{
  "url": "https://dantelabs.com/hu/genes/f13a1",
  "gene": {
    "slug": "f13a1",
    "symbol": "F13A1",
    "name": "coagulation factor XIII A chain",
    "hgnc": "HGNC:3531",
    "summary": null,
    "location": "6p25.1",
    "locusType": "gene with protein product",
    "aliases": [],
    "previousSymbols": [
      "F13A"
    ],
    "ensemblId": "ENSG00000124491",
    "entrezId": 2162,
    "omim": [
      "134570"
    ],
    "uniprot": [
      "P00488"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "6",
      "start": 6144084,
      "end": 6320662,
      "strand": "-",
      "ensemblTranscript": "ENST00000264870.8",
      "refseqTranscript": "NM_000129.4",
      "ensemblProtein": "ENSP00000264870.3",
      "refseqProtein": "NP_000120.2",
      "exons": [
        {
          "start": 6144084,
          "end": 6145772
        },
        {
          "start": 6151813,
          "end": 6151949
        },
        {
          "start": 6167458,
          "end": 6167618
        },
        {
          "start": 6174580,
          "end": 6174867
        },
        {
          "start": 6181988,
          "end": 6182141
        },
        {
          "start": 6195797,
          "end": 6195885
        },
        {
          "start": 6197223,
          "end": 6197326
        },
        {
          "start": 6222033,
          "end": 6222171
        },
        {
          "start": 6224686,
          "end": 6224860
        },
        {
          "start": 6248312,
          "end": 6248419
        },
        {
          "start": 6250811,
          "end": 6250929
        },
        {
          "start": 6266558,
          "end": 6266809
        },
        {
          "start": 6305351,
          "end": 6305539
        },
        {
          "start": 6318535,
          "end": 6318682
        },
        {
          "start": 6320587,
          "end": 6320662
        }
      ],
      "cds": {
        "start": 6145619,
        "end": 6318664
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "6",
      "start": 6144318,
      "end": 6321246,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 5732373,
      "end": 6732372,
      "genes": [
        {
          "symbol": "FARS2",
          "ensemblId": "ENSG00000145982",
          "biotype": "protein_coding",
          "start": 5261007,
          "end": 5829192,
          "strand": "+",
          "slug": "fars2"
        },
        {
          "symbol": "NRN1",
          "ensemblId": "ENSG00000124785",
          "biotype": "protein_coding",
          "start": 5997999,
          "end": 6008688,
          "strand": "-",
          "slug": "nrn1"
        },
        {
          "symbol": "LY86",
          "ensemblId": "ENSG00000112799",
          "biotype": "protein_coding",
          "start": 6588108,
          "end": 6654984,
          "strand": "+",
          "slug": "ly86"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "rare-inherited-coagulation-factor-deficiencies",
        "name": "Rare Inherited Coagulation Factor Deficiencies",
        "diseases": [
          {
            "mondoId": "MONDO:0018029",
            "name": "Congenital Factor XIII Deficiency",
            "genes": 2,
            "inheritance": "autosomal-recessive",
            "description": "A deficiency of the clot-stabilising factor XIII, caused by changes in F13A1 or F13B, that can cause umbilical cord bleeding in newborns, poor wound healing, miscarriage and bleeding inside the skull; routine clotting tests are normal.",
            "management": "Regular preventive factor XIII replacement greatly reduces the risk of serious bleeding.",
            "evidence": {
              "gencc": [
                "ClinGen",
                "Labcorp Genetics (formerly Invitae)",
                "Laboratory for Molecular Medicine",
                "PanelApp Australia"
              ],
              "clingen": "Definitive",
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/hu/conditions/rare-inherited-coagulation-factor-deficiencies"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abnormal-umbilical-stump-bleeding",
        "name": "Abnormal umbilical stump bleeding",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/abnormal-umbilical-stump-bleeding"
      },
      {
        "slug": "menorrhagia",
        "name": "Abnormally heavy bleeding during menstruation",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/menorrhagia"
      },
      {
        "slug": "subcutaneous-hemorrhage",
        "name": "Bleeding below the skin",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/subcutaneous-hemorrhage"
      },
      {
        "slug": "gingival-bleeding",
        "name": "Bleeding gums",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/gingival-bleeding"
      },
      {
        "slug": "cerebral-hemorrhage",
        "name": "Bleeding in brain",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/cerebral-hemorrhage"
      },
      {
        "slug": "post-partum-hemorrhage",
        "name": "Bleeding post-delivery",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/post-partum-hemorrhage"
      },
      {
        "slug": "abnormal-bleeding",
        "name": "Bleeding tendency",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/abnormal-bleeding"
      },
      {
        "slug": "bleeding-with-minor-or-no-trauma",
