{
  "url": "https://dantelabs.com/traits/hydroxyprolinemia",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "hydroxyprolinemia",
    "id": "HP:0003260",
    "name": "High blood hydroxyproline levels",
    "label": "Hydroxyprolinemia",
    "definition": "The concentration of hydroxyproline in the blood circulation is above the upper limit of normal.",
    "synonyms": [
      "Elevated hydroxyproline concentration",
      "Elevated hydroxyproline level",
      "Elevated hydroxyproline level in blood",
      "Increased hydroxyproline concentration",
      "Increased hydroxyproline level",
      "Increased hydroxyproline level in blood"
    ],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-circulating-proline-concentration",
        "name": "Abnormal circulating proline concentration",
        "url": "https://dantelabs.com/traits/abnormal-circulating-proline-concentration"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "prodh2",
        "symbol": "PRODH2",
        "hgnc": "HGNC:17325",
        "name": "proline dehydrogenase 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prodh2"
      },
      {
        "slug": "slc36a2",
        "symbol": "SLC36A2",
        "hgnc": "HGNC:18762",
        "name": "solute carrier family 36 member 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc36a2"
      },
      {
        "slug": "slc6a18",
        "symbol": "SLC6A18",
        "hgnc": "HGNC:26441",
        "name": "solute carrier family 6 member 18",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc6a18"
      },
      {
        "slug": "slc6a19",
        "symbol": "SLC6A19",
        "hgnc": "HGNC:27960",
        "name": "solute carrier family 6 member 19",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc6a19"
      },
      {
        "slug": "slc6a20",
        "symbol": "SLC6A20",
        "hgnc": "HGNC:30927",
        "name": "solute carrier family 6 member 20",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc6a20"
      },
      {
        "slug": "tnfrsf11b",
        "symbol": "TNFRSF11B",
        "hgnc": "HGNC:11909",
        "name": "TNF receptor superfamily member 11b",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnfrsf11b"
      }
    ]
  }
}