{
  "url": "https://dantelabs.com/hu/genes/brca1",
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        "slug": "dna-repair-disease",
        "name": "DNA Repair Disease",
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      {
        "slug": "fanconi-anemia",
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            "description": "Fanconi anemia (FA) is a hereditary DNA repair disorder characterized by progressive pancytopenia with bone marrow failure, variable congenital malformations and predisposition to develop hematological or solid tumors.",
            "management": "Hematopoietic stem cell transplantation using FA-specific reduced-intensity conditioning; androgens (oxymetholone) as bridge therapy; cancer surveillance for head/neck and gynecological malignancies; gene therapy in clinical trials",
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              "inheritance": [
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            "sameAsReport": true,
            "broad": false
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        ],
        "url": "https://dantelabs.com/hu/conditions/fanconi-anemia"
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      {
        "slug": "hereditary-breast-ovarian-cancer",
        "name": "Hereditary Breast and Ovarian Cancer (BRCA1/2)",
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            "description": "BRCA1 variants that raise the lifetime risk of breast, ovarian and other cancers.",
            "management": "Enhanced breast screening including MRI, consideration of risk-reducing surgery, and testing of relatives.",
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                "Genomics England PanelApp",
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              "clingen": "Definitive",
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          {
            "mondoId": "MONDO:0003582",
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            "description": "A cancer predisposition syndrome, most often due to BRCA1 or BRCA2 variants, with high lifetime risks of breast and ovarian cancer.",
            "management": "Genetic counseling, enhanced screening, risk-reducing surgery",
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                "Labcorp Genetics (formerly Invitae)"
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              "actionability": 10
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            "sameAsReport": false,
            "broad": false
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        ],
        "url": "https://dantelabs.com/hu/conditions/hereditary-breast-ovarian-cancer"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abdominal-distention",
        "name": "Abdominal bloating",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abdominal-distention"
      },
      {
        "slug": "abdominal-pain",
        "name": "Abdominal pain",
        "systems": [
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          "constitutional-symptom"
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        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abdominal-pain"
      },
      {
        "slug": "abnormal-aortic-morphology",
        "name": "Abnormal aortic morphology",
        "systems": [
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        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormal-aortic-morphology"
      },
      {
        "slug": "abnormal-aortic-valve-morphology",
        "name": "Abnormal aortic valve morphology",
        "systems": [
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        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormal-aortic-valve-morphology"
      },
      {
        "slug": "abnormal-cardiac-septum-morphology",
        "name": "Abnormal cardiac septum morphology",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormal-cardiac-septum-morphology"
      },
      {
        "slug": "abnormal-carotid-artery-morphology",
        "name": "Abnormal carotid artery morphology",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormal-carotid-artery-morphology"
      },
      {
        "slug": "tracheoesophageal-fistula",
        "name": "Abnormal connection between trachea and esophagus",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/tracheoesophageal-fistula"
      },
      {
        "slug": "abnormal-fallopian-tube-morphology",
        "name": "Abnormal fallopian tube morphology",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormal-fallopian-tube-morphology"
      },
      {
        "slug": "abnormal-foot-morphology",
        "name": "Abnormal feet structure",
        "systems": [
          "abnormality-of-limbs"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormal-foot-morphology"
      },
      {
        "slug": "abnormal-localization-of-kidney",
        "name": "Abnormal localisation of kidneys",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormal-localization-of-kidney"
      },
      {
        "slug": "abnormal-morphology-of-ulna",
        "name": "Abnormal morphology of ulna",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormal-morphology-of-ulna"
      },
      {
        "slug": "abnormal-preputium-morphology",
        "name": "Abnormal preputium morphology",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormal-preputium-morphology"
      },
      {
        "slug": "abnormal-nervous-system-morphology",
        "name": "Abnormal shape of nervous system",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormal-nervous-system-morphology"
