{
  "url": "https://dantelabs.com/hu/genes/cyp2c9",
  "gene": {
    "slug": "cyp2c9",
    "symbol": "CYP2C9",
    "name": "cytochrome P450 family 2 subfamily C member 9",
    "hgnc": "HGNC:2623",
    "summary": null,
    "location": "10q23.33",
    "locusType": "gene with protein product",
    "aliases": [
      "P450IIC9"
    ],
    "previousSymbols": [
      "CYP2C10"
    ],
    "ensemblId": "ENSG00000138109",
    "entrezId": 1559,
    "omim": [
      "601130"
    ],
    "uniprot": [
      "P11712"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "10",
      "start": 94938658,
      "end": 94990091,
      "strand": "+",
      "ensemblTranscript": "ENST00000260682.8",
      "refseqTranscript": "NM_000771.4",
      "ensemblProtein": "ENSP00000260682.6",
      "refseqProtein": "NP_000762.2",
      "exons": [
        {
          "start": 94938658,
          "end": 94938850
        },
        {
          "start": 94941858,
          "end": 94942020
        },
        {
          "start": 94942192,
          "end": 94942341
        },
        {
          "start": 94947779,
          "end": 94947939
        },
        {
          "start": 94949108,
          "end": 94949284
        },
        {
          "start": 94972104,
          "end": 94972245
        },
        {
          "start": 94981183,
          "end": 94981370
        },
        {
          "start": 94986033,
          "end": 94986174
        },
        {
          "start": 94988847,
          "end": 94990091
        }
      ],
      "cds": {
        "start": 94938683,
        "end": 94989028
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "10",
      "start": 96698415,
      "end": 96749147,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
      "start": 94464375,
      "end": 95464374,
      "genes": [
        {
          "symbol": "TBC1D12",
          "ensemblId": "ENSG00000108239",
          "biotype": "protein_coding",
          "start": 94402377,
          "end": 94537452,
          "strand": "+",
          "slug": "tbc1d12"
        },
        {
          "symbol": "HELLS",
          "ensemblId": "ENSG00000119969",
          "biotype": "protein_coding",
          "start": 94545329,
          "end": 94613905,
          "strand": "+",
          "slug": "hells"
        },
        {
          "symbol": "CYP2C18",
          "ensemblId": "ENSG00000108242",
          "biotype": "protein_coding",
          "start": 94682860,
          "end": 94736241,
          "strand": "+",
          "slug": "cyp2c18"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000276490",
          "biotype": "protein_coding",
          "start": 94688154,
          "end": 94853073,
          "strand": "+"
        },
        {
          "symbol": "CYP2C19",
          "ensemblId": "ENSG00000165841",
          "biotype": "protein_coding",
          "start": 94762536,
          "end": 94922264,
          "strand": "+",
          "slug": "cyp2c19"
        },
        {
          "symbol": "CYP2C8",
          "ensemblId": "ENSG00000138115",
          "biotype": "protein_coding",
          "start": 95034359,
          "end": 95069603,
          "strand": "-",
          "slug": "cyp2c8"
        },
        {
          "symbol": "ACSM6",
          "ensemblId": "ENSG00000173124",
          "biotype": "protein_coding",
          "start": 95194200,
          "end": 95228929,
          "strand": "+",
          "slug": "acsm6"
        },
        {
          "symbol": "PDLIM1",
          "ensemblId": "ENSG00000107438",
          "biotype": "protein_coding",
          "start": 95237569,
          "end": 95291126,
          "strand": "-",
          "slug": "pdlim1"
        },
        {
          "symbol": "SORBS1",
          "ensemblId": "ENSG00000095637",
          "biotype": "protein_coding",
          "start": 95311390,
          "end": 95561469,
          "strand": "-",
          "slug": "sorbs1"
        }
      ],
      "truncated": false
    },
    "reports": [],
    "pharmacogenomics": [
      {
        "slug": "pharmacogenomics",
        "title": "Warfarin & NSAID metabolism",
        "summary": "CYP2C9 clears warfarin, phenytoin, and many NSAIDs — including celecoxib, ibuprofen, meloxicam and piroxicam. Reduced-function alleles slow that clearance, lowering the warfarin dose you need and raising exposure to the others.",
        "actionable": [
          "If you are ever started on warfarin, genotype-guided dosing (CYP2C9 + VKORC1 + CYP4F2) can shorten the time to a stable dose.",
          "For NSAIDs such as celecoxib, ibuprofen, flurbiprofen, meloxicam and piroxicam, poor metabolisers may need a lower dose or an alternative — especially for long-term use.",
          "Relevant to the anti-seizure drugs phenytoin and fosphenytoin, where reduced activity raises the risk of toxicity.",
          "Siponimod, a multiple sclerosis treatment, requires CYP2C9 genotyping before it is prescribed and is not used in people with two copies of *3."
