{
  "url": "https://dantelabs.com/hu/genes/grxcr2",
  "gene": {
    "slug": "grxcr2",
    "symbol": "GRXCR2",
    "name": "glutaredoxin and cysteine rich domain containing 2",
    "hgnc": "HGNC:33862",
    "summary": null,
    "location": "5q32",
    "locusType": "gene with protein product",
    "aliases": [
      "DFNB101"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000204928",
    "entrezId": 643226,
    "omim": [
      "615762"
    ],
    "uniprot": [
      "A6NFK2"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "5",
      "start": 145858521,
      "end": 145873014,
      "strand": "-",
      "ensemblTranscript": "ENST00000377976.3",
      "refseqTranscript": "NM_001080516.2",
      "ensemblProtein": "ENSP00000367214.1",
      "refseqProtein": "NP_001073985.1",
      "exons": [
        {
          "start": 145858521,
          "end": 145859915
        },
        {
          "start": 145866501,
          "end": 145866728
        },
        {
          "start": 145872633,
          "end": 145873014
        }
      ],
      "cds": {
        "start": 145859733,
        "end": 145872968
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "5",
      "start": 145239296,
      "end": 145252531,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 145365768,
      "end": 146365767,
      "genes": [
        {
          "symbol": "PRELID2",
          "ensemblId": "ENSG00000186314",
          "biotype": "protein_coding",
          "start": 145471799,
          "end": 145835379,
          "strand": "-",
          "slug": "prelid2"
        },
        {
          "symbol": "SH3RF2",
          "ensemblId": "ENSG00000156463",
          "biotype": "protein_coding",
          "start": 145936425,
          "end": 146085976,
          "strand": "+",
          "slug": "sh3rf2"
        },
        {
          "symbol": "PLAC8L1",
          "ensemblId": "ENSG00000173261",
          "biotype": "protein_coding",
          "start": 146084313,
          "end": 146106205,
          "strand": "-",
          "slug": "plac8l1"
        },
        {
          "symbol": "LARS1",
          "ensemblId": "ENSG00000133706",
          "biotype": "protein_coding",
          "start": 146110566,
          "end": 146182696,
          "strand": "-",
          "slug": "lars1"
        },
        {
          "symbol": "RBM27",
          "ensemblId": "ENSG00000091009",
          "biotype": "protein_coding",
          "start": 146203550,
          "end": 146289462,
          "strand": "+",
          "slug": "rbm27"
        },
        {
          "symbol": "RBM27-POU4F3",
          "ensemblId": "ENSG00000275740",
          "biotype": "protein_coding",
          "start": 146203550,
          "end": 146339251,
          "strand": "+",
          "slug": "rbm27-pou4f3"
        },
        {
          "symbol": "POU4F3",
          "ensemblId": "ENSG00000091010",
          "biotype": "protein_coding",
          "start": 146338648,
          "end": 146341728,
          "strand": "+",
          "slug": "pou4f3"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "hearing-loss-and-deafness",
        "name": "Hearing Loss and Deafness",
        "diseases": [
          {
            "mondoId": "MONDO:0019497",
            "name": "Nonsyndromic Genetic Hearing Loss",
            "genes": 97,
            "inheritance": null,
            "description": "Inherited hearing loss without other medical features, including the common recessive forms caused by GJB2, OTOF, SLC26A4, STRC and many other genes, as well as dominant, X-linked and mitochondrial forms.",
            "management": "Knowing the genetic cause can guide hearing support and cochlear implant decisions, gene-therapy trial eligibility (for example OTOF) and family counselling.",
            "evidence": {
              "gencc": [
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "clingen": "Moderate",
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": false,
            "broad": true
          }
        ],
        "url": "https://dantelabs.com/hu/conditions/hearing-loss-and-deafness"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "bilateral-sensorineural-hearing-impairment",
        "name": "Bilateral sensorineural hearing impairment",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/bilateral-sensorineural-hearing-impairment"
      }
    ],
    "related": [
      {
        "slug": "actg1",
        "symbol": "ACTG1",
        "name": "actin gamma 1",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/actg1"
      },
      {
        "slug": "afg2b",
        "symbol": "AFG2B",
        "name": "AAA ATPase AFG2B",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/afg2b"
      },
      {
        "slug": "aifm1",
        "symbol": "AIFM1",
        "name": "apoptosis inducing factor mitochondria associated 1",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/aifm1"
      },
      {
        "slug": "atp11a",
        "symbol": "ATP11A",
        "name": "ATPase phospholipid transporting 11A",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/atp11a"
      },
      {
        "slug": "atp2b2",
        "symbol": "ATP2B2",
        "name": "ATPase plasma membrane Ca2+ transporting 2",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/atp2b2"
      },
      {
        "slug": "cabp2",
        "symbol": "CABP2",
        "name": "calcium binding protein 2",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/cabp2"
      },
      {
        "slug": "cd164",
        "symbol": "CD164",
        "name": "CD164 molecule",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/cd164"
      },
      {
        "slug": "cdc14a",
        "symbol": "CDC14A",
        "name": "cell division cycle 14A",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/cdc14a"
      },
      {
        "slug": "cdh23",
        "symbol": "CDH23",
        "name": "cadherin related 23",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/cdh23"
      },
      {
        "slug": "ceacam16",
        "symbol": "CEACAM16",
        "name": "CEA cell adhesion molecule 16, tectorial membrane component",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/ceacam16"
      },
      {
        "slug": "cib2",
        "symbol": "CIB2",
        "name": "calcium and integrin binding family member 2",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/cib2"
      },
      {
        "slug": "cldn14",
        "symbol": "CLDN14",
        "name": "claudin 14",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/cldn14"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}