{
  "url": "https://dantelabs.com/traits/neurodevelopmental-abnormality",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "neurodevelopmental-abnormality",
    "id": "HP:0012759",
    "name": "Neurodevelopmental abnormality",
    "definition": "A deviation from normal of the neurological development of a child, which may include any or all of the aspects of the development of personal, social, gross or fine motor, and cognitive abilities.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-nervous-system-physiology",
        "name": "Abnormal nervous system physiology",
        "url": "https://dantelabs.com/traits/abnormal-nervous-system-physiology"
      }
    ],
    "narrower": [
      {
        "slug": "intellectual-disability",
        "name": "Intellectual disability",
        "genes": 1647,
        "url": "https://dantelabs.com/traits/intellectual-disability"
      },
      {
        "slug": "developmental-regression",
        "name": "Loss of developmental milestones",
        "genes": 447,
        "url": "https://dantelabs.com/traits/developmental-regression"
      },
      {
        "slug": "specific-learning-disability",
        "name": "Specific learning disability",
        "genes": 298,
        "url": "https://dantelabs.com/traits/specific-learning-disability"
      },
      {
        "slug": "neurodevelopmental-delay",
        "name": "Neurodevelopmental delay",
        "genes": 206,
        "url": "https://dantelabs.com/traits/neurodevelopmental-delay"
      },
      {
        "slug": "developmental-stagnation",
        "name": "Developmental stagnation",
        "genes": 19,
        "url": "https://dantelabs.com/traits/developmental-stagnation"
      }
    ],
    "genes": [
      {
        "slug": "app",
        "symbol": "APP",
        "hgnc": "HGNC:620",
        "name": "amyloid beta precursor protein",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/app"
      },
      {
        "slug": "cacna1g",
        "symbol": "CACNA1G",
        "hgnc": "HGNC:1394",
        "name": "calcium voltage-gated channel subunit alpha1 G",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cacna1g"
      },
      {
        "slug": "fgfr1",
        "symbol": "FGFR1",
        "hgnc": "HGNC:3688",
        "name": "fibroblast growth factor receptor 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fgfr1"
      },
      {
        "slug": "kras",
        "symbol": "KRAS",
        "hgnc": "HGNC:6407",
        "name": "KRas proto-oncogene, GTPase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kras"
      },
      {
        "slug": "prps1",
        "symbol": "PRPS1",
        "hgnc": "HGNC:9462",
        "name": "phosphoribosyl pyrophosphate synthetase 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prps1"
      },
      {
        "slug": "psen1",
        "symbol": "PSEN1",
        "hgnc": "HGNC:9508",
        "name": "presenilin 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/psen1"
      },
      {
        "slug": "psen2",
        "symbol": "PSEN2",
        "hgnc": "HGNC:9509",
        "name": "presenilin 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/psen2"
      },
      {
        "slug": "sorl1",
        "symbol": "SORL1",
        "hgnc": "HGNC:11185",
        "name": "sortilin related receptor 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sorl1"
      },
      {
        "slug": "tomm40",
        "symbol": "TOMM40",
        "hgnc": "HGNC:18001",
        "name": "translocase of outer mitochondrial membrane 40",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tomm40"
      },
      {
        "slug": "trem2",
        "symbol": "TREM2",
        "hgnc": "HGNC:17761",
        "name": "triggering receptor expressed on myeloid cells 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trem2"
      },
      {
        "slug": "abcc8",
        "symbol": "ABCC8",
        "hgnc": "HGNC:59",
        "name": "ATP binding cassette subfamily C member 8",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abcc8"
      },
      {
        "slug": "hnf1a",
        "symbol": "HNF1A",
        "hgnc": "HGNC:11621",
        "name": "HNF1 homeobox A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hnf1a"
      },
      {
        "slug": "kcnj11",
        "symbol": "KCNJ11",
        "hgnc": "HGNC:6257",
        "name": "potassium inwardly rectifying channel subfamily J member 11",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnj11"
      },
      {
        "slug": "rnu12",
        "symbol": "RNU12",
        "hgnc": "HGNC:19380",
        "name": "RNA, U12 small nuclear",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnu12"
      },
      {
        "slug": "ucp2",
        "symbol": "UCP2",
        "hgnc": "HGNC:12518",
        "name": "uncoupling protein 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ucp2"
      }
    ]
  }
}