{
  "url": "https://dantelabs.com/traits/hbs-hemoglobin",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "hbs-hemoglobin",
    "id": "HP:0045047",
    "name": "HbS hemoglobin",
    "definition": "Presence of an abnormal type of hemoglobin characterized by the substitution of a glutamic acid residue at position 7 following the initial methionine residue by a valine (the mutation causative of sickle cell disease). The mutation promotes the polymerization of the HbS under conditions of low oxygen concentration. HbS can be identified by multiple methodologies including hemoglobin electrophoresis and high-performance liquid chromatography.",
    "synonyms": [
      "HbS haemoglobin"
    ],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-hemoglobin",
        "name": "Abnormal hemoglobin",
        "url": "https://dantelabs.com/traits/abnormal-hemoglobin"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "bcl11a",
        "symbol": "BCL11A",
        "hgnc": "HGNC:13221",
        "name": "BCL11 transcription factor A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bcl11a"
      },
      {
        "slug": "hbb",
        "symbol": "HBB",
        "hgnc": "HGNC:4827",
        "name": "hemoglobin subunit beta",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/hbb"
      },
      {
        "slug": "hbg1",
        "symbol": "HBG1",
        "hgnc": "HGNC:4831",
        "name": "hemoglobin subunit gamma 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hbg1"
      },
      {
        "slug": "hbg2",
        "symbol": "HBG2",
        "hgnc": "HGNC:4832",
        "name": "hemoglobin subunit gamma 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hbg2"
      },
      {
        "slug": "klf1",
        "symbol": "KLF1",
        "hgnc": "HGNC:6345",
        "name": "KLF transcription factor 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/klf1"
      }
    ]
  }
}