{
  "url": "https://dantelabs.com/traits/myocardial-sarcomeric-disarray",
  "trait": {
    "bundleId": "2026.10.18-8b139e39",
    "release": "2026-09-01",
    "slug": "myocardial-sarcomeric-disarray",
    "id": "HP:0031333",
    "name": "Myocardial sarcomeric disarray",
    "definition": "A disruption of the structure of the sarcomeres of cardiomyocytes. The sarcomere is the repeating unit between two Z lines comprised largely of myosin and actin that mediates contractility, and normally sarcomeres are aligned with the long axis of cells, with the Z bands being in register throughout the length of the cardiac myocytes.",
    "synonyms": [
      "Cardiac biopsy: myocyte disarray",
      "Cardiomyocyte disarray",
      "Myocardial sarcomere disarray"
    ],
    "systems": [
      {
        "slug": "abnormal-cellular-phenotype",
        "name": "Abnormal cellular phenotype",
        "url": "https://dantelabs.com/traits/abnormal-cellular-phenotype"
      },
      {
        "slug": "abnormality-of-the-cardiovascular-system",
        "name": "Abnormality of the cardiovascular system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-cardiovascular-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-cardiomyocyte-morphology",
        "name": "Abnormal cardiomyocyte morphology",
        "url": "https://dantelabs.com/traits/abnormal-cardiomyocyte-morphology"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "tnnt2",
        "symbol": "TNNT2",
        "hgnc": "HGNC:11949",
        "name": "troponin T2, cardiac type",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnnt2"
      },
      {
        "slug": "lmod2",
        "symbol": "LMOD2",
        "hgnc": "HGNC:6648",
        "name": "leiomodin 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmod2"
      }
    ]
  }
}