{
  "url": "https://dantelabs.com/hu/genes/glis2",
  "gene": {
    "slug": "glis2",
    "symbol": "GLIS2",
    "name": "GLIS family zinc finger 2",
    "hgnc": "HGNC:29450",
    "summary": null,
    "location": "16p13.3",
    "locusType": "gene with protein product",
    "aliases": [
      "NPHP7"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000126603",
    "entrezId": 84662,
    "omim": [
      "608539"
    ],
    "uniprot": [
      "Q9BZE0"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "16",
      "start": 4316067,
      "end": 4339595,
      "strand": "+",
      "ensemblTranscript": "ENST00000433375.2",
      "refseqTranscript": "NM_032575.3",
      "ensemblProtein": "ENSP00000395547.1",
      "refseqProtein": "NP_115964.2",
      "exons": [
        {
          "start": 4316067,
          "end": 4316254
        },
        {
          "start": 4332215,
          "end": 4332452
        },
        {
          "start": 4333347,
          "end": 4333519
        },
        {
          "start": 4334801,
          "end": 4334977
        },
        {
          "start": 4335060,
          "end": 4335193
        },
        {
          "start": 4335275,
          "end": 4335393
        },
        {
          "start": 4336725,
          "end": 4339595
        }
      ],
      "cds": {
        "start": 4332281,
        "end": 4337524
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "16",
      "start": 4364762,
      "end": 4389598,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
      "start": 3827831,
      "end": 4827830,
      "genes": [
        {
          "symbol": "CREBBP",
          "ensemblId": "ENSG00000005339",
          "biotype": "protein_coding",
          "start": 3725054,
          "end": 3880734,
          "strand": "-",
          "slug": "crebbp"
        },
        {
          "symbol": "ADCY9",
          "ensemblId": "ENSG00000162104",
          "biotype": "protein_coding",
          "start": 3953387,
          "end": 4116493,
          "strand": "-",
          "slug": "adcy9"
        },
        {
          "symbol": "SRL",
          "ensemblId": "ENSG00000185739",
          "biotype": "protein_coding",
          "start": 4189369,
          "end": 4242283,
          "strand": "-",
          "slug": "srl"
        },
        {
          "symbol": "TFAP4",
          "ensemblId": "ENSG00000090447",
          "biotype": "protein_coding",
          "start": 4257186,
          "end": 4273075,
          "strand": "-",
          "slug": "tfap4"
        },
        {
          "symbol": "PAM16",
          "ensemblId": "ENSG00000217930",
          "biotype": "protein_coding",
          "start": 4330378,
          "end": 4355607,
          "strand": "-",
          "slug": "pam16"
        },
        {
          "symbol": "CORO7-PAM16",
          "ensemblId": "ENSG00000103426",
          "biotype": "protein_coding",
          "start": 4340251,
          "end": 4420494,
          "strand": "-",
          "slug": "coro7-pam16"
        },
        {
          "symbol": "CORO7",
          "ensemblId": "ENSG00000262246",
          "biotype": "protein_coding",
          "start": 4354542,
          "end": 4425705,
          "strand": "-",
          "slug": "coro7"
        },
        {
          "symbol": "VASN",
          "ensemblId": "ENSG00000168140",
          "biotype": "protein_coding",
          "start": 4371841,
          "end": 4383538,
          "strand": "+",
          "slug": "vasn"
        },
        {
          "symbol": "DNAJA3",
          "ensemblId": "ENSG00000103423",
          "biotype": "protein_coding",
          "start": 4425805,
          "end": 4460593,
          "strand": "+",
          "slug": "dnaja3"
        },
        {
          "symbol": "NMRAL1",
          "ensemblId": "ENSG00000153406",
          "biotype": "protein_coding",
          "start": 4461673,
          "end": 4495763,
          "strand": "-",
          "slug": "nmral1"
        },
        {
          "symbol": "HMOX2",
          "ensemblId": "ENSG00000103415",
          "biotype": "protein_coding",
          "start": 4474246,
          "end": 4510663,
          "strand": "+",
          "slug": "hmox2"
        },
        {
          "symbol": "CDIP1",
          "ensemblId": "ENSG00000089486",
          "biotype": "protein_coding",
          "start": 4510619,
          "end": 4538833,
          "strand": "-",
          "slug": "cdip1"
        },
        {
          "symbol": "C16orf96",
          "ensemblId": "ENSG00000205832",
          "biotype": "protein_coding",
          "start": 4556336,
          "end": 4600772,
          "strand": "+",
          "slug": "c16orf96"
        },
        {
          "symbol": "UBALD1",
          "ensemblId": "ENSG00000153443",
          "biotype": "protein_coding",
          "start": 4608879,
          "end": 4615046,
          "strand": "-",
          "slug": "ubald1"
        },
        {
          "symbol": "MGRN1",
          "ensemblId": "ENSG00000102858",
          "biotype": "protein_coding",
          "start": 4616493,
          "end": 4690977,
          "strand": "+",
          "slug": "mgrn1"
        },
        {
          "symbol": "NUDT16L1",
          "ensemblId": "ENSG00000168101",
          "biotype": "protein_coding",
          "start": 4693562,
          "end": 4695861,
          "strand": "+",
          "slug": "nudt16l1"
        },
        {
