{
  "url": "https://dantelabs.com/hu/genes/gnrhr",
  "gene": {
    "slug": "gnrhr",
    "symbol": "GNRHR",
    "name": "gonadotropin releasing hormone receptor",
    "hgnc": "HGNC:4421",
    "summary": null,
    "location": "4q13.2",
    "locusType": "gene with protein product",
    "aliases": [
      "LHRHR"
    ],
    "previousSymbols": [
      "GRHR"
    ],
    "ensemblId": "ENSG00000109163",
    "entrezId": 2798,
    "omim": [
      "138850"
    ],
    "uniprot": [
      "P30968"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "4",
      "start": 67737118,
      "end": 67754388,
      "strand": "-",
      "ensemblTranscript": "ENST00000226413.5",
      "refseqTranscript": "NM_000406.3",
      "ensemblProtein": "ENSP00000226413.5",
      "refseqProtein": "NP_000397.1",
      "exons": [
        {
          "start": 67737118,
          "end": 67740724
        },
        {
          "start": 67744568,
          "end": 67744787
        },
        {
          "start": 67753814,
          "end": 67754388
        }
      ],
      "cds": {
        "start": 67740480,
        "end": 67754335
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "4",
      "start": 68605046,
      "end": 68620078,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 67245753,
      "end": 68245752,
      "genes": [
        {
          "symbol": "CENPC",
          "ensemblId": "ENSG00000145241",
          "biotype": "protein_coding",
          "start": 67468762,
          "end": 67545565,
          "strand": "-",
          "slug": "cenpc"
        },
        {
          "symbol": "STAP1",
          "ensemblId": "ENSG00000035720",
          "biotype": "protein_coding",
          "start": 67558482,
          "end": 67607343,
          "strand": "+",
          "slug": "stap1"
        },
        {
          "symbol": "UBA6",
          "ensemblId": "ENSG00000033178",
          "biotype": "protein_coding",
          "start": 67610428,
          "end": 67701338,
          "strand": "-",
          "slug": "uba6"
        },
        {
          "symbol": "TMPRSS11D",
          "ensemblId": "ENSG00000153802",
          "biotype": "protein_coding",
          "start": 67820876,
          "end": 67884002,
          "strand": "-",
          "slug": "tmprss11d"
        },
        {
          "symbol": "TMPRSS11A",
          "ensemblId": "ENSG00000187054",
          "biotype": "protein_coding",
          "start": 67909395,
          "end": 67964140,
          "strand": "-",
          "slug": "tmprss11a"
        },
        {
          "symbol": "TMPRSS11F",
          "ensemblId": "ENSG00000198092",
          "biotype": "protein_coding",
          "start": 68053198,
          "end": 68129869,
          "strand": "-",
          "slug": "tmprss11f"
        },
        {
          "symbol": "TMPRSS11B",
          "ensemblId": "ENSG00000185873",
          "biotype": "protein_coding",
          "start": 68226653,
          "end": 68245694,
          "strand": "-",
          "slug": "tmprss11b"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "hypogonadotropic-hypogonadism",
        "name": "Hypogonadotropic Hypogonadism",
        "diseases": [
          {
            "mondoId": "MONDO:0018555",
            "name": "Hypogonadotropic Hypogonadism",
            "genes": 49,
            "inheritance": null,
            "description": "Abnormal ovarian or testicular function due to insufficient hormonal stimulation from the hypothalamic-pituitary axis.",
            "management": null,
            "evidence": {
              "gencc": [
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": true,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/hu/conditions/hypogonadotropic-hypogonadism"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abnormality-of-the-dentition",
        "name": "Abnormal dentition",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormality-of-the-dentition"
      },
      {
        "slug": "abnormality-of-body-height",
        "name": "Abnormality of body height",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormality-of-body-height"
      },
      {
        "slug": "abnormality-of-the-voice",
        "name": "Abnormality of the voice",
        "systems": [],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormality-of-the-voice"
      },
      {
        "slug": "absence-of-pubertal-development",
        "name": "Absence of pubertal development",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/absence-of-pubertal-development"
      },
      {
        "slug": "absence-of-secondary-sex-characteristics",
        "name": "Absence of secondary sex characteristics",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/absence-of-secondary-sex-characteristics"
      },
      {
        "slug": "azoospermia",
        "name": "Absent sperm in semen",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/azoospermia"
      },
      {
        "slug": "anxiety",
        "name": "Anxiety",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/anxiety"
      },
      {
        "slug": "cleft-palate",
        "name": "Cleft palate",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/cleft-palate"
      },
      {
        "slug": "congenital-sensorineural-hearing-impairment",
        "name": "Congenital sensorineural hearing impairment",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/congenital-sensorineural-hearing-impairment"
      },
      {
        "slug": "male-hypogonadism",
        "name": "Decreased function of male gonad",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/male-hypogonadism"
      },
      {
        "slug": "decreased-serum-testosterone-concentration",
        "name": "Decreased serum testosterone level",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/decreased-serum-testosterone-concentration"
      },
      {
        "slug": "decreased-testicular-size",
        "name": "Decreased testicular size",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/decreased-testicular-size"
      },
      {
        "slug": "delayed-skeletal-maturation",
        "name": "Delayed bone maturation",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/delayed-skeletal-maturation"
      },
      {
        "slug": "delayed-puberty",
        "name": "Delayed puberty",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "growth-abnormality"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/delayed-puberty"
      },
      {
        "slug": "depressed-nasal-bridge",
        "name": "Depressed nasal bridge",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/depressed-nasal-bridge"
      },
      {
        "slug": "depression",
