{
  "url": "https://dantelabs.com/traits/ankle-weakness",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "ankle-weakness",
    "id": "HP:0031374",
    "name": "Ankle weakness",
    "definition": "Reduced strength of the muscles that lift or otherwise move the foot at the ankle.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "muscle-weakness",
        "name": "Muscle weakness",
        "url": "https://dantelabs.com/traits/muscle-weakness"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "mpv17",
        "symbol": "MPV17",
        "hgnc": "HGNC:7224",
        "name": "mitochondrial inner membrane protein MPV17",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mpv17"
      },
      {
        "slug": "pmp22",
        "symbol": "PMP22",
        "hgnc": "HGNC:9118",
        "name": "peripheral myelin protein 22",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pmp22"
      },
      {
        "slug": "matr3",
        "symbol": "MATR3",
        "hgnc": "HGNC:6912",
        "name": "matrin 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/matr3"
      },
      {
        "slug": "ttn",
        "symbol": "TTN",
        "hgnc": "HGNC:12403",
        "name": "titin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ttn"
      },
      {
        "slug": "bscl2",
        "symbol": "BSCL2",
        "hgnc": "HGNC:15832",
        "name": "BSCL2 lipid droplet biogenesis associated, seipin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bscl2"
      },
      {
        "slug": "ldb3",
        "symbol": "LDB3",
        "hgnc": "HGNC:15710",
        "name": "LIM domain binding 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ldb3"
      }
    ]
  }
}