{
  "url": "https://dantelabs.com/traits/broad-thumb",
  "trait": {
    "bundleId": "2026.10.16-c6eea6bf",
    "release": "2026-09-01",
    "slug": "broad-thumb",
    "id": "HP:0011304",
    "name": "Broad thumb",
    "definition": "Increased thumb width without increased dorso-ventral dimension.",
    "synonyms": [
      "Broad thumbs",
      "Wide/broad thumb",
      "Broad phalanges of the thumb",
      "Wide/broad thumb phalanges"
    ],
    "systems": [
      {
        "slug": "abnormality-of-limbs",
        "name": "Abnormality of limbs",
        "url": "https://dantelabs.com/traits/abnormality-of-limbs"
      },
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-thumb-phalanx",
        "name": "Abnormality of the thumb bones",
        "url": "https://dantelabs.com/traits/abnormality-of-thumb-phalanx"
      },
      {
        "slug": "broad-phalanges-of-the-hand",
        "name": "Wide hand bones",
        "url": "https://dantelabs.com/traits/broad-phalanges-of-the-hand"
      }
    ],
    "narrower": [
      {
        "slug": "broad-distal-phalanx-of-the-thumb",
        "name": "Broad outermost bone of the thumb",
        "genes": 4,
        "url": "https://dantelabs.com/traits/broad-distal-phalanx-of-the-thumb"
      },
      {
        "slug": "spatulate-thumbs",
        "name": "Spoon shaped thumbs",
        "genes": 4,
        "url": "https://dantelabs.com/traits/spatulate-thumbs"
      }
    ],
    "genes": [
      {
        "slug": "acan",
        "symbol": "ACAN",
        "hgnc": "HGNC:319",
        "name": "aggrecan",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/acan"
      },
      {
        "slug": "dnm1l",
        "symbol": "DNM1L",
        "hgnc": "HGNC:2973",
        "name": "dynamin 1L",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnm1l"
      },
      {
        "slug": "exosc2",
        "symbol": "EXOSC2",
        "hgnc": "HGNC:17097",
        "name": "exosome component 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/exosc2"
      },
      {
        "slug": "flna",
        "symbol": "FLNA",
        "hgnc": "HGNC:3754",
        "name": "filamin A",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/flna"
      },
      {
        "slug": "gli3",
        "symbol": "GLI3",
        "hgnc": "HGNC:4319",
        "name": "GLI family zinc finger 3",
        "frequency": "obligate",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/gli3"
      },
      {
        "slug": "hyal2",
        "symbol": "HYAL2",
        "hgnc": "HGNC:5321",
        "name": "hyaluronidase 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hyal2"
      },
      {
        "slug": "med12",
        "symbol": "MED12",
        "hgnc": "HGNC:11957",
        "name": "mediator complex subunit 12",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/med12"
      },
      {
        "slug": "mir140",
        "symbol": "MIR140",
        "hgnc": "HGNC:31527",
        "name": "microRNA 140",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mir140"
      },
      {
        "slug": "nxn",
        "symbol": "NXN",
        "hgnc": "HGNC:18008",
        "name": "nucleoredoxin",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nxn"
      },
      {
        "slug": "pan2",
        "symbol": "PAN2",
        "hgnc": "HGNC:20074",
        "name": "poly(A) specific ribonuclease subunit PAN2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pan2"
      },
      {
        "slug": "rere",
        "symbol": "RERE",
        "hgnc": "HGNC:9965",
        "name": "arginine-glutamic acid dipeptide repeats",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rere"
      },
      {
        "slug": "slc13a1",
        "symbol": "SLC13A1",
        "hgnc": "HGNC:10916",
        "name": "solute carrier family 13 member 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc13a1"
      },
      {
        "slug": "snip1",
        "symbol": "SNIP1",
        "hgnc": "HGNC:30587",
        "name": "Smad nuclear interacting protein 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/snip1"
      },
      {
        "slug": "crebbp",
        "symbol": "CREBBP",
        "hgnc": "HGNC:2348",
        "name": "CREB binding lysine acetyltransferase",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/crebbp"
      },
      {
        "slug": "ep300",
        "symbol": "EP300",
        "hgnc": "HGNC:3373",
        "name": "EP300 lysine acetyltransferase",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/ep300"
      },
      {
        "slug": "fgfr1",
        "symbol": "FGFR1",
        "hgnc": "HGNC:3688",
        "name": "fibroblast growth factor receptor 1",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/fgfr1"
      },
      {
        "slug": "fgfr2",
        "symbol": "FGFR2",
        "hgnc": "HGNC:3689",
        "name": "fibroblast growth factor receptor 2",
        "frequency": "very-frequent",
        "diseases": 7,
        "url": "https://dantelabs.com/genes/fgfr2"
      },
      {
        "slug": "flnb",
        "symbol": "FLNB",
        "hgnc": "HGNC:3755",
        "name": "filamin B",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/flnb"
      },
      {
        "slug": "gpc4",
        "symbol": "GPC4",
        "hgnc": "HGNC:4452",
