "HGNC:10882",
        "name": "SIM bHLH transcription factor 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sim1"
      },
      {
        "slug": "snrpn",
        "symbol": "SNRPN",
        "hgnc": "HGNC:11164",
        "name": "small nuclear ribonucleoprotein polypeptide N",
        "frequency": "frequent",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/snrpn"
      },
      {
        "slug": "chd5",
        "symbol": "CHD5",
        "hgnc": "HGNC:16816",
        "name": "chromodomain helicase DNA binding protein 5",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chd5"
      },
      {
        "slug": "cntnap2",
        "symbol": "CNTNAP2",
        "hgnc": "HGNC:13830",
        "name": "contactin associated protein 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cntnap2"
      },
      {
        "slug": "usp7",
        "symbol": "USP7",
        "hgnc": "HGNC:12630",
        "name": "ubiquitin specific peptidase 7",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/usp7"
      },
      {
        "slug": "htr2a",
        "symbol": "HTR2A",
        "hgnc": "HGNC:5293",
        "name": "5-hydroxytryptamine receptor 2A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/htr2a"
      },
      {
        "slug": "kmt2e",
        "symbol": "KMT2E",
        "hgnc": "HGNC:18541",
        "name": "lysine methyltransferase 2E (inactive)",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kmt2e"
      },
      {
        "slug": "slc6a4",
        "symbol": "SLC6A4",
        "hgnc": "HGNC:11050",
        "name": "solute carrier family 6 member 4",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc6a4"
      }
    ]
  }
}