{
  "url": "https://dantelabs.com/hu/genes/hrg",
  "gene": {
    "slug": "hrg",
    "symbol": "HRG",
    "name": "histidine rich glycoprotein",
    "hgnc": "HGNC:5181",
    "summary": null,
    "location": "3q27.3",
    "locusType": "gene with protein product",
    "aliases": [
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      "HPRG"
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    "previousSymbols": [],
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    "uniprot": [
      "P04196"
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      "release": "v1.5",
      "chrom": "3",
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      "ensemblTranscript": "ENST00000232003.5",
      "refseqTranscript": "NM_000412.5",
      "ensemblProtein": "ENSP00000232003.4",
      "refseqProtein": "NP_000403.1",
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    },
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      "build": "GRCh37",
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      "strand": "+"
    },
    "neighbourhood": {
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      "genes": [
        {
          "symbol": "DGKG",
          "ensemblId": "ENSG00000058866",
          "biotype": "protein_coding",
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          "slug": "dgkg"
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        {
          "symbol": "CRYGS",
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          "strand": "-",
          "slug": "crygs"
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        {
          "symbol": "TBCCD1",
          "ensemblId": "ENSG00000113838",
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          "slug": "tbccd1"
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        {
          "symbol": "DNAJB11",
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        {
          "symbol": "",
          "ensemblId": "ENSG00000283149",
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        {
          "symbol": "AHSG",
          "ensemblId": "ENSG00000145192",
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          "strand": "+",
          "slug": "ahsg"
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        {
          "symbol": "FETUB",
          "ensemblId": "ENSG00000090512",
          "biotype": "protein_coding",
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          "strand": "+",
          "slug": "fetub"
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        {
          "symbol": "KNG1",
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          "biotype": "protein_coding",
          "start": 186717329,
          "end": 186744736,
          "strand": "+",
          "slug": "kng1"
        },
        {
          "symbol": "EIF4A2",
          "ensemblId": "ENSG00000156976",
          "biotype": "protein_coding",
          "start": 186783205,
          "end": 186789901,
          "strand": "+",
          "slug": "eif4a2"
        },
        {
          "symbol": "RFC4",
          "ensemblId": "ENSG00000163918",
          "biotype": "protein_coding",
          "start": 186789866,
          "end": 186807058,
          "strand": "-",
          "slug": "rfc4"
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        {
          "symbol": "ADIPOQ",
          "ensemblId": "ENSG00000181092",
          "biotype": "protein_coding",
          "start": 186842674,
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          "strand": "+",
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        },
        {
          "symbol": "ST6GAL1",
          "ensemblId": "ENSG00000073849",
          "biotype": "protein_coding",
          "start": 186930325,
          "end": 187078932,
          "strand": "+",
          "slug": "st6gal1"
        },
        {
          "symbol": "RPL39L",
          "ensemblId": "ENSG00000163923",
          "biotype": "protein_coding",
          "start": 187120927,
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          "strand": "-",
          "slug": "rpl39l"
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      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "thrombophilia",
        "name": "Thrombophilia",
        "diseases": [
          {
            "mondoId": "MONDO:0100240",
            "name": "Inherited Thrombophilia",
            "genes": 9,
            "inheritance": null,
            "description": null,
            "management": "Anticoagulation (duration by genotype); avoid estrogen-containing contraceptives; LMWH for pregnancy prophylaxis; extended post-surgical anticoagulation; lifelong anticoagulation for compound/high-risk genotypes",
            "evidence": {
              "gencc": [
                "Genomics England PanelApp",
                "PanelApp Australia"
              ],
              "clingen": "Moderate",
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/hu/conditions/thrombophilia"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abnormal-thrombosis",
        "name": "Abnormal blood clot",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "url": "https://dantelabs.com/traits/abnormal-thrombosis"
      },
      {
        "slug": "decreased-level-of-histidine-rich-glycoprotein",
        "name": "Decreased level of histidine-rich glycoprotein",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/decreased-level-of-histidine-rich-glycoprotein"
      },
      {
        "slug": "hypercoagulability",
        "name": "Hypercoagulability",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "url": "https://dantelabs.com/traits/hypercoagulability"
      },
      {
        "slug": "recurrent-thromboembolism",
        "name": "Recurrent thromboembolism",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "url": "https://dantelabs.com/traits/recurrent-thromboembolism"
      }
    ],
    "related": [
      {
        "slug": "f2",
        "symbol": "F2",
        "name": "coagulation factor II, thrombin",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/f2"
      },
      {
        "slug": "f5",
        "symbol": "F5",
        "name": "coagulation factor V",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/f5"
      },
      {
        "slug": "f9",
        "symbol": "F9",
        "name": "coagulation factor IX",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/f9"
      },
      {
        "slug": "proc",
        "symbol": "PROC",
        "name": "protein C, inactivator of coagulation factors Va and VIIIa",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/proc"
      },
      {
        "slug": "pros1",
        "symbol": "PROS1",
        "name": "protein S",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/pros1"
      },
      {
        "slug": "serpinc1",
        "symbol": "SERPINC1",
        "name": "serpin family C member 1",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/serpinc1"
      },
      {
        "slug": "serpind1",
        "symbol": "SERPIND1",
        "name": "serpin family D member 1",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/serpind1"
      },
      {
        "slug": "thbd",
        "symbol": "THBD",
        "name": "thrombomodulin",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/thbd"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}