{
  "url": "https://dantelabs.com/hu/genes/cadm3",
  "gene": {
    "slug": "cadm3",
    "symbol": "CADM3",
    "name": "cell adhesion molecule 3",
    "hgnc": "HGNC:17601",
    "summary": null,
    "location": "1q23.2",
    "locusType": "gene with protein product",
    "aliases": [
      "BIgR",
      "FLJ10698",
      "TSLL1",
      "NECL1",
      "SynCAM3",
      "Necl-1"
    ],
    "previousSymbols": [
      "IGSF4B"
    ],
    "ensemblId": "ENSG00000162706",
    "entrezId": 57863,
    "omim": [
      "609743"
    ],
    "uniprot": [
      "Q8N126"
    ],
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      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "1",
      "start": 159171615,
      "end": 159203313,
      "strand": "+",
      "ensemblTranscript": "ENST00000368125.9",
      "refseqTranscript": "NM_001127173.3",
      "ensemblProtein": "ENSP00000357107.4",
      "refseqProtein": "NP_001120645.1",
      "exons": [
        {
          "start": 159171615,
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        },
        {
          "start": 159191936,
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        },
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          "start": 159200804,
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        }
      ],
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        "start": 159171766,
        "end": 159200922
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "1",
      "start": 159141399,
      "end": 159173103,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
      "start": 158687464,
      "end": 159687463,
      "genes": [
        {
          "symbol": "OR6K2",
          "ensemblId": "ENSG00000196171",
          "biotype": "protein_coding",
          "start": 158699678,
          "end": 158700652,
          "strand": "-",
          "slug": "or6k2"
        },
        {
          "symbol": "OR6K3",
          "ensemblId": "ENSG00000203757",
          "biotype": "protein_coding",
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          "end": 158720720,
          "strand": "-",
          "slug": "or6k3"
        },
        {
          "symbol": "OR6N1",
          "ensemblId": "ENSG00000197403",
          "biotype": "protein_coding",
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          "end": 158772195,
          "strand": "-",
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        {
          "symbol": "OR6K6",
          "ensemblId": "ENSG00000180433",
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          "strand": "+",
          "slug": "or6k6"
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        {
          "symbol": "OR6N2",
          "ensemblId": "ENSG00000188340",
          "biotype": "protein_coding",
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          "strand": "-",
          "slug": "or6n2"
        },
        {
          "symbol": "MNDA",
          "ensemblId": "ENSG00000163563",
          "biotype": "protein_coding",
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          "end": 158849517,
          "strand": "+",
          "slug": "mnda"
        },
        {
          "symbol": "PYHIN1",
          "ensemblId": "ENSG00000163564",
          "biotype": "protein_coding",
          "start": 158930779,
          "end": 158977059,
          "strand": "+",
          "slug": "pyhin1"
        },
        {
          "symbol": "IFI16",
          "ensemblId": "ENSG00000163565",
          "biotype": "protein_coding",
          "start": 158999938,
          "end": 159055156,
          "strand": "+",
          "slug": "ifi16"
        },
        {
          "symbol": "PYDC5",
          "ensemblId": "ENSG00000289721",
          "biotype": "protein_coding",
          "start": 158999971,
          "end": 159002751,
          "strand": "-",
          "slug": "pydc5"
        },
        {
          "symbol": "AIM2",
          "ensemblId": "ENSG00000163568",
          "biotype": "protein_coding",
          "start": 159056129,
          "end": 159188222,
          "strand": "-",
          "slug": "aim2"
        },
        {
          "symbol": "ACKR1",
          "ensemblId": "ENSG00000213088",
          "biotype": "protein_coding",
          "start": 159204568,
          "end": 159206500,
          "strand": "+",
          "slug": "ackr1"
        },
        {
          "symbol": "FCER1A",
          "ensemblId": "ENSG00000179639",
          "biotype": "protein_coding",
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          "end": 159308224,
          "strand": "+",
          "slug": "fcer1a"
        },
        {
          "symbol": "OR10J3",
          "ensemblId": "ENSG00000196266",
          "biotype": "protein_coding",
          "start": 159313720,
          "end": 159314659,
          "strand": "-",
          "slug": "or10j3"
        },
        {
          "symbol": "OR10J4",
          "ensemblId": "ENSG00000249730",
          "biotype": "protein_coding",
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          "end": 159433138,
          "strand": "+",
          "slug": "or10j4"
        },
        {
          "symbol": "OR10J1",
          "ensemblId": "ENSG00000196184",
          "biotype": "protein_coding",
          "start": 159437845,
          "end": 159443078,
          "strand": "+",
          "slug": "or10j1"
        },
        {
          "symbol": "OR10J5",
          "ensemblId": "ENSG00000184155",
          "biotype": "protein_coding",
          "start": 159535078,
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          "strand": "-",
          "slug": "or10j5"
        },
        {
          "symbol": "APCS",
          "ensemblId": "ENSG00000132703",
          "biotype": "protein_coding",
          "start": 159587818,
          "end": 159602430,
          "strand": "+",
          "slug": "apcs"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "charcot-marie-tooth-disease-type-1",
        "name": "Charcot-Marie-Tooth Disease",
        "diseases": [
          {
            "mondoId": "MONDO:0015626",
            "name": "Charcot-Marie-Tooth Disease",
            "genes": 62,
            "inheritance": null,
            "description": "A group of inherited peripheral neuropathies causing progressive weakness and wasting of the distal muscles and loss of sensation, mainly in the feet and hands.",
            "management": "Genetic counseling, subtype-specific monitoring, physical therapy, orthotics, neurotoxic drug avoidance, gene-specific clinical trials, surveillance for associated features",
            "evidence": {
              "gencc": [
                "Labcorp Genetics (formerly Invitae)"
              ],
