{
  "url": "https://dantelabs.com/traits/gingival-bleeding",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "gingival-bleeding",
    "id": "HP:0000225",
    "name": "Bleeding gums",
    "label": "Gingival bleeding",
    "definition": "Hemorrhage affecting the gingiva.",
    "synonyms": [
      "Gingival haemorrhage",
      "Gingival hemorrhage",
      "Gingivorrhagia"
    ],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      },
      {
        "slug": "abnormality-of-head-or-neck",
        "name": "Abnormality of head or neck",
        "url": "https://dantelabs.com/traits/abnormality-of-head-or-neck"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-gingiva-morphology",
        "name": "Abnormality of the gums",
        "url": "https://dantelabs.com/traits/abnormal-gingiva-morphology"
      },
      {
        "slug": "abnormal-bleeding",
        "name": "Bleeding tendency",
        "url": "https://dantelabs.com/traits/abnormal-bleeding"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "adamts2",
        "symbol": "ADAMTS2",
        "hgnc": "HGNC:218",
        "name": "ADAM metallopeptidase with thrombospondin type 1 motif 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/adamts2"
      },
      {
        "slug": "elmo2",
        "symbol": "ELMO2",
        "hgnc": "HGNC:17233",
        "name": "engulfment and cell motility 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/elmo2"
      },
      {
        "slug": "f13a1",
        "symbol": "F13A1",
        "hgnc": "HGNC:3531",
        "name": "coagulation factor XIII A chain",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/f13a1"
      },
      {
        "slug": "gale",
        "symbol": "GALE",
        "hgnc": "HGNC:4116",
        "name": "UDP-galactose-4-epimerase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gale"
      },
      {
        "slug": "ggcx",
        "symbol": "GGCX",
        "hgnc": "HGNC:4247",
        "name": "gamma-glutamyl carboxylase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ggcx"
      },
      {
        "slug": "hivep2",
        "symbol": "HIVEP2",
        "hgnc": "HGNC:4921",
        "name": "HIVEP zinc finger 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hivep2"
      },
      {
        "slug": "hps3",
        "symbol": "HPS3",
        "hgnc": "HGNC:15597",
        "name": "HPS3 biogenesis of lysosomal organelles complex 2 subunit 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hps3"
      },
      {
        "slug": "il18bp",
        "symbol": "IL18BP",
        "hgnc": "HGNC:5987",
        "name": "interleukin 18 binding protein",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il18bp"
      },
      {
        "slug": "plcg1",
        "symbol": "PLCG1",
        "hgnc": "HGNC:9065",
        "name": "phospholipase C gamma 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plcg1"
      },
      {
        "slug": "c1r",
        "symbol": "C1R",
        "hgnc": "HGNC:1246",
        "name": "complement C1r",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/c1r"
      },
      {
        "slug": "c1s",
        "symbol": "C1S",
        "hgnc": "HGNC:1247",
        "name": "complement C1s",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/c1s"
      },
      {
        "slug": "fga",
        "symbol": "FGA",
        "hgnc": "HGNC:3661",
        "name": "fibrinogen alpha chain",
        "frequency": "very-frequent",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/fga"
      },
      {
        "slug": "fgb",
        "symbol": "FGB",
        "hgnc": "HGNC:3662",
        "name": "fibrinogen beta chain",
        "frequency": "very-frequent",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/fgb"
      },
      {
        "slug": "fgg",
        "symbol": "FGG",
        "hgnc": "HGNC:3694",
        "name": "fibrinogen gamma chain",
        "frequency": "very-frequent",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/fgg"
      },
      {
        "slug": "jak2",
        "symbol": "JAK2",
        "hgnc": "HGNC:6192",
        "name": "Janus kinase 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/jak2"
      },
      {
        "slug": "lyst",
        "symbol": "LYST",
        "hgnc": "HGNC:1968",
        "name": "lysosomal trafficking regulator",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/lyst"
      },
      {
        "slug": "bcor",
        "symbol": "BCOR",
        "hgnc": "HGNC:20893",
        "name": "BCL6 corepressor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bcor"
      },
      {
        "slug": "bloc1s5",
