{
  "url": "https://dantelabs.com/traits/primitive-reflex",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "primitive-reflex",
    "id": "HP:0002476",
    "name": "Primitive reflex",
    "definition": "The primitive reflexes are a group of behavioral motor responses which are found in normal early development, are subsequently inhibited, but may be released from inhibition by cerebral, usually frontal, damage. They are thus part of a broader group of reflexes which reflect release phenomena, such as exaggerated stretch reflexes and extensor plantars. They do however involve more complex motor responses than such simple stretch reflexes, and are often a normal feature in the neonate or infant.",
    "synonyms": [
      "Archaic reflex",
      "Primitive reflexes"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-reflex",
        "name": "Abnormal reflex",
        "url": "https://dantelabs.com/traits/abnormal-reflex"
      }
    ],
    "narrower": [
      {
        "slug": "glabellar-reflex",
        "name": "Glabellar reflex",
        "genes": 4,
        "url": "https://dantelabs.com/traits/glabellar-reflex"
      },
      {
        "slug": "grasp-reflex",
        "name": "Grasp reflex",
        "genes": 3,
        "url": "https://dantelabs.com/traits/grasp-reflex"
      },
      {
        "slug": "palmomental-reflex",
        "name": "Palmomental reflex",
        "genes": 2,
        "url": "https://dantelabs.com/traits/palmomental-reflex"
      },
      {
        "slug": "persistent-asymmetrical-tonic-neck-reflex",
        "name": "Persistent asymmetrical tonic neck reflex",
        "genes": 1,
        "url": "https://dantelabs.com/traits/persistent-asymmetrical-tonic-neck-reflex"
      },
      {
        "slug": "suck-reflex",
        "name": "Suck reflex",
        "genes": 1,
        "url": "https://dantelabs.com/traits/suck-reflex"
      }
    ],
    "genes": [
      {
        "slug": "dctn1",
        "symbol": "DCTN1",
        "hgnc": "HGNC:2711",
        "name": "dynactin subunit 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dctn1"
      },
      {
        "slug": "gtpbp2",
        "symbol": "GTPBP2",
        "hgnc": "HGNC:4670",
        "name": "GTP binding protein 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gtpbp2"
      },
      {
        "slug": "ndufs8",
        "symbol": "NDUFS8",
        "hgnc": "HGNC:7715",
        "name": "NADH:ubiquinone oxidoreductase core subunit S8",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufs8"
      },
      {
        "slug": "st3gal3",
        "symbol": "ST3GAL3",
        "hgnc": "HGNC:10866",
        "name": "ST3 beta-galactoside alpha-2,3-sialyltransferase 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/st3gal3"
      },
      {
        "slug": "gm2a",
        "symbol": "GM2A",
        "hgnc": "HGNC:4367",
        "name": "ganglioside GM2 activator",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gm2a"
      },
      {
        "slug": "spg21",
        "symbol": "SPG21",
        "hgnc": "HGNC:20373",
        "name": "SPG21 abhydrolase domain containing, maspardin",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/spg21"
      },
      {
        "slug": "aldh18a1",
        "symbol": "ALDH18A1",
        "hgnc": "HGNC:9722",
        "name": "aldehyde dehydrogenase 18 family member A1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aldh18a1"
      },
      {
        "slug": "dnmt1",
        "symbol": "DNMT1",
        "hgnc": "HGNC:2976",
        "name": "DNA methyltransferase 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/dnmt1"
      },
      {
        "slug": "jph3",
        "symbol": "JPH3",
        "hgnc": "HGNC:14203",
        "name": "junctophilin 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/jph3"
      },
      {
        "slug": "rab18",
        "symbol": "RAB18",
        "hgnc": "HGNC:14244",
        "name": "RAB18, member RAS oncogene family",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rab18"
      },
      {
        "slug": "hadha",
        "symbol": "HADHA",
        "hgnc": "HGNC:4801",
        "name": "hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hadha"
      },
      {
        "slug": "hadhb",
        "symbol": "HADHB",
        "hgnc": "HGNC:4803",
        "name": "hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hadhb"
      },
      {
        "slug": "ctsf",
        "symbol": "CTSF",
        "hgnc": "HGNC:2531",
        "name": "cathepsin F",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctsf"
      },
      {
        "slug": "dpm2",
        "symbol": "DPM2",
        "hgnc": "HGNC:3006",
        "name": "dolichyl-phosphate mannosyltransferase subunit 2, regulatory",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dpm2"
      },
      {
        "slug": "mapt",
        "symbol": "MAPT",
        "hgnc": "HGNC:6893",
        "name": "microtubule associated protein tau",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mapt"
      },
      {
        "slug": "piezo2",
        "symbol": "PIEZO2",
        "hgnc": "HGNC:26270",
        "name": "piezo type mechanosensitive ion channel component 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/piezo2"
      },
      {
        "slug": "psen1",
        "symbol": "PSEN1",
        "hgnc": "HGNC:9508",
        "name": "presenilin 1",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/psen1"
      },
      {
        "slug": "trem2",
        "symbol": "TREM2",
        "hgnc": "HGNC:17761",
        "name": "triggering receptor expressed on myeloid cells 2",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/trem2"
      },
      {
        "slug": "tyrobp",
        "symbol": "TYROBP",
        "hgnc": "HGNC:12449",
        "name": "transmembrane immune signaling adaptor TYROBP",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tyrobp"
      }
    ]
  }
}