{
  "url": "https://dantelabs.com/traits/myositis",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "myositis",
    "id": "HP:0100614",
    "name": "Muscle inflammation",
    "label": "Myositis",
    "definition": "A general term for inflammation of the muscles without respect to the underlying cause.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      },
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-skeletal-muscle-morphology",
        "name": "Abnormally shaped muscle",
        "url": "https://dantelabs.com/traits/abnormal-skeletal-muscle-morphology"
      },
      {
        "slug": "increased-inflammatory-response",
        "name": "Increased inflammatory response",
        "url": "https://dantelabs.com/traits/increased-inflammatory-response"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "psmb9",
        "symbol": "PSMB9",
        "hgnc": "HGNC:9546",
        "name": "proteasome 20S subunit beta 9",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/psmb9"
      },
      {
        "slug": "psmg2",
        "symbol": "PSMG2",
        "hgnc": "HGNC:24929",
        "name": "proteasome assembly chaperone 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/psmg2"
      },
      {
        "slug": "lama2",
        "symbol": "LAMA2",
        "hgnc": "HGNC:6482",
        "name": "laminin subunit alpha 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lama2"
      },
      {
        "slug": "arpc5",
        "symbol": "ARPC5",
        "hgnc": "HGNC:708",
        "name": "actin related protein 2/3 complex subunit 5",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arpc5"
      },
      {
        "slug": "lpin1",
        "symbol": "LPIN1",
        "hgnc": "HGNC:13345",
        "name": "lipin 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lpin1"
      },
      {
        "slug": "mefv",
        "symbol": "MEFV",
        "hgnc": "HGNC:6998",
        "name": "MEFV innate immunity regulator, pyrin",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mefv"
      },
      {
        "slug": "mt-co1",
        "symbol": "MT-CO1",
        "hgnc": "HGNC:7419",
        "name": "mitochondrially encoded cytochrome c oxidase I",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-co1"
      },
      {
        "slug": "mt-co3",
        "symbol": "MT-CO3",
        "hgnc": "HGNC:7422",
        "name": "mitochondrially encoded cytochrome c oxidase III",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-co3"
      },
      {
        "slug": "obscn",
        "symbol": "OBSCN",
        "hgnc": "HGNC:15719",
        "name": "obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/obscn"
      },
      {
        "slug": "ptpn6",
        "symbol": "PTPN6",
        "hgnc": "HGNC:9658",
        "name": "protein tyrosine phosphatase non-receptor type 6",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptpn6"
      },
      {
        "slug": "sting1",
        "symbol": "STING1",
        "hgnc": "HGNC:27962",
        "name": "stimulator of interferon response cGAMP interactor 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sting1"
      },
      {
        "slug": "c4a",
        "symbol": "C4A",
        "hgnc": "HGNC:1323",
        "name": "complement C4A (Chido/Rodgers blood group)",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/c4a"
      },
      {
        "slug": "ccr1",
        "symbol": "CCR1",
        "hgnc": "HGNC:1602",
        "name": "C-C motif chemokine receptor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccr1"
      },
      {
        "slug": "cd4",
        "symbol": "CD4",
        "hgnc": "HGNC:1678",
        "name": "CD4 molecule",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd4"
      },
      {
        "slug": "dtna",
        "symbol": "DTNA",
        "hgnc": "HGNC:3057",
        "name": "dystrobrevin alpha",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dtna"
      },
      {
        "slug": "erap1",
        "symbol": "ERAP1",
        "hgnc": "HGNC:18173",
        "name": "endoplasmic reticulum aminopeptidase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/erap1"
      },
      {
        "slug": "fas",
        "symbol": "FAS",
        "hgnc": "HGNC:11920",
        "name": "Fas cell surface death receptor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fas"
      },
      {
        "slug": "hla-b",
        "symbol": "HLA-B",
        "hgnc": "HGNC:4932",
        "name": "major histocompatibility complex, class I, B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hla-b"
      },
      {
        "slug": "ifngr1",
        "symbol": "IFNGR1",
        "hgnc": "HGNC:5439",
        "name": "interferon gamma receptor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ifngr1"
      },
      {
        "slug": "il10",
        "symbol": "IL10",
        "hgnc": "HGNC:5962",
        "name": "interleukin 10",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il10"
      },
      {
        "slug": "il12a",
        "symbol": "IL12A",
        "hgnc": "HGNC:5969",
        "name": "interleukin 12A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il12a"
      },
      {
        "slug": "il12a-as1",
