{
  "url": "https://dantelabs.com/traits/exaggerated-startle-response",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "exaggerated-startle-response",
    "id": "HP:0002267",
    "name": "Exaggerated startle response",
    "definition": "An exaggerated startle reaction in response to a sudden unexpected visual or acoustic stimulus, or a quick movement near the face.",
    "synonyms": [
      "Exaggerated acoustic startle response",
      "Increased startle response"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-extrapyramidal-motor-function",
        "name": "Abnormality of extrapyramidal motor function",
        "url": "https://dantelabs.com/traits/abnormality-of-extrapyramidal-motor-function"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "arhgef9",
        "symbol": "ARHGEF9",
        "hgnc": "HGNC:14561",
        "name": "Cdc42 guanine nucleotide exchange factor 9",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/arhgef9"
      },
      {
        "slug": "brat1",
        "symbol": "BRAT1",
        "hgnc": "HGNC:21701",
        "name": "BRCA1 associated ATM activator 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/brat1"
      },
      {
        "slug": "dnm1l",
        "symbol": "DNM1L",
        "hgnc": "HGNC:2973",
        "name": "dynamin 1L",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnm1l"
      },
      {
        "slug": "gcsh",
        "symbol": "GCSH",
        "hgnc": "HGNC:4208",
        "name": "glycine cleavage system protein H",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gcsh"
      },
      {
        "slug": "glrb",
        "symbol": "GLRB",
        "hgnc": "HGNC:4329",
        "name": "glycine receptor beta",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/glrb"
      },
      {
        "slug": "gm2a",
        "symbol": "GM2A",
        "hgnc": "HGNC:4367",
        "name": "ganglioside GM2 activator",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gm2a"
      },
      {
        "slug": "hexb",
        "symbol": "HEXB",
        "hgnc": "HGNC:4879",
        "name": "hexosaminidase subunit beta",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/hexb"
      },
      {
        "slug": "klc2",
        "symbol": "KLC2",
        "hgnc": "HGNC:20716",
        "name": "kinesin light chain 2",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/klc2"
      },
      {
        "slug": "med16",
        "symbol": "MED16",
        "hgnc": "HGNC:17556",
        "name": "mediator complex subunit 16",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/med16"
      },
      {
        "slug": "mthfs",
        "symbol": "MTHFS",
        "hgnc": "HGNC:7437",
        "name": "methenyltetrahydrofolate synthetase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mthfs"
      },
      {
        "slug": "piga",
        "symbol": "PIGA",
        "hgnc": "HGNC:8957",
        "name": "phosphatidylinositol glycan anchor biosynthesis class A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/piga"
      },
      {
        "slug": "plaa",
        "symbol": "PLAA",
        "hgnc": "HGNC:9043",
        "name": "phospholipase A2 activating protein",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/plaa"
      },
      {
        "slug": "slc6a5",
        "symbol": "SLC6A5",
        "hgnc": "HGNC:11051",
        "name": "solute carrier family 6 member 5",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc6a5"
      },
      {
        "slug": "sod1",
        "symbol": "SOD1",
        "hgnc": "HGNC:11179",
        "name": "superoxide dismutase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sod1"
      },
      {
        "slug": "tspyl1",
        "symbol": "TSPYL1",
        "hgnc": "HGNC:12382",
        "name": "TSPY like 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tspyl1"
      },
      {
        "slug": "asns",
        "symbol": "ASNS",
        "hgnc": "HGNC:753",
        "name": "asparagine synthetase (glutamine-hydrolyzing)",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/asns"
      },
      {
        "slug": "ddc",
        "symbol": "DDC",
        "hgnc": "HGNC:2719",
        "name": "dopa decarboxylase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ddc"
      },
      {
        "slug": "dennd5a",
        "symbol": "DENND5A",
        "hgnc": "HGNC:19344",
        "name": "DENN domain containing 5A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dennd5a"
      },
      {
        "slug": "flrt1",
        "symbol": "FLRT1",
        "hgnc": "HGNC:3760",
        "name": "fibronectin leucine rich transmembrane protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/flrt1"
      },
      {
        "slug": "fth1",
        "symbol": "FTH1",
        "hgnc": "HGNC:3976",
        "name": "ferritin heavy chain 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fth1"
      },
      {
        "slug": "glb1",
        "symbol": "GLB1",
        "hgnc": "HGNC:4298",
        "name": "galactosidase beta 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/glb1"
      },
      {
        "slug": "gria4",
        "symbol": "GRIA4",
        "hgnc": "HGNC:4574",
        "name": "glutamate ionotropic receptor AMPA type subunit 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gria4"
      },
      {
        "slug": "med11",
        "symbol": "MED11",
        "hgnc": "HGNC:32687",
        "name": "mediator complex subunit 11",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/med11"
      },
      {
        "slug": "cacna1i",
        "symbol": "CACNA1I",
        "hgnc": "HGNC:1396",
        "name": "calcium voltage-gated channel subunit alpha1 I",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cacna1i"
      },
      {
        "slug": "fktn",
        "symbol": "FKTN",
        "hgnc": "HGNC:3622",
        "name": "fukutin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fktn"
      },
      {
        "slug": "hikeshi",
        "symbol": "HIKESHI",
        "hgnc": "HGNC:26938",
        "name": "heat shock protein nuclear import factor hikeshi",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hikeshi"
      },
      {
        "slug": "pura",
        "symbol": "PURA",
        "hgnc": "HGNC:9701",
        "name": "purine rich element binding protein A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pura"
      },
      {
        "slug": "rnu5b-1",
        "symbol": "RNU5B-1",
        "hgnc": "HGNC:10212",
        "name": "RNA, U5B small nuclear 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnu5b-1"
      },
      {
        "slug": "tefm",
        "symbol": "TEFM",
        "hgnc": "HGNC:26223",
        "name": "transcription elongation factor, mitochondrial",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tefm"
      },
      {
        "slug": "tnik",
        "symbol": "TNIK",
        "hgnc": "HGNC:30765",
        "name": "TRAF2 and NCK interacting kinase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnik"
      },
      {
        "slug": "zmym2",
        "symbol": "ZMYM2",
        "hgnc": "HGNC:12989",
        "name": "zinc finger MYM-type containing 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zmym2"
      },
      {
        "slug": "aldh3a2",
        "symbol": "ALDH3A2",
        "hgnc": "HGNC:403",
        "name": "aldehyde dehydrogenase 3 family member A2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aldh3a2"
      },
      {
        "slug": "glra1",
        "symbol": "GLRA1",
        "hgnc": "HGNC:4326",
        "name": "glycine receptor alpha 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/glra1"
      },
      {
        "slug": "gphn",
        "symbol": "GPHN",
        "hgnc": "HGNC:15465",
        "name": "gephyrin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gphn"
      },
      {
        "slug": "hexa",
        "symbol": "HEXA",
        "hgnc": "HGNC:4878",
        "name": "hexosaminidase subunit alpha",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hexa"
      },
      {
        "slug": "slc6a9",
        "symbol": "SLC6A9",
        "hgnc": "HGNC:11056",
        "name": "solute carrier family 6 member 9",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc6a9"
      },
      {
        "slug": "trak1",
        "symbol": "TRAK1",
        "hgnc": "HGNC:29947",
        "name": "trafficking kinesin protein 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trak1"
      }
    ]
  }
}