        "name": "glypican 4",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/gpc4"
      },
      {
        "slug": "kcnh1",
        "symbol": "KCNH1",
        "hgnc": "HGNC:6250",
        "name": "potassium voltage-gated channel subfamily H member 1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/kcnh1"
      },
      {
        "slug": "map3k7",
        "symbol": "MAP3K7",
        "hgnc": "HGNC:6859",
        "name": "mitogen-activated protein kinase kinase kinase 7",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/map3k7"
      },
      {
        "slug": "nog",
        "symbol": "NOG",
        "hgnc": "HGNC:7866",
        "name": "noggin",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nog"
      },
      {
        "slug": "ppp2r3c",
        "symbol": "PPP2R3C",
        "hgnc": "HGNC:17485",
        "name": "protein phosphatase 2 regulatory subunit B''gamma",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ppp2r3c"
      },
      {
        "slug": "dvl1",
        "symbol": "DVL1",
        "hgnc": "HGNC:3084",
        "name": "dishevelled segment polarity protein 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/dvl1"
      },
      {
        "slug": "ezh2",
        "symbol": "EZH2",
        "hgnc": "HGNC:3527",
        "name": "enhancer of zeste 2 polycomb repressive complex 2 subunit",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ezh2"
      },
      {
        "slug": "fgf9",
        "symbol": "FGF9",
        "hgnc": "HGNC:3687",
        "name": "fibroblast growth factor 9",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/fgf9"
      },
      {
        "slug": "fgfr3",
        "symbol": "FGFR3",
        "hgnc": "HGNC:3690",
        "name": "fibroblast growth factor receptor 3",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/fgfr3"
      },
      {
        "slug": "gdf5",
        "symbol": "GDF5",
        "hgnc": "HGNC:4220",
        "name": "growth differentiation factor 5",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gdf5"
      },
      {
        "slug": "gdf6",
        "symbol": "GDF6",
        "hgnc": "HGNC:4221",
        "name": "growth differentiation factor 6",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gdf6"
      },
      {
        "slug": "gpc3",
        "symbol": "GPC3",
        "hgnc": "HGNC:4451",
        "name": "glypican 3",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gpc3"
      },
      {
        "slug": "hnrnpr",
        "symbol": "HNRNPR",
        "hgnc": "HGNC:5047",
        "name": "heterogeneous nuclear ribonucleoprotein R",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hnrnpr"
      },
      {
        "slug": "hpgd",
        "symbol": "HPGD",
        "hgnc": "HGNC:5154",
        "name": "15-hydroxyprostaglandin dehydrogenase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hpgd"
      },
      {
        "slug": "megf8",
        "symbol": "MEGF8",
        "hgnc": "HGNC:3233",
        "name": "multiple EGF like domains 8",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/megf8"
      },
      {
        "slug": "nsd1",
        "symbol": "NSD1",
        "hgnc": "HGNC:14234",
        "name": "nuclear receptor binding SET domain protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nsd1"
      },
      {
        "slug": "ofd1",
        "symbol": "OFD1",
        "hgnc": "HGNC:2567",
        "name": "OFD1 centriole and centriolar satellite protein",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ofd1"
      },
      {
        "slug": "otud6b",
        "symbol": "OTUD6B",
        "hgnc": "HGNC:24281",
        "name": "OTU deubiquitinase 6B",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/otud6b"
      },
      {
        "slug": "prkd1",
        "symbol": "PRKD1",
        "hgnc": "HGNC:9407",
        "name": "protein kinase D1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prkd1"
      },
      {
        "slug": "prkg2",
        "symbol": "PRKG2",
        "hgnc": "HGNC:9416",
        "name": "protein kinase cGMP-dependent 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prkg2"
      },
      {
        "slug": "rab23",
        "symbol": "RAB23",
        "hgnc": "HGNC:14263",
        "name": "RAB23, member RAS oncogene family",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rab23"
      },
      {
        "slug": "rbm8a",
        "symbol": "RBM8A",
        "hgnc": "HGNC:9905",
        "name": "RNA binding motif protein 8A",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/rbm8a"
      },
      {
        "slug": "ror2",
        "symbol": "ROR2",
        "hgnc": "HGNC:10257",
        "name": "ROR family WNT receptor 2",
        "frequency": "frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/ror2"
      },
      {
        "slug": "sall1",
        "symbol": "SALL1",
        "hgnc": "HGNC:10524",
        "name": "spalt like transcription factor 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/sall1"
      },
      {
        "slug": "satb2",
        "symbol": "SATB2",
        "hgnc": "HGNC:21637",
        "name": "SATB homeobox 2",
        "frequency": "frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/satb2"
      },
      {
        "slug": "siah1",
        "symbol": "SIAH1",
