{
  "url": "https://dantelabs.com/traits/single-ventricle",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "single-ventricle",
    "id": "HP:0001750",
    "name": "Single ventricle",
    "definition": "The presence of only one working lower chamber in the heart, usually with a virtual absence of the ventricular septum and usually present in conjunction with double inlet left or right ventricle.",
    "synonyms": [
      "Common ventricle"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-cardiovascular-system",
        "name": "Abnormality of the cardiovascular system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-cardiovascular-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-cardiac-ventricle-morphology",
        "name": "Abnormal cardiac ventricle morphology",
        "url": "https://dantelabs.com/traits/abnormal-cardiac-ventricle-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "double-inlet-left-ventricle",
        "name": "Double inlet left ventricle",
        "genes": 3,
        "url": "https://dantelabs.com/traits/double-inlet-left-ventricle"
      },
      {
        "slug": "double-inlet-right-ventricle",
        "name": "Double inlet right ventricle",
        "genes": 1,
        "url": "https://dantelabs.com/traits/double-inlet-right-ventricle"
      },
      {
        "slug": "single-ventricle-of-indeterminate-morphology",
        "name": "Single ventricle of indeterminate morphology",
        "genes": 1,
        "url": "https://dantelabs.com/traits/single-ventricle-of-indeterminate-morphology"
      }
    ],
    "genes": [
      {
        "slug": "txndc15",
        "symbol": "TXNDC15",
        "hgnc": "HGNC:20652",
        "name": "thioredoxin domain containing 15",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/txndc15"
      },
      {
        "slug": "nodal",
        "symbol": "NODAL",
        "hgnc": "HGNC:7865",
        "name": "nodal growth differentiation factor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nodal"
      },
      {
        "slug": "stra6",
        "symbol": "STRA6",
        "hgnc": "HGNC:30650",
        "name": "signaling receptor and transporter of retinol STRA6",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stra6"
      },
      {
        "slug": "cirop",
        "symbol": "CIROP",
        "hgnc": "HGNC:53647",
        "name": "ciliated left-right organizer metallopeptidase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cirop"
      },
      {
        "slug": "zic3",
        "symbol": "ZIC3",
        "hgnc": "HGNC:12874",
        "name": "Zic family zinc finger 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zic3"
      },
      {
        "slug": "gdf1",
        "symbol": "GDF1",
        "hgnc": "HGNC:4214",
        "name": "growth differentiation factor 1",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gdf1"
      },
      {
        "slug": "nsdhl",
        "symbol": "NSDHL",
        "hgnc": "HGNC:13398",
        "name": "NAD(P) dependent 3-beta-hydroxysteroid dehydrogenase NSDHL",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nsdhl"
      },
      {
        "slug": "six3",
        "symbol": "SIX3",
        "hgnc": "HGNC:10889",
        "name": "SIX homeobox 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/six3"
      }
    ]
  }
}