          "symbol": "ANKS3",
          "ensemblId": "ENSG00000168096",
          "biotype": "protein_coding",
          "start": 4696500,
          "end": 4734388,
          "strand": "-",
          "slug": "anks3"
        },
        {
          "symbol": "DNAAF8",
          "ensemblId": "ENSG00000166246",
          "biotype": "protein_coding",
          "start": 4734315,
          "end": 4749396,
          "strand": "+",
          "slug": "dnaaf8"
        },
        {
          "symbol": "ZNF500",
          "ensemblId": "ENSG00000103199",
          "biotype": "protein_coding",
          "start": 4748239,
          "end": 4767624,
          "strand": "-",
          "slug": "znf500"
        },
        {
          "symbol": "SEPTIN12",
          "ensemblId": "ENSG00000140623",
          "biotype": "protein_coding",
          "start": 4777606,
          "end": 4788398,
          "strand": "-",
          "slug": "septin12"
        },
        {
          "symbol": "SMIM22",
          "ensemblId": "ENSG00000267795",
          "biotype": "protein_coding",
          "start": 4788376,
          "end": 4796731,
          "strand": "+",
          "slug": "smim22"
        },
        {
          "symbol": "ROGDI",
          "ensemblId": "ENSG00000067836",
          "biotype": "protein_coding",
          "start": 4796962,
          "end": 4802926,
          "strand": "-",
          "slug": "rogdi"
        },
        {
          "symbol": "GLYR1",
          "ensemblId": "ENSG00000140632",
          "biotype": "protein_coding",
          "start": 4803202,
          "end": 4847343,
          "strand": "-",
          "slug": "glyr1"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "nephronophthisis-senior-loken-syndrome",
        "name": "Nephronophthisis and Senior-Løken Syndrome",
        "diseases": [
          {
            "mondoId": "MONDO:0019005",
            "name": "Nephronophthisis",
            "genes": 17,
            "inheritance": "autosomal-recessive",
            "description": "A recessively inherited kidney disease, caused by variants in NPHP1 and other cilia genes, in which progressive tubulointerstitial scarring leads to kidney failure, typically in the first three decades of life.",
            "management": "Knowing allows regular kidney function monitoring, timely planning for dialysis or transplantation, and carrier testing for relatives.",
            "evidence": {
              "gencc": [
                "G2P",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "clingen": "Moderate",
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/hu/conditions/nephronophthisis-senior-loken-syndrome"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "nephronophthisis",
        "name": "Nephronophthisis",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/nephronophthisis"
      },
      {
        "slug": "renal-tubular-atrophy",
        "name": "Renal tubular atrophy",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/renal-tubular-atrophy"
      },
      {
        "slug": "stage-5-chronic-kidney-disease",
        "name": "Stage 5 chronic kidney disease",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/stage-5-chronic-kidney-disease"
      }
    ],
    "related": [
      {
        "slug": "adamts9",
        "symbol": "ADAMTS9",
        "name": "ADAM metallopeptidase with thrombospondin type 1 motif 9",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/adamts9"
      },
      {
        "slug": "anks6",
        "symbol": "ANKS6",
        "name": "ankyrin repeat and sterile alpha motif domain containing 6",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/anks6"
      },
      {
        "slug": "cep164",
        "symbol": "CEP164",
        "name": "centrosomal protein 164",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/cep164"
      },
      {
        "slug": "cep83",
        "symbol": "CEP83",
        "name": "centrosomal protein 83",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/cep83"
      },
      {
        "slug": "dcdc2",
        "symbol": "DCDC2",
        "name": "doublecortin domain containing 2",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/dcdc2"
      },
      {
        "slug": "invs",
        "symbol": "INVS",
        "name": "inversin",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/invs"
      },
      {
        "slug": "mapkbp1",
        "symbol": "MAPKBP1",
        "name": "mitogen-activated protein kinase binding protein 1",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/mapkbp1"
      },
      {
        "slug": "nek8",
        "symbol": "NEK8",
        "name": "NIMA related kinase 8",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/nek8"
      },
      {
        "slug": "nphp1",
        "symbol": "NPHP1",
        "name": "nephrocystin 1",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/nphp1"
      },
      {
        "slug": "nphp3",
        "symbol": "NPHP3",
        "name": "nephrocystin 3",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/nphp3"
      },
      {
        "slug": "nphp4",
        "symbol": "NPHP4",
        "name": "nephrocystin 4",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/nphp4"
      },
      {
        "slug": "tmem67",
        "symbol": "TMEM67",
        "name": "transmembrane protein 67",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/tmem67"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}