        "name": "Bleeding with minor or no trauma",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/bleeding-with-minor-or-no-trauma"
      },
      {
        "slug": "joint-hemorrhage",
        "name": "Bleeding within a joint",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/joint-hemorrhage"
      },
      {
        "slug": "intracranial-hemorrhage",
        "name": "Bleeding within the skull",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/intracranial-hemorrhage"
      },
      {
        "slug": "deep-venous-thrombosis",
        "name": "Blood clot in a deep vein",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "url": "https://dantelabs.com/traits/deep-venous-thrombosis"
      },
      {
        "slug": "pulmonary-embolism",
        "name": "Blood clot in artery of lung",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-respiratory-system"
        ],
        "url": "https://dantelabs.com/traits/pulmonary-embolism"
      },
      {
        "slug": "cerebral-venous-thrombosis",
        "name": "Blood clot in cerebral vein",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "url": "https://dantelabs.com/traits/cerebral-venous-thrombosis"
      },
      {
        "slug": "epistaxis",
        "name": "Bloody nose",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/epistaxis"
      },
      {
        "slug": "bruising-susceptibility",
        "name": "Bruising susceptibility",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/bruising-susceptibility"
      },
      {
        "slug": "delayed-onset-bleeding",
        "name": "Delayed onset bleeding",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/delayed-onset-bleeding"
      },
      {
        "slug": "ecchymosis",
        "name": "Ecchymosis",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/ecchymosis"
      },
      {
        "slug": "persistent-bleeding-after-trauma",
        "name": "Excessive bleeding after minor trauma",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/persistent-bleeding-after-trauma"
      },
      {
        "slug": "factor-xiii-subunit-a-deficiency",
        "name": "Factor XIII subunit A deficiency",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/factor-xiii-subunit-a-deficiency"
      },
      {
        "slug": "inflammation-of-the-large-intestine",
        "name": "Inflammation of the large intestine",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/inflammation-of-the-large-intestine"
      },
      {
        "slug": "intramuscular-hematoma",
        "name": "Intramuscular hematoma",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/intramuscular-hematoma"
      },
      {
        "slug": "hepatic-failure",
        "name": "Liver failure",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/hepatic-failure"
      },
      {
        "slug": "myeloid-leukemia",
        "name": "Myeloid leukemia",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-immune-system",
          "neoplasm"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/myeloid-leukemia"
      },
      {
        "slug": "oral-cavity-bleeding",
        "name": "Oral cavity bleeding",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/oral-cavity-bleeding"
      },
      {
        "slug": "poor-wound-healing",
        "name": "Poor wound healing",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/poor-wound-healing"
      },
      {
        "slug": "prolonged-bleeding-after-dental-extraction",
        "name": "Prolonged bleeding after dental extraction",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/prolonged-bleeding-after-dental-extraction"
      },
      {
        "slug": "prolonged-bleeding-after-surgery",
        "name": "Prolonged bleeding after surgery",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/prolonged-bleeding-after-surgery"
      },
      {
        "slug": "prolonged-bleeding-following-circumcision",
        "name": "Prolonged bleeding following circumcision",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/prolonged-bleeding-following-circumcision"
      },
      {
        "slug": "recurrent-thrombophlebitis",
        "name": "Recurrent thrombophlebitis",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "url": "https://dantelabs.com/traits/recurrent-thrombophlebitis"
      },
      {
        "slug": "reduced-factor-xiii-activity",
        "name": "Reduced factor XIII activity",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/reduced-factor-xiii-activity"
      },
      {
        "slug": "spontaneous-hematomas",
        "name": "Spontaneous hematomas",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/spontaneous-hematomas"
      },
      {
        "slug": "thromboembolism",
        "name": "Thromboembolism",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "url": "https://dantelabs.com/traits/thromboembolism"
      },
      {
        "slug": "umbilical-cord-hematoma",
        "name": "Umbilical cord hematoma",
        "systems": [
          "abnormality-of-prenatal-development-or-birth"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/umbilical-cord-hematoma"
      }
    ],
    "related": [
      {
        "slug": "f13b",
        "symbol": "F13B",
        "name": "coagulation factor XIII B chain",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/f13b"
      }
    ],
    "sources": {
      "bundleId": "2026.10.16-c6eea6bf",
      "panel": "2026-10-16",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}