        "symbol": "BLOC1S5",
        "hgnc": "HGNC:18561",
        "name": "biogenesis of lysosomal organelles complex 1 subunit 5",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bloc1s5"
      },
      {
        "slug": "f10",
        "symbol": "F10",
        "hgnc": "HGNC:3528",
        "name": "coagulation factor X",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/f10"
      },
      {
        "slug": "f7",
        "symbol": "F7",
        "hgnc": "HGNC:3544",
        "name": "coagulation factor VII",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/f7"
      },
      {
        "slug": "f8",
        "symbol": "F8",
        "hgnc": "HGNC:3546",
        "name": "coagulation factor VIII",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/f8"
      },
      {
        "slug": "fip1l1",
        "symbol": "FIP1L1",
        "hgnc": "HGNC:19124",
        "name": "factor interacting with PAPOLA and CPSF1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fip1l1"
      },
      {
        "slug": "gba1",
        "symbol": "GBA1",
        "hgnc": "HGNC:4177",
        "name": "glucosylceramidase beta 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gba1"
      },
      {
        "slug": "irf2bp2",
        "symbol": "IRF2BP2",
        "hgnc": "HGNC:21729",
        "name": "interferon regulatory factor 2 binding protein 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/irf2bp2"
      },
      {
        "slug": "itga2b",
        "symbol": "ITGA2B",
        "hgnc": "HGNC:6138",
        "name": "integrin subunit alpha 2b",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/itga2b"
      },
      {
        "slug": "itgb3",
        "symbol": "ITGB3",
        "hgnc": "HGNC:6156",
        "name": "integrin subunit beta 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/itgb3"
      },
      {
        "slug": "lman1",
        "symbol": "LMAN1",
        "hgnc": "HGNC:6631",
        "name": "lectin, mannose binding 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lman1"
      },
      {
        "slug": "mcfd2",
        "symbol": "MCFD2",
        "hgnc": "HGNC:18451",
        "name": "multiple coagulation factor deficiency 2, ER cargo receptor complex subunit",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mcfd2"
      },
      {
        "slug": "myd88",
        "symbol": "MYD88",
        "hgnc": "HGNC:7562",
        "name": "MYD88 innate immune signal transduction adaptor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/myd88"
      },
      {
        "slug": "nabp1",
        "symbol": "NABP1",
        "hgnc": "HGNC:26232",
        "name": "nucleic acid binding protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nabp1"
      },
      {
        "slug": "npm1",
        "symbol": "NPM1",
        "hgnc": "HGNC:7910",
        "name": "nucleophosmin 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/npm1"
      },
      {
        "slug": "numa1",
        "symbol": "NUMA1",
        "hgnc": "HGNC:8059",
        "name": "nuclear mitotic apparatus protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/numa1"
      },
      {
        "slug": "pml",
        "symbol": "PML",
        "hgnc": "HGNC:9113",
        "name": "PML nuclear body scaffold",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pml"
      },
      {
        "slug": "prkar1a",
        "symbol": "PRKAR1A",
        "hgnc": "HGNC:9388",
        "name": "protein kinase cAMP-dependent type I regulatory subunit alpha",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prkar1a"
      },
      {
        "slug": "rara",
        "symbol": "RARA",
        "hgnc": "HGNC:9864",
        "name": "retinoic acid receptor alpha",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rara"
      },
      {
        "slug": "scarb2",
        "symbol": "SCARB2",
        "hgnc": "HGNC:1665",
        "name": "scavenger receptor class B member 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scarb2"
      },
      {
        "slug": "stat3",
        "symbol": "STAT3",
        "hgnc": "HGNC:11364",
        "name": "signal transducer and activator of transcription 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stat3"
      },
      {
        "slug": "stat5b",
        "symbol": "STAT5B",
        "hgnc": "HGNC:11367",
        "name": "signal transducer and activator of transcription 5B",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stat5b"
      },
      {
        "slug": "tbl1xr1",
        "symbol": "TBL1XR1",
        "hgnc": "HGNC:29529",
        "name": "TBL1X/Y related 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbl1xr1"
