{
  "url": "https://dantelabs.com/traits/muscle-flaccidity",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "muscle-flaccidity",
    "id": "HP:0010547",
    "name": "Muscle flaccidity",
    "definition": "A type of paralysis in which a muscle becomes soft and yields to passive stretching, which results from loss of all or practically all peripheral motor nerves that innervated the muscle. Muscle tone is reduced and the affected muscles undergo extreme atrophy within months of the loss of innervation.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "muscle-weakness",
        "name": "Muscle weakness",
        "url": "https://dantelabs.com/traits/muscle-weakness"
      }
    ],
    "narrower": [
      {
        "slug": "episodic-flaccid-weakness",
        "name": "Episodic flaccid weakness",
        "genes": 7,
        "url": "https://dantelabs.com/traits/episodic-flaccid-weakness"
      }
    ],
    "genes": [
      {
        "slug": "mpv17",
        "symbol": "MPV17",
        "hgnc": "HGNC:7224",
        "name": "mitochondrial inner membrane protein MPV17",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mpv17"
      },
      {
        "slug": "lamp2",
        "symbol": "LAMP2",
        "hgnc": "HGNC:6501",
        "name": "lysosome associated membrane protein 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lamp2"
      },
      {
        "slug": "plec",
        "symbol": "PLEC",
        "hgnc": "HGNC:9069",
        "name": "plectin",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plec"
      },
      {
        "slug": "sil1",
        "symbol": "SIL1",
        "hgnc": "HGNC:24624",
        "name": "SIL1 nucleotide exchange factor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sil1"
      },
      {
        "slug": "ube3b",
        "symbol": "UBE3B",
        "hgnc": "HGNC:13478",
        "name": "ubiquitin protein ligase E3B",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ube3b"
      },
      {
        "slug": "pex1",
        "symbol": "PEX1",
        "hgnc": "HGNC:8850",
        "name": "peroxisomal biogenesis factor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pex1"
      },
      {
        "slug": "pex6",
        "symbol": "PEX6",
        "hgnc": "HGNC:8859",
        "name": "peroxisomal biogenesis factor 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pex6"
      }
    ]
  }
}