        ],
        "caveat": "Calls *2 and *3 plus the *5, *6, *8 and *11 alleles that matter most in African-ancestry populations. The CYP2C-cluster variant rs12777823, which also informs warfarin dosing in that group, is not assessed here.",
        "alleles": [
          {
            "name": "*3",
            "function": "No function",
            "reference": false
          },
          {
            "name": "*6",
            "function": "No function",
            "reference": false
          },
          {
            "name": "*5",
            "function": "Decreased function",
            "reference": false
          },
          {
            "name": "*11",
            "function": "Decreased function",
            "reference": false
          },
          {
            "name": "*1",
            "function": "Normal function",
            "reference": true
          },
          {
            "name": "*2",
            "function": "Decreased function",
            "reference": false
          },
          {
            "name": "*8",
            "function": "Decreased function",
            "reference": false
          }
        ],
        "phenotypes": [
          "Poor Metabolizer",
          "Indeterminate",
          "Normal Metabolizer",
          "Intermediate Metabolizer"
        ],
        "drugs": [
          {
            "name": "celecoxib",
            "cpicLevel": "A",
            "clinpgxLevel": "1A",
            "pgxTesting": "Actionable PGx",
            "guideline": {
              "name": "CYP2C9 and NSAIDs",
              "url": "https://www.clinpgx.org/guideline/PA166251464"
            }
          },
          {
            "name": "flurbiprofen",
            "cpicLevel": "A",
            "clinpgxLevel": "1A",
            "pgxTesting": "Actionable PGx",
            "guideline": {
              "name": "CYP2C9 and NSAIDs",
              "url": "https://www.clinpgx.org/guideline/PA166251464"
            }
          },
          {
            "name": "fluvastatin",
            "cpicLevel": "A",
            "clinpgxLevel": "1A",
            "guideline": {
              "name": "SLCO1B1, ABCG2, CYP2C9, and Statins",
              "url": "https://www.clinpgx.org/guideline/PA166264281"
            }
          },
          {
            "name": "fosphenytoin",
            "cpicLevel": "A",
            "pgxTesting": "Actionable PGx",
            "guideline": {
              "name": "CYP2C9, HLA-B and Phenytoin",
              "url": "https://www.clinpgx.org/guideline/PA166251461"
            }
          },
          {
            "name": "ibuprofen",
            "cpicLevel": "A",
            "clinpgxLevel": "1A",
            "guideline": {
              "name": "CYP2C9 and NSAIDs",
              "url": "https://www.clinpgx.org/guideline/PA166251464"
            }
          },
          {
            "name": "lornoxicam",
            "cpicLevel": "A",
            "clinpgxLevel": "1A",
            "guideline": {
              "name": "CYP2C9 and NSAIDs",
              "url": "https://www.clinpgx.org/guideline/PA166251464"
            }
          },
          {
            "name": "meloxicam",
            "cpicLevel": "A",
            "clinpgxLevel": "1A",
            "pgxTesting": "Informative PGx",
            "guideline": {
              "name": "CYP2C9 and NSAIDs",
              "url": "https://www.clinpgx.org/guideline/PA166251464"
            }
          },
          {
            "name": "phenytoin",
            "cpicLevel": "A",
            "clinpgxLevel": "1A",
            "pgxTesting": "Actionable PGx",
            "guideline": {
              "name": "CYP2C9, HLA-B and Phenytoin",
              "url": "https://www.clinpgx.org/guideline/PA166251461"
            }
          },
          {
            "name": "piroxicam",
            "cpicLevel": "A",
            "clinpgxLevel": "1A",
            "pgxTesting": "Actionable PGx",
