{
  "url": "https://dantelabs.com/hu/genes/gpr161",
  "gene": {
    "slug": "gpr161",
    "symbol": "GPR161",
    "name": "G protein-coupled receptor 161",
    "hgnc": "HGNC:23694",
    "summary": null,
    "location": "1q24.2",
    "locusType": "gene with protein product",
    "aliases": [
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    "previousSymbols": [],
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      "release": "v1.5",
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      "ensemblTranscript": "ENST00000682931.1",
      "refseqTranscript": "NM_001375883.1",
      "ensemblProtein": "ENSP00000506967.1",
      "refseqProtein": "NP_001362812.1",
      "exons": [
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    },
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      "build": "GRCh37",
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    "neighbourhood": {
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        {
          "symbol": "RCSD1",
          "ensemblId": "ENSG00000198771",
          "biotype": "protein_coding",
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          "end": 167708706,
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        {
          "symbol": "MPZL1",
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          "end": 167794612,
          "strand": "+",
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        {
          "symbol": "ADCY10",
          "ensemblId": "ENSG00000143199",
          "biotype": "protein_coding",
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        },
        {
          "symbol": "MPC2",
          "ensemblId": "ENSG00000143158",
          "biotype": "protein_coding",
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        {
          "symbol": "DCAF6",
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          "strand": "+",
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        },
        {
          "symbol": "TIPRL",
          "ensemblId": "ENSG00000143155",
          "biotype": "protein_coding",
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          "strand": "+",
          "slug": "tiprl"
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        {
          "symbol": "SFT2D2",
          "ensemblId": "ENSG00000213064",
          "biotype": "protein_coding",
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          "end": 168263172,
          "strand": "+",
          "slug": "sft2d2"
        },
        {
          "symbol": "TBX19",
          "ensemblId": "ENSG00000143178",
          "biotype": "protein_coding",
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          "end": 168314426,
          "strand": "+",
          "slug": "tbx19"
        },
        {
          "symbol": "XCL2",
          "ensemblId": "ENSG00000143185",
          "biotype": "protein_coding",
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          "end": 168544113,
          "strand": "-",
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        },
        {
          "symbol": "XCL1",
          "ensemblId": "ENSG00000143184",
          "biotype": "protein_coding",
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          "strand": "+",
          "slug": "xcl1"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "medulloblastoma",
        "name": "Medulloblastoma",
        "diseases": [
          {
            "mondoId": "MONDO:1010204",
            "name": "GPR161-related medulloblastoma predisposition",
            "genes": 1,
            "inheritance": "autosomal-dominant",
            "description": "GPR161 variants that predispose to sonic hedgehog-type medulloblastoma in early childhood.",
            "management": "Awareness of neurological symptoms in young children and consideration of brain MRI surveillance.",
            "evidence": {
              "gencc": [
                "ClinGen"
              ],
              "clingen": "Strong",
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": false,
            "broad": false
          },
          {
            "mondoId": "MONDO:0007959",
            "name": "medulloblastoma",
            "genes": 3,
            "inheritance": "autosomal-dominant",
            "description": null,
            "management": null,
            "evidence": {
              "gencc": [
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": true,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/hu/conditions/medulloblastoma"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abnormality-of-the-hypothalamus-pituitary-axis",
        "name": "Abnormality of the hypothalamus-pituitary axis",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormality-of-the-hypothalamus-pituitary-axis"
      },
      {
        "slug": "delayed-puberty",
        "name": "Delayed puberty",
        "systems": [
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          "growth-abnormality"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/delayed-puberty"
      },
      {
        "slug": "diabetes-insipidus",
        "name": "Diabetes insipidus",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/diabetes-insipidus"
      },
      {
        "slug": "ectopic-posterior-pituitary",
        "name": "Ectopic posterior pituitary",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/ectopic-posterior-pituitary"
      },
      {
        "slug": "seizure",
        "name": "Epilepsy",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/seizure"
      },
      {
        "slug": "failure-to-thrive",
        "name": "Faltering weight",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/failure-to-thrive"
      },
      {
        "slug": "global-developmental-delay",
        "name": "Global developmental delay",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/global-developmental-delay"
      },
      {
        "slug": "intellectual-disability",
        "name": "Intellectual disability",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/intellectual-disability"
      },
      {
        "slug": "hypoglycemia",
        "name": "Low blood sugar",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hypoglycemia"
      },
      {
        "slug": "medulloblastoma",
        "name": "Medulloblastoma",
        "systems": [
          "abnormality-of-the-nervous-system",
          "neoplasm"
        ],
        "url": "https://dantelabs.com/traits/medulloblastoma"
      },
      {
        "slug": "primary-amenorrhea",
        "name": "Primary amenorrhea",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/primary-amenorrhea"
      },
      {
        "slug": "septo-optic-dysplasia",
        "name": "Septo-optic dysplasia",
        "systems": [
          "abnormality-of-the-eye",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/septo-optic-dysplasia"
      },
      {
        "slug": "short-stature",
        "name": "Short stature",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/short-stature"
      },
      {
        "slug": "adrenal-hypoplasia",
        "name": "Small adrenal glands",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/adrenal-hypoplasia"
      },
      {
        "slug": "hypothyroidism",
        "name": "Underactive thyroid",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hypothyroidism"
      },
      {
        "slug": "hypoplasia-of-penis",
        "name": "Underdeveloped penis",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hypoplasia-of-penis"
      },
      {
        "slug": "cryptorchidism",
        "name": "Undescended testes",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/cryptorchidism"
      }
    ],
    "related": [
      {
        "slug": "elp1",
        "symbol": "ELP1",
        "name": "elongator acetyltransferase complex subunit 1",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/elp1"
      },
      {
        "slug": "sufu",
        "symbol": "SUFU",
        "name": "SUFU negative regulator of hedgehog signaling",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/sufu"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}