        "symbol": "IL12A-AS1",
        "hgnc": "HGNC:49094",
        "name": "IL12A antisense RNA 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il12a-as1"
      },
      {
        "slug": "il23r",
        "symbol": "IL23R",
        "hgnc": "HGNC:19100",
        "name": "interleukin 23 receptor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il23r"
      },
      {
        "slug": "irf4",
        "symbol": "IRF4",
        "hgnc": "HGNC:6119",
        "name": "interferon regulatory factor 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/irf4"
      },
      {
        "slug": "klrc4",
        "symbol": "KLRC4",
        "hgnc": "HGNC:6377",
        "name": "killer cell lectin like receptor C4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/klrc4"
      },
      {
        "slug": "pstpip1",
        "symbol": "PSTPIP1",
        "hgnc": "HGNC:9580",
        "name": "proline-serine-threonine phosphatase interacting protein 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pstpip1"
      },
      {
        "slug": "stat4",
        "symbol": "STAT4",
        "hgnc": "HGNC:11365",
        "name": "signal transducer and activator of transcription 4",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/stat4"
      },
      {
        "slug": "tlr4",
        "symbol": "TLR4",
        "hgnc": "HGNC:11850",
        "name": "toll like receptor 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tlr4"
      },
      {
        "slug": "tnfrsf1a",
        "symbol": "TNFRSF1A",
        "hgnc": "HGNC:11916",
        "name": "TNF receptor superfamily member 1A",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tnfrsf1a"
      },
      {
        "slug": "ubac2",
        "symbol": "UBAC2",
        "hgnc": "HGNC:20486",
        "name": "UBA domain containing 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ubac2"
      },
      {
        "slug": "adar",
        "symbol": "ADAR",
        "hgnc": "HGNC:225",
        "name": "adenosine deaminase RNA specific",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/adar"
      },
      {
        "slug": "foxp3",
        "symbol": "FOXP3",
        "hgnc": "HGNC:6106",
        "name": "forkhead box P3",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/foxp3"
      },
      {
        "slug": "ifih1",
        "symbol": "IFIH1",
        "hgnc": "HGNC:18873",
        "name": "interferon induced with helicase C domain 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ifih1"
      },
      {
        "slug": "irak1",
        "symbol": "IRAK1",
        "hgnc": "HGNC:6112",
        "name": "interleukin 1 receptor associated kinase 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/irak1"
      },
      {
        "slug": "lsm11",
        "symbol": "LSM11",
        "hgnc": "HGNC:30860",
        "name": "LSM11, U7 small nuclear RNA associated",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lsm11"
      },
      {
        "slug": "rnaseh2a",
        "symbol": "RNASEH2A",
        "hgnc": "HGNC:18518",
        "name": "ribonuclease H2 subunit A",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnaseh2a"
      },
      {
        "slug": "rnaseh2b",
        "symbol": "RNASEH2B",
        "hgnc": "HGNC:25671",
        "name": "ribonuclease H2 subunit B",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnaseh2b"
      },
      {
        "slug": "rnaseh2c",
        "symbol": "RNASEH2C",
        "hgnc": "HGNC:24116",
        "name": "ribonuclease H2 subunit C",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnaseh2c"
      },
      {
        "slug": "rnu7-1",
        "symbol": "RNU7-1",
        "hgnc": "HGNC:34033",
        "name": "RNA, U7 small nuclear 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnu7-1"
      },
      {
        "slug": "samhd1",
        "symbol": "SAMHD1",
        "hgnc": "HGNC:15925",
        "name": "SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/samhd1"
      },
      {
        "slug": "sat1",
        "symbol": "SAT1",
        "hgnc": "HGNC:10540",
        "name": "spermidine/spermine N1-acetyltransferase 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sat1"
      },
      {
        "slug": "spp1",
        "symbol": "SPP1",
        "hgnc": "HGNC:11255",
        "name": "secreted phosphoprotein 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spp1"
      },
      {
        "slug": "trex1",
        "symbol": "TREX1",
        "hgnc": "HGNC:12269",
        "name": "three prime repair exonuclease 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trex1"
      },
      {
        "slug": "capn3",
        "symbol": "CAPN3",
        "hgnc": "HGNC:1480",
        "name": "calpain 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/capn3"
      },
      {
        "slug": "hnrnpa2b1",
        "symbol": "HNRNPA2B1",
        "hgnc": "HGNC:5033",
        "name": "heterogeneous nuclear ribonucleoprotein A2/B1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hnrnpa2b1"
      },
      {
        "slug": "psmb4",
        "symbol": "PSMB4",
        "hgnc": "HGNC:9541",
        "name": "proteasome 20S subunit beta 4",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/psmb4"
      }
    ]
  }
}