        "hgnc": "HGNC:10857",
        "name": "siah E3 ubiquitin protein ligase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/siah1"
      },
      {
        "slug": "smo",
        "symbol": "SMO",
        "hgnc": "HGNC:11119",
        "name": "smoothened, frizzled class receptor",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/smo"
      },
      {
        "slug": "srcap",
        "symbol": "SRCAP",
        "hgnc": "HGNC:16974",
        "name": "Snf2 related CREBBP activator protein",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/srcap"
      },
      {
        "slug": "sumf1",
        "symbol": "SUMF1",
        "hgnc": "HGNC:20376",
        "name": "sulfatase modifying factor 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/sumf1"
      },
      {
        "slug": "suz12",
        "symbol": "SUZ12",
        "hgnc": "HGNC:17101",
        "name": "SUZ12 polycomb repressive complex 2 subunit",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/suz12"
      },
      {
        "slug": "twist1",
        "symbol": "TWIST1",
        "hgnc": "HGNC:12428",
        "name": "twist family bHLH transcription factor 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/twist1"
      },
      {
        "slug": "usp9x",
        "symbol": "USP9X",
        "hgnc": "HGNC:12632",
        "name": "ubiquitin specific peptidase 9 X-linked",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/usp9x"
      },
      {
        "slug": "xylt1",
        "symbol": "XYLT1",
        "hgnc": "HGNC:15516",
        "name": "xylosyltransferase 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/xylt1"
      },
      {
        "slug": "znf668",
        "symbol": "ZNF668",
        "hgnc": "HGNC:25821",
        "name": "zinc finger protein 668",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/znf668"
      },
      {
        "slug": "bicra",
        "symbol": "BICRA",
        "hgnc": "HGNC:4332",
        "name": "BRD4 interacting chromatin remodeling complex associated protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bicra"
      },
      {
        "slug": "bmp2",
        "symbol": "BMP2",
        "hgnc": "HGNC:1069",
        "name": "bone morphogenetic protein 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bmp2"
      },
      {
        "slug": "bmpr1a",
        "symbol": "BMPR1A",
        "hgnc": "HGNC:1076",
        "name": "bone morphogenetic protein receptor type 1A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bmpr1a"
      },
      {
        "slug": "borcs8",
        "symbol": "BORCS8",
        "hgnc": "HGNC:37247",
        "name": "BLOC-1 related complex subunit 8",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/borcs8"
      },
      {
        "slug": "bptf",
        "symbol": "BPTF",
        "hgnc": "HGNC:3581",
        "name": "bromodomain PHD finger transcription factor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bptf"
      },
      {
        "slug": "cbfb",
        "symbol": "CBFB",
        "hgnc": "HGNC:1539",
        "name": "core-binding factor subunit beta",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cbfb"
      },
      {
        "slug": "dact1",
        "symbol": "DACT1",
        "hgnc": "HGNC:17748",
        "name": "dishevelled binding antagonist of beta catenin 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dact1"
      },
      {
        "slug": "dhx30",
        "symbol": "DHX30",
        "hgnc": "HGNC:16716",
        "name": "DExH-box helicase 30",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dhx30"
      },
      {
        "slug": "dvl3",
        "symbol": "DVL3",
        "hgnc": "HGNC:3087",
        "name": "dishevelled segment polarity protein 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dvl3"
      },
      {
        "slug": "gata4",
        "symbol": "GATA4",
        "hgnc": "HGNC:4173",
        "name": "GATA binding protein 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gata4"
      },
      {
        "slug": "h3-3a",
        "symbol": "H3-3A",
        "hgnc": "HGNC:4764",
        "name": "H3.3 histone A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/h3-3a"
      },
      {
        "slug": "ift56",
        "symbol": "IFT56",
        "hgnc": "HGNC:21882",
        "name": "intraflagellar transport 56",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ift56"
      },
      {
        "slug": "inppl1",
        "symbol": "INPPL1",
        "hgnc": "HGNC:6080",
        "name": "inositol polyphosphate phosphatase like 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/inppl1"
      },
      {
        "slug": "kctd1",
        "symbol": "KCTD1",
        "hgnc": "HGNC:18249",
        "name": "potassium channel tetramerization domain containing 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kctd1"
      },
      {
        "slug": "lmbr1",
        "symbol": "LMBR1",
        "hgnc": "HGNC:13243",
        "name": "limb development membrane protein 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmbr1"
      },
      {
        "slug": "man2c1",
        "symbol": "MAN2C1",
        "hgnc": "HGNC:6827",
        "name": "mannosidase alpha class 2C member 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/man2c1"
      },
      {
        "slug": "pacs1",
