{
  "url": "https://dantelabs.com/hu/genes/calm2",
  "gene": {
    "slug": "calm2",
    "symbol": "CALM2",
    "name": "calmodulin 2",
    "hgnc": "HGNC:1445",
    "summary": null,
    "location": "2p21",
    "locusType": "gene with protein product",
    "aliases": [
      "PHKD",
      "PHKD2",
      "CAMII"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000143933",
    "entrezId": 805,
    "omim": [
      "114182"
    ],
    "uniprot": [
      "P0DP24"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "2",
      "start": 47160084,
      "end": 47176511,
      "strand": "-",
      "ensemblTranscript": "ENST00000272298.12",
      "refseqTranscript": "NM_001743.6",
      "ensemblProtein": "ENSP00000272298.7",
      "refseqProtein": "NP_001734.1",
      "exons": [
        {
          "start": 47160084,
          "end": 47160804
        },
        {
          "start": 47161723,
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        {
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        {
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        },
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        {
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        }
      ],
      "cds": {
        "start": 47160776,
        "end": 47176443
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "2",
      "start": 47387221,
      "end": 47403740,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 46668298,
      "end": 47668297,
      "genes": [
        {
          "symbol": "CRIPT",
          "ensemblId": "ENSG00000119878",
          "biotype": "protein_coding",
          "start": 46616416,
          "end": 46685037,
          "strand": "+",
          "slug": "cript"
        },
        {
          "symbol": "SOCS5",
          "ensemblId": "ENSG00000171150",
          "biotype": "protein_coding",
          "start": 46698423,
          "end": 46781466,
          "strand": "+",
          "slug": "socs5"
        },
        {
          "symbol": "MCFD2",
          "ensemblId": "ENSG00000180398",
          "biotype": "protein_coding",
          "start": 46895793,
          "end": 46941855,
          "strand": "-",
          "slug": "mcfd2"
        },
        {
          "symbol": "TTC7A",
          "ensemblId": "ENSG00000068724",
          "biotype": "protein_coding",
          "start": 46915869,
          "end": 47076137,
          "strand": "+",
          "slug": "ttc7a"
        },
        {
          "symbol": "STPG4",
          "ensemblId": "ENSG00000239605",
          "biotype": "protein_coding",
          "start": 47045538,
          "end": 47155308,
          "strand": "-",
          "slug": "stpg4"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000273269",
          "biotype": "protein_coding",
          "start": 47065941,
          "end": 47176511,
          "strand": "-"
        },
        {
          "symbol": "EPCAM",
          "ensemblId": "ENSG00000119888",
          "biotype": "protein_coding",
          "start": 47345158,
          "end": 47387601,
          "strand": "+",
          "slug": "epcam"
        },
        {
          "symbol": "MSH2",
          "ensemblId": "ENSG00000095002",
          "biotype": "protein_coding",
          "start": 47403067,
          "end": 47663146,
          "strand": "+",
          "slug": "msh2"
        },
        {
          "symbol": "KCNK12",
          "ensemblId": "ENSG00000184261",
          "biotype": "protein_coding",
          "start": 47509290,
          "end": 47570993,
          "strand": "-",
          "slug": "kcnk12"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "catecholaminergic-polymorphic-ventricular-tachycardia",
        "name": "Catecholaminergic Polymorphic Ventricular Tachycardia",
        "diseases": [
          {
            "mondoId": "MONDO:0008648",
            "name": "Ventricular Tachycardia, Familial",
            "genes": 7,
            "inheritance": null,
            "description": "An instance of ventricular tachycardia that is caused by an inherited modification of the individual's genome.",
            "management": null,
            "evidence": {
              "gencc": [
                "Genomics England PanelApp"
              ],
              "clingen": "Moderate",
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": false,
            "broad": false
          },
          {
            "mondoId": "MONDO:0020575",
            "name": "Polymorphic Ventricular Tachycardia",
            "genes": 7,
            "inheritance": null,
            "description": "A ventricular tachycardia that is irregular in rate and rhythm.",
            "management": null,
            "evidence": {
              "gencc": [
                "Genomics England PanelApp"
              ],
              "clingen": "Moderate",
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/hu/conditions/catecholaminergic-polymorphic-ventricular-tachycardia"
      },
      {
        "slug": "long-qt-syndrome",
        "name": "Long QT Syndrome",
        "diseases": [
          {
            "mondoId": "MONDO:0002442",
            "name": "Long QT Syndrome",
            "genes": 10,
            "inheritance": null,