              "clingen": "Moderate",
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": true,
            "broad": true
          }
        ],
        "url": "https://dantelabs.com/hu/conditions/charcot-marie-tooth-disease-type-1"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "absent-achilles-reflex",
        "name": "Absent ankle reflexes",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/absent-achilles-reflex"
      },
      {
        "slug": "areflexia",
        "name": "Absent reflexes",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/areflexia"
      },
      {
        "slug": "brisk-reflexes",
        "name": "Brisk reflexes",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/brisk-reflexes"
      },
      {
        "slug": "decreased-compound-muscle-action-potential-amplitude",
        "name": "Decreased compound muscle action potential amplitude",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/decreased-compound-muscle-action-potential-amplitude"
      },
      {
        "slug": "distal-sensory-impairment",
        "name": "Decreased sensation in extremities",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/distal-sensory-impairment"
      },
      {
        "slug": "delayed-ability-to-walk",
        "name": "Delayed ability to walk",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/delayed-ability-to-walk"
      },
      {
        "slug": "distal-lower-limb-amyotrophy",
        "name": "Distal lower limb amyotrophy",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/distal-lower-limb-amyotrophy"
      },
      {
        "slug": "distal-amyotrophy",
        "name": "Distal muscle wasting",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/distal-amyotrophy"
      },
      {
        "slug": "distal-upper-limb-amyotrophy",
        "name": "Distal upper limb amyotrophy",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/distal-upper-limb-amyotrophy"
      },
      {
        "slug": "distal-upper-limb-muscle-weakness",
        "name": "Distal upper limb muscle weakness",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/distal-upper-limb-muscle-weakness"
      },
      {
        "slug": "pes-planus",
        "name": "Dropped arches",
        "systems": [
          "abnormality-of-limbs"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/pes-planus"
      },
      {
        "slug": "foot-dorsiflexor-weakness",
        "name": "Foot drop",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/foot-dorsiflexor-weakness"
      },
      {
        "slug": "impaired-distal-vibration-sensation",
        "name": "Impaired distal vibration sensation",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/impaired-distal-vibration-sensation"
      },
      {
        "slug": "muscle-spasm",
        "name": "Muscle spasm",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/muscle-spasm"
      },
      {
        "slug": "hypernasal-speech",
        "name": "Nasal speech",
        "systems": [
          "abnormality-of-the-voice"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hypernasal-speech"
      },
      {
        "slug": "patent-ductus-arteriosus",
        "name": "Patent ductus arteriosus",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/patent-ductus-arteriosus"
      },
      {
        "slug": "peripheral-neuropathy",
        "name": "Peripheral neuropathy",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/peripheral-neuropathy"
      },
      {
        "slug": "scoliosis",
        "name": "Scoliosis",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/scoliosis"
      },
      {
        "slug": "weak-grip",
        "name": "Weak grip",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/weak-grip"
      },
      {
        "slug": "weakness-of-facial-musculature",
        "name": "Weakness of facial musculature",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/weakness-of-facial-musculature"
      },
      {
        "slug": "weakness-of-the-intrinsic-hand-muscles",
        "name": "Weakness of the intrinsic hand muscles",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/weakness-of-the-intrinsic-hand-muscles"
      },
      {
        "slug": "wrist-drop",
        "name": "Wrist drop",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/wrist-drop"
      },
      {
        "slug": "wrist-flexion-contracture",
        "name": "Wrist flexion contracture",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/wrist-flexion-contracture"
      }
    ],
    "related": [
      {
        "slug": "aars1",
        "symbol": "AARS1",
        "name": "alanyl-tRNA synthetase 1",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/aars1"
      },
      {
        "slug": "aifm1",
        "symbol": "AIFM1",
        "name": "apoptosis inducing factor mitochondria associated 1",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/aifm1"
      },
      {
        "slug": "atp1a1",
        "symbol": "ATP1A1",
        "name": "ATPase Na+/K+ transporting subunit alpha 1",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/atp1a1"
      },
      {
        "slug": "cox6a1",
        "symbol": "COX6A1",
        "name": "cytochrome c oxidase subunit 6A1",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/cox6a1"
      },
      {
        "slug": "dhtkd1",
        "symbol": "DHTKD1",
        "name": "dehydrogenase E1 and transketolase domain containing 1",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/dhtkd1"
      },
      {
        "slug": "dhx9",
        "symbol": "DHX9",
        "name": "DExH-box helicase 9",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/dhx9"
      },
      {
        "slug": "dnm2",
        "symbol": "DNM2",
        "name": "dynamin 2",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/dnm2"
      },
      {
        "slug": "drp2",
        "symbol": "DRP2",
        "name": "dystrophin related protein 2",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/drp2"
      },
      {
        "slug": "dync1h1",
        "symbol": "DYNC1H1",
        "name": "dynein cytoplasmic 1 heavy chain 1",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/dync1h1"
      },
      {
        "slug": "egr2",
        "symbol": "EGR2",
        "name": "early growth response 2",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/egr2"
      },
      {
        "slug": "fbln5",
        "symbol": "FBLN5",
        "name": "fibulin 5",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/fbln5"
      },
      {
        "slug": "fgd4",
        "symbol": "FGD4",
        "name": "FYVE, RhoGEF and PH domain containing 4",
        "shared": 1,
        "url": "https://dantelabs.com/hu/genes/fgd4"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}