        "symbol": "PACS1",
        "hgnc": "HGNC:30032",
        "name": "phosphofurin acidic cluster sorting protein 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pacs1"
      },
      {
        "slug": "pcdhgc4",
        "symbol": "PCDHGC4",
        "hgnc": "HGNC:8717",
        "name": "protocadherin gamma subfamily C, 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pcdhgc4"
      },
      {
        "slug": "pigb",
        "symbol": "PIGB",
        "hgnc": "HGNC:8959",
        "name": "phosphatidylinositol glycan anchor biosynthesis class B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pigb"
      },
      {
        "slug": "pogz",
        "symbol": "POGZ",
        "hgnc": "HGNC:18801",
        "name": "pogo transposable element derived with ZNF domain",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pogz"
      },
      {
        "slug": "psmd12",
        "symbol": "PSMD12",
        "hgnc": "HGNC:9557",
        "name": "proteasome 26S subunit, non-ATPase 12",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/psmd12"
      },
      {
        "slug": "pten",
        "symbol": "PTEN",
        "hgnc": "HGNC:9588",
        "name": "phosphatase and tensin homolog",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pten"
      },
      {
        "slug": "puf60",
        "symbol": "PUF60",
        "hgnc": "HGNC:17042",
        "name": "poly(U) binding splicing factor 60",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/puf60"
      },
      {
        "slug": "pycr2",
        "symbol": "PYCR2",
        "hgnc": "HGNC:30262",
        "name": "pyrroline-5-carboxylate reductase 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pycr2"
      },
      {
        "slug": "rnu5b-1",
        "symbol": "RNU5B-1",
        "hgnc": "HGNC:10212",
        "name": "RNA, U5B small nuclear 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnu5b-1"
      },
      {
        "slug": "slc6a1",
        "symbol": "SLC6A1",
        "hgnc": "HGNC:11042",
        "name": "solute carrier family 6 member 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc6a1"
      },
      {
        "slug": "slc6a11",
        "symbol": "SLC6A11",
        "hgnc": "HGNC:11044",
        "name": "solute carrier family 6 member 11",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc6a11"
      },
      {
        "slug": "smoc1",
        "symbol": "SMOC1",
        "hgnc": "HGNC:20318",
        "name": "SPARC related modular calcium binding 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smoc1"
      },
      {
        "slug": "tbx5",
        "symbol": "TBX5",
        "hgnc": "HGNC:11604",
        "name": "T-box transcription factor 5",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbx5"
      },
      {
        "slug": "trpm3",
        "symbol": "TRPM3",
        "hgnc": "HGNC:17992",
        "name": "transient receptor potential cation channel subfamily M member 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trpm3"
      },
      {
        "slug": "adnp",
        "symbol": "ADNP",
        "hgnc": "HGNC:15766",
        "name": "activity dependent neuroprotector homeobox",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/adnp"
      },
      {
        "slug": "alx4",
        "symbol": "ALX4",
        "hgnc": "HGNC:450",
        "name": "ALX homeobox 4",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alx4"
      },
      {
        "slug": "gja5",
        "symbol": "GJA5",
        "hgnc": "HGNC:4279",
        "name": "gap junction protein alpha 5",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gja5"
      },
      {
        "slug": "gja8",
        "symbol": "GJA8",
        "hgnc": "HGNC:4281",
        "name": "gap junction protein alpha 8",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gja8"
      },
      {
        "slug": "msx2",
        "symbol": "MSX2",
        "hgnc": "HGNC:7392",
        "name": "msh homeobox 2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/msx2"
      },
      {
        "slug": "col2a1",
        "symbol": "COL2A1",
        "hgnc": "HGNC:2200",
        "name": "collagen type II alpha 1 chain",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col2a1"
      },
      {
        "slug": "eed",
        "symbol": "EED",
        "hgnc": "HGNC:3188",
        "name": "embryonic ectoderm development",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/eed"
      },
      {
        "slug": "g6pc3",
        "symbol": "G6PC3",
        "hgnc": "HGNC:24861",
        "name": "glucose-6-phosphatase catalytic subunit 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/g6pc3"
      },
      {
        "slug": "meis2",
        "symbol": "MEIS2",
        "hgnc": "HGNC:7001",
        "name": "Meis homeobox 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/meis2"
      },
      {
        "slug": "rlim",
        "symbol": "RLIM",
        "hgnc": "HGNC:13429",
        "name": "ring finger protein, LIM domain interacting",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rlim"
      },
      {
        "slug": "wnt5a",
        "symbol": "WNT5A",
        "hgnc": "HGNC:12784",
        "name": "Wnt family member 5A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wnt5a"
      }
    ]
  }
}