{
  "url": "https://dantelabs.com/traits/foam-cells",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "foam-cells",
    "id": "HP:0003651",
    "name": "Foam cells",
    "definition": "The presence of foam cells, a type of macrophage that localizes to fatty deposits on blood vessel walls, where they ingest low-density lipoproteins and become laden with lipids, giving them a foamy appearance.",
    "synonyms": [
      "Foamy histiocytes",
      "Foamy macrophages",
      "Lipid-laden histiocytes",
      "Presence of foam cells"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-cardiovascular-system",
        "name": "Abnormality of the cardiovascular system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-cardiovascular-system"
      }
    ],
    "broader": [
      {
        "slug": "atherosclerosis",
        "name": "Narrowing and hardening of arteries",
        "url": "https://dantelabs.com/traits/atherosclerosis"
      }
    ],
    "narrower": [
      {
        "slug": "bone-marrow-foam-cells",
        "name": "Bone-marrow foam cells",
        "genes": 5,
        "url": "https://dantelabs.com/traits/bone-marrow-foam-cells"
      },
      {
        "slug": "cns-foam-cells",
        "name": "CNS foam cells",
        "genes": 3,
        "url": "https://dantelabs.com/traits/cns-foam-cells"
      },
      {
        "slug": "foam-cells-with-lamellar-inclusion-bodies",
        "name": "Foam cells with lamellar inclusion bodies",
        "genes": 1,
        "url": "https://dantelabs.com/traits/foam-cells-with-lamellar-inclusion-bodies"
      },
      {
        "slug": "hepatic-foam-cells",
        "name": "Hepatic foam cells",
        "genes": 1,
        "url": "https://dantelabs.com/traits/hepatic-foam-cells"
      },
      {
        "slug": "renal-interstitial-foam-cells",
        "name": "Renal interstitial foam cells",
        "genes": 1,
        "url": "https://dantelabs.com/traits/renal-interstitial-foam-cells"
      }
    ],
    "genes": [
      {
        "slug": "apoe",
        "symbol": "APOE",
        "hgnc": "HGNC:613",
        "name": "apolipoprotein E",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/apoe"
      },
      {
        "slug": "pik3cg",
        "symbol": "PIK3CG",
        "hgnc": "HGNC:8978",
        "name": "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pik3cg"
      },
      {
        "slug": "rbsn",
        "symbol": "RBSN",
        "hgnc": "HGNC:20759",
        "name": "rabenosyn, RAB effector",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rbsn"
      },
      {
        "slug": "hla-drb1",
        "symbol": "HLA-DRB1",
        "hgnc": "HGNC:4948",
        "name": "major histocompatibility complex, class II, DR beta 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hla-drb1"
      },
      {
        "slug": "csf2ra",
        "symbol": "CSF2RA",
        "hgnc": "HGNC:2435",
        "name": "colony stimulating factor 2 receptor subunit alpha",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/csf2ra"
      },
      {
        "slug": "csf2rb",
        "symbol": "CSF2RB",
        "hgnc": "HGNC:2436",
        "name": "colony stimulating factor 2 receptor subunit beta",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/csf2rb"
      },
      {
        "slug": "nsdhl",
        "symbol": "NSDHL",
        "hgnc": "HGNC:13398",
        "name": "NAD(P) dependent 3-beta-hydroxysteroid dehydrogenase NSDHL",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nsdhl"
      },
      {
        "slug": "glb1",
        "symbol": "GLB1",
        "hgnc": "HGNC:4298",
        "name": "galactosidase beta 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/glb1"
      },
      {
        "slug": "lcat",
        "symbol": "LCAT",
        "hgnc": "HGNC:6522",
        "name": "lecithin-cholesterol acyltransferase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lcat"
      },
      {
        "slug": "npc1",
        "symbol": "NPC1",
        "hgnc": "HGNC:7897",
        "name": "NPC intracellular cholesterol transporter 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/npc1"
      },
      {
        "slug": "npc2",
        "symbol": "NPC2",
        "hgnc": "HGNC:14537",
        "name": "NPC intracellular cholesterol transporter 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/npc2"
      }
    ]
  }
}