{
  "url": "https://dantelabs.com/traits/prolonged-pr-interval",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "prolonged-pr-interval",
    "id": "HP:0012248",
    "name": "Prolonged PR interval",
    "definition": "Increased time for the PR interval (beginning of the P wave to the beginning of the QRS complex).",
    "synonyms": [
      "Electrocardiographic long PR interval",
      "Lengthened PR interval on EKG"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-cardiovascular-system",
        "name": "Abnormality of the cardiovascular system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-cardiovascular-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-pr-interval",
        "name": "Abnormal PR interval",
        "url": "https://dantelabs.com/traits/abnormal-pr-interval"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "dsg2",
        "symbol": "DSG2",
        "hgnc": "HGNC:3049",
        "name": "desmoglein 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dsg2"
      },
      {
        "slug": "gpd1l",
        "symbol": "GPD1L",
        "hgnc": "HGNC:28956",
        "name": "glycerol-3-phosphate dehydrogenase 1 like",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gpd1l"
      },
      {
        "slug": "kcna5",
        "symbol": "KCNA5",
        "hgnc": "HGNC:6224",
        "name": "potassium voltage-gated channel subfamily A member 5",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcna5"
      },
      {
        "slug": "scn2b",
        "symbol": "SCN2B",
        "hgnc": "HGNC:10589",
        "name": "sodium voltage-gated channel beta subunit 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scn2b"
      },
      {
        "slug": "scn5a",
        "symbol": "SCN5A",
        "hgnc": "HGNC:10593",
        "name": "sodium voltage-gated channel alpha subunit 5",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scn5a"
      },
      {
        "slug": "tll1",
        "symbol": "TLL1",
        "hgnc": "HGNC:11843",
        "name": "tolloid like 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tll1"
      },
      {
        "slug": "alpk3",
        "symbol": "ALPK3",
        "hgnc": "HGNC:17574",
        "name": "alpha kinase 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alpk3"
      },
      {
        "slug": "gnb5",
        "symbol": "GNB5",
        "hgnc": "HGNC:4401",
        "name": "G protein subunit beta 5",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gnb5"
      },
      {
        "slug": "clcnkb",
        "symbol": "CLCNKB",
        "hgnc": "HGNC:2027",
        "name": "chloride voltage-gated channel Kb",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/clcnkb"
      },
      {
        "slug": "slc12a3",
        "symbol": "SLC12A3",
        "hgnc": "HGNC:10912",
        "name": "solute carrier family 12 member 3",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc12a3"
      },
      {
        "slug": "nkx2-5",
        "symbol": "NKX2-5",
        "hgnc": "HGNC:2488",
        "name": "NK2 homeobox 5",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nkx2-5"
      }
    ]
  }
}