{
  "url": "https://dantelabs.com/hu/genes/s1pr2",
  "gene": {
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    "symbol": "S1PR2",
    "name": "sphingosine-1-phosphate receptor 2",
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      "H218",
      "AGR16"
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      "DFNB68"
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    "entrezId": 9294,
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      "605111"
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      "release": "v1.5",
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      "ensemblTranscript": "ENST00000646641.1",
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      "ensemblProtein": "ENSP00000496438.1",
      "refseqProtein": "NP_004221.3",
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        {
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        {
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        {
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        {
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        {
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        {
          "symbol": "ZGLP1",
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        {
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        {
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        {
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        {
          "symbol": "RAVER1",
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        {
          "symbol": "ICAM3",
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        {
          "symbol": "TYK2",
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          "biotype": "protein_coding",
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        },
        {
          "symbol": "CDC37",
          "ensemblId": "ENSG00000105401",
          "biotype": "protein_coding",
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          "slug": "cdc37"
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        {
          "symbol": "PDE4A",
          "ensemblId": "ENSG00000065989",
          "biotype": "protein_coding",
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        {
          "symbol": "KEAP1",
          "ensemblId": "ENSG00000079999",
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        },
        {
          "symbol": "S1PR5",
          "ensemblId": "ENSG00000180739",
          "biotype": "protein_coding",
          "start": 10512742,
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          "strand": "-",
          "slug": "s1pr5"
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        {
          "symbol": "ATG4D",
          "ensemblId": "ENSG00000130734",
          "biotype": "protein_coding",
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        {
          "symbol": "KRI1",
          "ensemblId": "ENSG00000129347",
          "biotype": "protein_coding",
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          "slug": "kri1"
        },
        {
          "symbol": "CDKN2D",
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          "biotype": "protein_coding",
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          "strand": "-",
          "slug": "cdkn2d"
        },
        {
          "symbol": "AP1M2",
          "ensemblId": "ENSG00000129354",
          "biotype": "protein_coding",
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          "strand": "-",
          "slug": "ap1m2"
        },
        {
          "symbol": "SLC44A2",
          "ensemblId": "ENSG00000129353",
          "biotype": "protein_coding",
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        {
          "symbol": "ILF3",
          "ensemblId": "ENSG00000129351",
          "biotype": "protein_coding",
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          "strand": "+",
          "slug": "ilf3"
        },
        {
          "symbol": "QTRT1",
          "ensemblId": "ENSG00000213339",
          "biotype": "protein_coding",
          "start": 10701430,
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          "strand": "+",
          "slug": "qtrt1"
        },
        {
          "symbol": "DNM2",
          "ensemblId": "ENSG00000079805",
          "biotype": "protein_coding",
          "start": 10717967,
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          "strand": "+",
          "slug": "dnm2"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "hearing-loss-and-deafness",
        "name": "Hearing Loss and Deafness",
        "diseases": [
          {
            "mondoId": "MONDO:0019497",
            "name": "Nonsyndromic Genetic Hearing Loss",
            "genes": 97,
            "inheritance": null,
            "description": "Inherited hearing loss without other medical features, including the common recessive forms caused by GJB2, OTOF, SLC26A4, STRC and many other genes, as well as dominant, X-linked and mitochondrial forms.",
            "management": "Knowing the genetic cause can guide hearing support and cochlear implant decisions, gene-therapy trial eligibility (for example OTOF) and family counselling.",
            "evidence": {
              "gencc": [
                "ClinGen",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "clingen": "Strong",
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ],
              "actionability": 10
            },
            "sameAsReport": false,
            "broad": true
          }
        ],
        "url": "https://dantelabs.com/hu/conditions/hearing-loss-and-deafness"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "sensorineural-hearing-impairment",
        "name": "Sensorineural hearing impairment",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "url": "https://dantelabs.com/traits/sensorineural-hearing-impairment"
      }
    ],
    "related": [
      {
        "slug": "actg1",
        "symbol": "ACTG1",
        "name": "actin gamma 1",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/actg1"
      },
      {
        "slug": "afg2b",
        "symbol": "AFG2B",
        "name": "AAA ATPase AFG2B",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/afg2b"
      },
      {
        "slug": "aifm1",
        "symbol": "AIFM1",
        "name": "apoptosis inducing factor mitochondria associated 1",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/aifm1"
      },
      {
        "slug": "atp11a",
        "symbol": "ATP11A",
        "name": "ATPase phospholipid transporting 11A",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/atp11a"
      },
      {
        "slug": "atp2b2",
        "symbol": "ATP2B2",
        "name": "ATPase plasma membrane Ca2+ transporting 2",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/atp2b2"
      },
      {
        "slug": "cabp2",
        "symbol": "CABP2",
        "name": "calcium binding protein 2",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/cabp2"
      },
      {
        "slug": "cd164",
        "symbol": "CD164",
        "name": "CD164 molecule",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/cd164"
      },
      {
        "slug": "cdc14a",
        "symbol": "CDC14A",
        "name": "cell division cycle 14A",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/cdc14a"
      },
      {
        "slug": "cdh23",
        "symbol": "CDH23",
        "name": "cadherin related 23",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/cdh23"
      },
      {
        "slug": "ceacam16",
        "symbol": "CEACAM16",
        "name": "CEA cell adhesion molecule 16, tectorial membrane component",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/ceacam16"
      },
      {
        "slug": "cib2",
        "symbol": "CIB2",
        "name": "calcium and integrin binding family member 2",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/cib2"
      },
      {
        "slug": "cldn14",
        "symbol": "CLDN14",
        "name": "claudin 14",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/cldn14"
      }
    ],
    "sources": {
      "bundleId": "2026.10.16-c6eea6bf",
      "panel": "2026-10-16",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}