{
  "url": "https://dantelabs.com/hu/genes/mrps25",
  "gene": {
    "slug": "mrps25",
    "symbol": "MRPS25",
    "name": "mitochondrial ribosomal protein S25",
    "hgnc": "HGNC:14511",
    "summary": null,
    "location": "3p25.1",
    "locusType": "gene with protein product",
    "aliases": [
      "MRP-S25",
      "FLJ00023",
      "DKFZp313H0817",
      "RPMS25",
      "mS25"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000131368",
    "entrezId": 64432,
    "omim": [
      "611987"
    ],
    "uniprot": [
      "P82663"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "3",
      "start": 15048512,
      "end": 15065315,
      "strand": "-",
      "ensemblTranscript": "ENST00000253686.7",
      "refseqTranscript": "NM_022497.5",
      "ensemblProtein": "ENSP00000253686.2",
      "refseqProtein": "NP_071942.1",
      "exons": [
        {
          "start": 15048512,
          "end": 15052633
        },
        {
          "start": 15053380,
          "end": 15053467
        },
        {
          "start": 15059369,
          "end": 15059475
        },
        {
          "start": 15065061,
          "end": 15065315
        }
      ],
      "cds": {
        "start": 15052441,
        "end": 15065194
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "3",
      "start": 15083967,
      "end": 15106842,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 14556914,
      "end": 15556913,
      "genes": [
        {
          "symbol": "CCDC174",
          "ensemblId": "ENSG00000154781",
          "biotype": "protein_coding",
          "start": 14651746,
          "end": 14674940,
          "strand": "+",
          "slug": "ccdc174"
        },
        {
          "symbol": "FAM149C",
          "ensemblId": "ENSG00000131379",
          "biotype": "protein_coding",
          "start": 14675141,
          "end": 14773036,
          "strand": "+",
          "slug": "fam149c"
        },
        {
          "symbol": "FGD5",
          "ensemblId": "ENSG00000154783",
          "biotype": "protein_coding",
          "start": 14810505,
          "end": 14934571,
          "strand": "+",
          "slug": "fgd5"
        },
        {
          "symbol": "NR2C2",
          "ensemblId": "ENSG00000177463",
          "biotype": "protein_coding",
          "start": 14947324,
          "end": 15053600,
          "strand": "+",
          "slug": "nr2c2"
        },
        {
          "symbol": "RBSN",
          "ensemblId": "ENSG00000131381",
          "biotype": "protein_coding",
          "start": 15068565,
          "end": 15099163,
          "strand": "-",
          "slug": "rbsn"
        },
        {
          "symbol": "CAPN7",
          "ensemblId": "ENSG00000131375",
          "biotype": "protein_coding",
          "start": 15206112,
          "end": 15254068,
          "strand": "+",
          "slug": "capn7"
        },
        {
          "symbol": "SH3BP5",
          "ensemblId": "ENSG00000131370",
          "biotype": "protein_coding",
          "start": 15254254,
          "end": 15341368,
          "strand": "-",
          "slug": "sh3bp5"
        },
        {
          "symbol": "METTL6",
          "ensemblId": "ENSG00000206562",
          "biotype": "protein_coding",
          "start": 15381061,
          "end": 15440566,
          "strand": "-",
          "slug": "mettl6"
        },
        {
          "symbol": "EAF1",
          "ensemblId": "ENSG00000144597",
          "biotype": "protein_coding",
          "start": 15427552,
          "end": 15450635,
          "strand": "+",
          "slug": "eaf1"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000293553",
          "biotype": "protein_coding",
          "start": 15439199,
          "end": 15455940,
          "strand": "-"
        },
        {
          "symbol": "COLQ",
          "ensemblId": "ENSG00000206561",
          "biotype": "protein_coding",
          "start": 15450132,
          "end": 15521928,
          "strand": "-",
          "slug": "colq"
        },
        {
          "symbol": "HACL1",
          "ensemblId": "ENSG00000131373",
          "biotype": "protein_coding",
          "start": 15554790,
          "end": 15601883,
          "strand": "-",
          "slug": "hacl1"
        }
      ],
      "truncated": false
    },
    "reports": [],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "hip-dysplasia",
        "name": "Abnormal formation of the hip",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hip-dysplasia"
      },
      {
        "slug": "microcephaly",
        "name": "Abnormally small head",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/microcephaly"
      },
      {
        "slug": "adrenal-insufficiency",
        "name": "Adrenal insufficiency",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/adrenal-insufficiency"
      },
      {
        "slug": "brisk-reflexes",
        "name": "Brisk reflexes",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/brisk-reflexes"
      },
      {
        "slug": "decreased-activity-of-mitochondrial-complex-iv",
        "name": "Decreased activity of mitochondrial complex IV",
        "systems": [
          "abnormal-cellular-phenotype",
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/decreased-activity-of-mitochondrial-complex-iv"
      },
      {
        "slug": "delayed-ability-to-crawl",
        "name": "Delayed ability to crawl",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/delayed-ability-to-crawl"
      },
      {
        "slug": "delayed-ability-to-roll-over",
        "name": "Delayed ability to roll over",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/delayed-ability-to-roll-over"
      },
      {
        "slug": "delayed-ability-to-walk",
        "name": "Delayed ability to walk",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/delayed-ability-to-walk"
      },
      {
        "slug": "generalized-dystonia",
        "name": "Generalized dystonia",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/generalized-dystonia"
      },
      {
        "slug": "global-developmental-delay",
        "name": "Global developmental delay",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/global-developmental-delay"
      },
      {
        "slug": "motor-delay",
        "name": "Motor delay",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/motor-delay"
      },
      {
        "slug": "partial-agenesis-of-the-corpus-callosum",
        "name": "Partial agenesis of the corpus callosum",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/partial-agenesis-of-the-corpus-callosum"
      },
      {
        "slug": "poor-head-control",
        "name": "Poor head control",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/poor-head-control"
      },
      {
        "slug": "dysphagia",
        "name": "Poor swallowing",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/dysphagia"
      },
      {
        "slug": "intrauterine-growth-retardation",
        "name": "Prenatal growth deficiency",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/intrauterine-growth-retardation"
      },
      {
        "slug": "short-stature",
        "name": "Short stature",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/short-stature"
      }
    ],
    "related": [],
    "sources": null,
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}