      },
      {
        "slug": "zbtb16",
        "symbol": "ZBTB16",
        "hgnc": "HGNC:12930",
        "name": "zinc finger and BTB domain containing 16",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zbtb16"
      },
      {
        "slug": "ano6",
        "symbol": "ANO6",
        "hgnc": "HGNC:25240",
        "name": "anoctamin 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ano6"
      },
      {
        "slug": "cat",
        "symbol": "CAT",
        "hgnc": "HGNC:1516",
        "name": "catalase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cat"
      },
      {
        "slug": "f13b",
        "symbol": "F13B",
        "hgnc": "HGNC:3534",
        "name": "coagulation factor XIII B chain",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/f13b"
      },
      {
        "slug": "f5",
        "symbol": "F5",
        "hgnc": "HGNC:3542",
        "name": "coagulation factor V",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/f5"
      },
      {
        "slug": "fcgr2c",
        "symbol": "FCGR2C",
        "hgnc": "HGNC:15626",
        "name": "Fc gamma receptor IIc (gene/pseudogene)",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fcgr2c"
      },
      {
        "slug": "fyb1",
        "symbol": "FYB1",
        "hgnc": "HGNC:4036",
        "name": "FYN binding protein 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fyb1"
      },
      {
        "slug": "gp1ba",
        "symbol": "GP1BA",
        "hgnc": "HGNC:4439",
        "name": "glycoprotein Ib platelet subunit alpha",
        "frequency": "occasional",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/gp1ba"
      },
      {
        "slug": "gp1bb",
        "symbol": "GP1BB",
        "hgnc": "HGNC:4440",
        "name": "glycoprotein Ib platelet subunit beta",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gp1bb"
      },
      {
        "slug": "gp9",
        "symbol": "GP9",
        "hgnc": "HGNC:4444",
        "name": "glycoprotein IX platelet",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gp9"
      },
      {
        "slug": "ifng",
        "symbol": "IFNG",
        "hgnc": "HGNC:5438",
        "name": "interferon gamma",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ifng"
      },
      {
        "slug": "kif23",
        "symbol": "KIF23",
        "hgnc": "HGNC:6392",
        "name": "kinesin family member 23",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kif23"
      },
      {
        "slug": "prf1",
        "symbol": "PRF1",
        "hgnc": "HGNC:9360",
        "name": "perforin 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prf1"
      },
      {
        "slug": "racgap1",
        "symbol": "RACGAP1",
        "hgnc": "HGNC:9804",
        "name": "Rac GTPase activating protein 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/racgap1"
      },
      {
        "slug": "sbds",
        "symbol": "SBDS",
        "hgnc": "HGNC:19440",
        "name": "SBDS ribosome maturation factor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sbds"
      },
      {
        "slug": "serpinf2",
        "symbol": "SERPINF2",
        "hgnc": "HGNC:9075",
        "name": "serpin family F member 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/serpinf2"
      },
      {
        "slug": "terc",
        "symbol": "TERC",
        "hgnc": "HGNC:11727",
        "name": "telomerase RNA component",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/terc"
      },
      {
        "slug": "tert",
        "symbol": "TERT",
        "hgnc": "HGNC:11730",
        "name": "telomerase reverse transcriptase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tert"
      },
      {
        "slug": "was",
        "symbol": "WAS",
        "hgnc": "HGNC:12731",
        "name": "WASP actin nucleation promoting factor",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/was"
      },
      {
        "slug": "bloc1s3",
        "symbol": "BLOC1S3",
        "hgnc": "HGNC:20914",
        "name": "biogenesis of lysosomal organelles complex 1 subunit 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bloc1s3"
      },
      {
        "slug": "f2",
        "symbol": "F2",
        "hgnc": "HGNC:3535",
        "name": "coagulation factor II, thrombin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/f2"
      },
      {
        "slug": "hps1",
        "symbol": "HPS1",
        "hgnc": "HGNC:5163",
        "name": "HPS1 biogenesis of lysosomal organelles complex 3 subunit 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hps1"
      }
    ]
  }
}