{
  "url": "https://dantelabs.com/traits/abnormal-factor-viii-activity",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-factor-viii-activity",
    "id": "HP:0030976",
    "name": "Abnormal factor VIII activity",
    "definition": "A deviation from the normal activity of coagulation factor VIII. Factor VIII (fVIII) is a cofactor in the intrinsic clotting cascade that is activated to fVIIIa in the presence of minute quantities of thrombin. fVIIIa acts as a receptor, for factors IXa and X.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-the-intrinsic-pathway",
        "name": "Abnormality of the intrinsic pathway",
        "url": "https://dantelabs.com/traits/abnormality-of-the-intrinsic-pathway"
      }
    ],
    "narrower": [
      {
        "slug": "reduced-factor-viii-activity",
        "name": "Reduced factor VIII activity",
        "genes": 6,
        "url": "https://dantelabs.com/traits/reduced-factor-viii-activity"
      },
      {
        "slug": "increased-factor-viii-activity",
        "name": "Increased factor VIII activity",
        "genes": 1,
        "url": "https://dantelabs.com/traits/increased-factor-viii-activity"
      }
    ],
    "genes": []
  }
}