        "name": "Depression",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/depression"
      },
      {
        "slug": "impotence",
        "name": "Difficulty getting a full erection",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/impotence"
      },
      {
        "slug": "gynecomastia",
        "name": "Enlarged male breast",
        "systems": [
          "abnormality-of-the-breast"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/gynecomastia"
      },
      {
        "slug": "eunuchoid-habitus",
        "name": "Eunuchoid habitus",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/eunuchoid-habitus"
      },
      {
        "slug": "female-hypogonadism",
        "name": "Female hypogonadism",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/female-hypogonadism"
      },
      {
        "slug": "generalized-joint-hypermobility",
        "name": "Hypermobility of all joints",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/generalized-joint-hypermobility"
      },
      {
        "slug": "hypogonadotropic-hypogonadism",
        "name": "Hypogonadotropic hypogonadism",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hypogonadotropic-hypogonadism"
      },
      {
        "slug": "increased-female-libido",
        "name": "Increased female sex drive",
        "systems": [
          "abnormality-of-the-genitourinary-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/increased-female-libido"
      },
      {
        "slug": "infertility",
        "name": "Infertility",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/infertility"
      },
      {
        "slug": "sparse-axillary-hair",
        "name": "Limited armpit hair",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/sparse-axillary-hair"
      },
      {
        "slug": "non-obstructive-azoospermia",
        "name": "Non-obstructive azoospermia",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/non-obstructive-azoospermia"
      },
      {
        "slug": "osteopenia",
        "name": "Osteopenia",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/osteopenia"
      },
      {
        "slug": "osteoporosis",
        "name": "Osteoporosis",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/osteoporosis"
      },
      {
        "slug": "camptodactyly",
        "name": "Permanent flexion of the finger or toe",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/camptodactyly"
      },
      {
        "slug": "secondary-amenorrhea",
        "name": "Previous menstrual periods stop",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/secondary-amenorrhea"
      },
      {
        "slug": "primary-amenorrhea",
        "name": "Primary amenorrhea",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/primary-amenorrhea"
      },
      {
        "slug": "micropenis",
        "name": "Short penis",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/micropenis"
      },
      {
        "slug": "hypoplasia-of-the-uterus",
        "name": "Small uterus",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hypoplasia-of-the-uterus"
      },
      {
        "slug": "sparse-body-hair",
        "name": "Sparse body hair",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/sparse-body-hair"
      },
      {
        "slug": "sparse-pubic-hair",
        "name": "Sparse pubic hair",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/sparse-pubic-hair"
      },
      {
        "slug": "breast-hypoplasia",
        "name": "Underdeveloped breasts",
        "systems": [
          "abnormality-of-the-breast"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/breast-hypoplasia"
      },
      {
        "slug": "hypoplasia-of-the-ovary",
        "name": "Underdeveloped ovary",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hypoplasia-of-the-ovary"
      },
      {
        "slug": "cryptorchidism",
        "name": "Undescended testes",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/cryptorchidism"
      },
      {
        "slug": "hypertelorism",
        "name": "Wide-set eyes",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hypertelorism"
      },
      {
        "slug": "wide-intermamillary-distance",
        "name": "Wide-spaced nipples",
        "systems": [
          "abnormality-of-the-breast"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/wide-intermamillary-distance"
      }
    ],
    "related": [
      {
        "slug": "anos1",
        "symbol": "ANOS1",
        "name": "anosmin 1",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/anos1"
      },
      {
        "slug": "arhgap35",
        "symbol": "ARHGAP35",
        "name": "Rho GTPase activating protein 35",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/arhgap35"
      },
      {
        "slug": "chd7",
        "symbol": "CHD7",
        "name": "chromodomain helicase DNA binding protein 7",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/chd7"
      },
      {
        "slug": "cpe",
        "symbol": "CPE",
        "name": "carboxypeptidase E",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/cpe"
      },
      {
        "slug": "dcaf17",
        "symbol": "DCAF17",
        "name": "DDB1 and CUL4 associated factor 17",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/dcaf17"
      },
      {
        "slug": "fezf1",
        "symbol": "FEZF1",
        "name": "FEZ family zinc finger 1",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/fezf1"
      },
      {
        "slug": "fgf17",
        "symbol": "FGF17",
        "name": "fibroblast growth factor 17",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/fgf17"
      },
      {
        "slug": "fgf8",
        "symbol": "FGF8",
        "name": "fibroblast growth factor 8",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/fgf8"
      },
      {
        "slug": "fgfr1",
        "symbol": "FGFR1",
        "name": "fibroblast growth factor receptor 1",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/fgfr1"
      },
      {
        "slug": "foxa2",
        "symbol": "FOXA2",
        "name": "forkhead box A2",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/foxa2"
      },
      {
        "slug": "fshb",
        "symbol": "FSHB",
        "name": "follicle stimulating hormone subunit beta",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/fshb"
      },
      {
        "slug": "gh1",
        "symbol": "GH1",
        "name": "growth hormone 1",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/gh1"
      }
    ],
    "sources": {
      "bundleId": "2026.10.19-9814e911",
      "panel": "2026-10-19",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}