{
  "url": "https://dantelabs.com/traits/hemoglobinuria",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "hemoglobinuria",
    "id": "HP:0003641",
    "name": "Hemoglobin in urine",
    "label": "Hemoglobinuria",
    "definition": "The presence of free hemoglobin in the urine.",
    "synonyms": [
      "Haemoglobin in urine"
    ],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      },
      {
        "slug": "abnormality-of-the-genitourinary-system",
        "name": "Abnormality of the genitourinary system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-genitourinary-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-urine-metabolite-level",
        "name": "Abnormal urine metabolite level",
        "url": "https://dantelabs.com/traits/abnormal-urine-metabolite-level"
      }
    ],
    "narrower": [
      {
        "slug": "paroxysmal-nocturnal-hemoglobinuria",
        "name": "Paroxysmal nocturnal hemoglobinuria",
        "genes": 3,
        "url": "https://dantelabs.com/traits/paroxysmal-nocturnal-hemoglobinuria"
      }
    ],
    "genes": [
      {
        "slug": "aldoa",
        "symbol": "ALDOA",
        "hgnc": "HGNC:414",
        "name": "aldolase, fructose-bisphosphate A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aldoa"
      },
      {
        "slug": "piga",
        "symbol": "PIGA",
        "hgnc": "HGNC:8957",
        "name": "phosphatidylinositol glycan anchor biosynthesis class A",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/piga"
      },
      {
        "slug": "cd46",
        "symbol": "CD46",
        "hgnc": "HGNC:6953",
        "name": "CD46 molecule",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd46"
      },
      {
        "slug": "cfh",
        "symbol": "CFH",
        "hgnc": "HGNC:4883",
        "name": "complement factor H",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfh"
      },
      {
        "slug": "cfi",
        "symbol": "CFI",
        "hgnc": "HGNC:5394",
        "name": "complement factor I",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfi"
      },
      {
        "slug": "hellpar",
        "symbol": "HELLPAR",
        "hgnc": "HGNC:43984",
        "name": "HELLP associated long non-coding RNA",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hellpar"
      },
      {
        "slug": "nt5c3a",
        "symbol": "NT5C3A",
        "hgnc": "HGNC:17820",
        "name": "5'-nucleotidase, cytosolic IIIA",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nt5c3a"
      },
      {
        "slug": "piezo1",
        "symbol": "PIEZO1",
        "hgnc": "HGNC:28993",
        "name": "piezo type mechanosensitive ion channel component 1 (Er blood group)",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/piezo1"
      },
      {
        "slug": "cask",
        "symbol": "CASK",
        "hgnc": "HGNC:1497",
        "name": "calcium/calmodulin dependent serine protein kinase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cask"
      },
      {
        "slug": "g6pd",
        "symbol": "G6PD",
        "hgnc": "HGNC:4057",
        "name": "glucose-6-phosphate dehydrogenase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/g6pd"
      }
    ]
  }
}