            "description": "A disorder of cardiac repolarisation marked by a prolonged QT interval and a risk of dangerous ventricular arrhythmias such as torsades de pointes.",
            "management": "Beta-blockers, ICD placement, activity restriction, genetic counseling",
            "evidence": {
              "gencc": [
                "ClinGen",
                "G2P",
                "Labcorp Genetics (formerly Invitae)"
              ],
              "clingen": "Definitive",
              "acmgSf": true,
              "inheritance": [
                "autosomal-dominant"
              ],
              "actionability": 12
            },
            "sameAsReport": true,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/hu/conditions/long-qt-syndrome"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "2-1-atrioventricular-block",
        "name": "2:1 atrioventricular block",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/2-1-atrioventricular-block"
      },
      {
        "slug": "seizure",
        "name": "Epilepsy",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/seizure"
      },
      {
        "slug": "premature-ventricular-contraction",
        "name": "Extra heart beat",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/premature-ventricular-contraction"
      },
      {
        "slug": "syncope",
        "name": "Fainting spell",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/syncope"
      },
      {
        "slug": "cardiac-arrest",
        "name": "Heart stops beating",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/cardiac-arrest"
      },
      {
        "slug": "left-ventricular-noncompaction",
        "name": "Left ventricular noncompaction",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/left-ventricular-noncompaction"
      },
      {
        "slug": "polymorphic-ventricular-tachycardia",
        "name": "Polymorphic ventricular tachycardia",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/polymorphic-ventricular-tachycardia"
      },
      {
        "slug": "prolonged-qtc-interval",
        "name": "Prolonged QTc interval",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/prolonged-qtc-interval"
      },
      {
        "slug": "sinus-bradycardia",
        "name": "Sinus bradycardia",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/sinus-bradycardia"
      },
      {
        "slug": "bradycardia",
        "name": "Slow heartbeats",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/bradycardia"
      },
      {
        "slug": "ventricular-bigeminy",
        "name": "Ventricular bigeminy",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/ventricular-bigeminy"
      },
      {
        "slug": "ventricular-fibrillation",
        "name": "Ventricular fibrillation",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/ventricular-fibrillation"
      }
    ],
    "related": [
      {
        "slug": "calm1",
        "symbol": "CALM1",
        "name": "calmodulin 1",
        "shared": 3,
        "url": "https://dantelabs.com/hu/genes/calm1"
      },
      {
        "slug": "calm3",
        "symbol": "CALM3",
        "name": "calmodulin 3",
        "shared": 3,
        "url": "https://dantelabs.com/hu/genes/calm3"
      },
      {
        "slug": "trdn",
        "symbol": "TRDN",
        "name": "triadin",
        "shared": 3,
        "url": "https://dantelabs.com/hu/genes/trdn"
      },
      {
        "slug": "casq2",
        "symbol": "CASQ2",
        "name": "calsequestrin 2",
        "shared": 2,
        "url": "https://dantelabs.com/hu/genes/casq2"
      },
      {
        "slug": "ryr2",
        "symbol": "RYR2",
        "name": "ryanodine receptor 2",
        "shared": 2,
        "url": "https://dantelabs.com/hu/genes/ryr2"
      },
      {
        "slug": "tecrl",
        "symbol": "TECRL",
        "name": "trans-2,3-enoyl-CoA reductase like",
        "shared": 2,
        "url": "https://dantelabs.com/hu/genes/tecrl"
      },
      {
        "slug": "cacna1c",
        "symbol": "CACNA1C",
        "name": "calcium voltage-gated channel subunit alpha1 C",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/cacna1c"
      },
      {
        "slug": "kcne1",
        "symbol": "KCNE1",
        "name": "potassium voltage-gated channel subfamily E regulatory subunit 1",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/kcne1"
      },
      {
        "slug": "kcnh2",
        "symbol": "KCNH2",
        "name": "potassium voltage-gated channel subfamily H member 2",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/kcnh2"
      },
      {
        "slug": "kcnj2",
        "symbol": "KCNJ2",
        "name": "potassium inwardly rectifying channel subfamily J member 2",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/kcnj2"
      },
      {
        "slug": "kcnq1",
        "symbol": "KCNQ1",
        "name": "potassium voltage-gated channel subfamily Q member 1",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/kcnq1"
      },
      {
        "slug": "scn5a",
        "symbol": "SCN5A",
        "name": "sodium voltage-gated channel alpha subunit 5",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/scn5a"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}