            "guideline": {
              "name": "CYP2C9 and NSAIDs",
              "url": "https://www.clinpgx.org/guideline/PA166251464"
            }
          },
          {
            "name": "siponimod",
            "cpicLevel": "A",
            "clinpgxLevel": "1A",
            "pgxTesting": "Testing Required"
          },
          {
            "name": "tenoxicam",
            "cpicLevel": "A",
            "clinpgxLevel": "1A",
            "guideline": {
              "name": "CYP2C9 and NSAIDs",
              "url": "https://www.clinpgx.org/guideline/PA166251464"
            }
          },
          {
            "name": "warfarin",
            "cpicLevel": "A",
            "clinpgxLevel": "1A",
            "pgxTesting": "Actionable PGx",
            "guideline": {
              "name": "CYP2C9, VKORC1, CYP4F2 and Warfarin",
              "url": "https://www.clinpgx.org/guideline/PA166251465"
            }
          },
          {
            "name": "acenocoumarol",
            "cpicLevel": "B",
            "clinpgxLevel": "1B"
          },
          {
            "name": "avatrombopag",
            "cpicLevel": "B/C",
            "pgxTesting": "Informative PGx"
          },
          {
            "name": "dronabinol",
            "cpicLevel": "B/C",
            "pgxTesting": "Actionable PGx"
          },
          {
            "name": "erdafitinib",
            "cpicLevel": "B/C",
            "pgxTesting": "Actionable PGx"
          },
          {
            "name": "lesinurad",
            "cpicLevel": "B/C",
            "pgxTesting": "Actionable PGx"
          },
          {
            "name": "aceclofenac",
            "cpicLevel": "C",
            "guideline": {
              "name": "CYP2C9 and NSAIDs",
              "url": "https://www.clinpgx.org/guideline/PA166251464"
            }
          },
          {
            "name": "aspirin",
            "cpicLevel": "C",
            "guideline": {
              "name": "CYP2C9 and NSAIDs",
              "url": "https://www.clinpgx.org/guideline/PA166251464"
            }
          },
          {
            "name": "diclofenac",
            "cpicLevel": "C",
            "clinpgxLevel": "3",
            "guideline": {
              "name": "CYP2C9 and NSAIDs",
              "url": "https://www.clinpgx.org/guideline/PA166251464"
            }
          },
          {
            "name": "flibanserin",
            "cpicLevel": "C",
            "pgxTesting": "Informative PGx"
          },
          {
            "name": "indomethacin",
            "cpicLevel": "C",
            "clinpgxLevel": "3",
            "guideline": {
              "name": "CYP2C9 and NSAIDs",
              "url": "https://www.clinpgx.org/guideline/PA166251464"
            }
          },
          {
            "name": "lumiracoxib",
            "cpicLevel": "C",
            "guideline": {
              "name": "CYP2C9 and NSAIDs",
              "url": "https://www.clinpgx.org/guideline/PA166251464"
            }
          },
          {
            "name": "nabumetone",
            "cpicLevel": "C",
            "guideline": {
              "name": "CYP2C9 and NSAIDs",
              "url": "https://www.clinpgx.org/guideline/PA166251464"
            }
          },
          {
            "name": "naproxen",
            "cpicLevel": "C",
            "clinpgxLevel": "3",
            "guideline": {
              "name": "CYP2C9 and NSAIDs",
              "url": "https://www.clinpgx.org/guideline/PA166251464"
            }
          }
        ],
        "name": "Pharmacogenomics",
        "url": "https://dantelabs.com/hu/whole-genome-sequencing/pharmacogenomics"
      }
    ],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "systems": [],
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      }
    ],
    "related": [],
    "sources": null,
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}