{
  "url": "https://dantelabs.com/traits/hypouricemia",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "hypouricemia",
    "id": "HP:0003537",
    "name": "Low blood uric acid levels",
    "label": "Hypouricemia",
    "definition": "The concentration of uric acid in the blood circulation is below the lower limit of normal.",
    "synonyms": [
      "Decreased uric acid concentration",
      "Decreased uric acid level",
      "Decreased uric acid level in blood",
      "Reduced uric acid concentration",
      "Reduced uric acid level",
      "Reduced uric acid level in blood"
    ],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-circulating-nucleobase-concentration",
        "name": "Abnormal circulating nucleobase concentration",
        "url": "https://dantelabs.com/traits/abnormal-circulating-nucleobase-concentration"
      },
      {
        "slug": "azotemia",
        "name": "Azotemia",
        "url": "https://dantelabs.com/traits/azotemia"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "atp7b",
        "symbol": "ATP7B",
        "hgnc": "HGNC:870",
        "name": "ATPase copper transporting beta",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp7b"
      },
      {
        "slug": "gphn",
        "symbol": "GPHN",
        "hgnc": "HGNC:15465",
        "name": "gephyrin",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gphn"
      },
      {
        "slug": "mocos",
        "symbol": "MOCOS",
        "hgnc": "HGNC:18234",
        "name": "molybdenum cofactor sulfurase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mocos"
      },
      {
        "slug": "mocs2",
        "symbol": "MOCS2",
        "hgnc": "HGNC:7193",
        "name": "molybdenum cofactor synthesis 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mocs2"
      },
      {
        "slug": "pnp",
        "symbol": "PNP",
        "hgnc": "HGNC:7892",
        "name": "purine nucleoside phosphorylase",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pnp"
      },
      {
        "slug": "slc22a12",
        "symbol": "SLC22A12",
        "hgnc": "HGNC:17989",
        "name": "solute carrier family 22 member 12",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/slc22a12"
      },
      {
        "slug": "slc2a9",
        "symbol": "SLC2A9",
        "hgnc": "HGNC:13446",
        "name": "solute carrier family 2 member 9",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/slc2a9"
      },
      {
        "slug": "xdh",
        "symbol": "XDH",
        "hgnc": "HGNC:12805",
        "name": "xanthine dehydrogenase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/xdh"
      },
      {
        "slug": "ehhadh",
        "symbol": "EHHADH",
        "hgnc": "HGNC:3247",
        "name": "enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ehhadh"
      },
      {
        "slug": "gatm",
        "symbol": "GATM",
        "hgnc": "HGNC:4175",
        "name": "glycine amidinotransferase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gatm"
      },
      {
        "slug": "ndufaf6",
        "symbol": "NDUFAF6",
        "hgnc": "HGNC:28625",
        "name": "NADH:ubiquinone oxidoreductase complex assembly factor 6",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufaf6"
      },
      {
        "slug": "prps1",
        "symbol": "PRPS1",
        "hgnc": "HGNC:9462",
        "name": "phosphoribosyl pyrophosphate synthetase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prps1"
      },
      {
        "slug": "slc34a1",
        "symbol": "SLC34A1",
        "hgnc": "HGNC:11019",
        "name": "solute carrier family 34 member 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc34a1"
      },
      {
        "slug": "ctns",
        "symbol": "CTNS",
        "hgnc": "HGNC:2518",
        "name": "cystinosin, lysosomal cystine transporter",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctns"
      },
      {
        "slug": "hnf4a",
        "symbol": "HNF4A",
        "hgnc": "HGNC:5024",
        "name": "hepatocyte nuclear factor 4 alpha",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hnf4a"
      },
      {
        "slug": "mocs1",
        "symbol": "MOCS1",
        "hgnc": "HGNC:7190",
        "name": "molybdenum cofactor synthesis 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mocs1"
      },
      {
        "slug": "slc2a2",
        "symbol": "SLC2A2",
        "hgnc": "HGNC:11006",
        "name": "solute carrier family 2 member 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc2a2"
      }
    ]
  }
}