      },
      {
        "slug": "abnormal-skin-pigmentation",
        "name": "Abnormal skin pigmentation",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormal-skin-pigmentation"
      },
      {
        "slug": "neoplasm",
        "name": "Abnormal tissue mass",
        "systems": [],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/neoplasm"
      },
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "systems": [],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      },
      {
        "slug": "abnormality-of-chromosome-stability",
        "name": "Abnormality of chromosome stability",
        "systems": [
          "abnormal-cellular-phenotype",
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormality-of-chromosome-stability"
      },
      {
        "slug": "abnormality-of-the-eye",
        "name": "Abnormality of the eye",
        "systems": [],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormality-of-the-eye"
      },
      {
        "slug": "abnormal-eyelid-morphology",
        "name": "Abnormality of the eyelid",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormal-eyelid-morphology"
      },
      {
        "slug": "abnormality-of-the-hypothalamus-pituitary-axis",
        "name": "Abnormality of the hypothalamus-pituitary axis",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormality-of-the-hypothalamus-pituitary-axis"
      },
      {
        "slug": "abnormality-of-the-liver",
        "name": "Abnormality of the liver",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormality-of-the-liver"
      },
      {
        "slug": "abnormal-testis-morphology",
        "name": "Abnormality of the testis",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormal-testis-morphology"
      },
      {
        "slug": "abnormal-femur-morphology",
        "name": "Abnormality of the thighbone",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormal-femur-morphology"
      },
      {
        "slug": "abnormal-thumb-morphology",
        "name": "Abnormality of the thumb",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormal-thumb-morphology"
      },
      {
        "slug": "abnormality-of-the-upper-limb",
        "name": "Abnormality of the upper limb",
        "systems": [
          "abnormality-of-limbs"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormality-of-the-upper-limb"
      },
      {
        "slug": "abnormality-of-the-uterus",
        "name": "Abnormality of the uterus",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormality-of-the-uterus"
      },
      {
        "slug": "abnormality-of-vision",
        "name": "Abnormality of vision",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormality-of-vision"
      },
      {
        "slug": "abnormal-pinna-morphology",
        "name": "Abnormally shaped ears",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormal-pinna-morphology"
      },
      {
        "slug": "abnormal-renal-morphology",
        "name": "Abnormally shaped kidney",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormal-renal-morphology"
      },
      {
        "slug": "microphthalmia",
        "name": "Abnormally small eyeball",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/microphthalmia"
      },
      {
        "slug": "microcephaly",
        "name": "Abnormally small head",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/microcephaly"
      },
      {
        "slug": "anal-atresia",
        "name": "Absent anus",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/anal-atresia"
      },
      {
        "slug": "azoospermia",
        "name": "Absent sperm in semen",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/azoospermia"
      },
      {
        "slug": "absent-testis",
        "name": "Absent testes",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/absent-testis"
      },
      {
        "slug": "aplasia-hypoplasia-of-fingers",
        "name": "Absent/small fingers",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-of-fingers"
      },
      {
        "slug": "aplasia-hypoplasia-of-the-iris",
        "name": "Absent/small iris",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-of-the-iris"
      },
      {
        "slug": "renal-hypoplasia-aplasia",
        "name": "Absent/small kidney",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/renal-hypoplasia-aplasia"
      },
      {
        "slug": "almond-shaped-palpebral-fissure",
        "name": "Almond shaped eyes",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/almond-shaped-palpebral-fissure"
      },
      {
        "slug": "atrial-septal-defect",
        "name": "An opening in the wall separating the top two chambers of the heart",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/atrial-septal-defect"
      },
      {
        "slug": "anorexia",
        "name": "Anorexia",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/anorexia"
      },
      {
        "slug": "aplasia-hypoplasia-of-the-radius",
        "name": "Aplasia/Hypoplasia of the radius",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-of-the-radius"
      },
      {
        "slug": "aplasia-hypoplasia-of-the-uvula",
        "name": "Aplasia/Hypoplasia of the uvula",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-of-the-uvula"
      },
      {
        "slug": "arteriovenous-malformation",
        "name": "Arteriovenous malformation",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/arteriovenous-malformation"
      },
      {
        "slug": "astigmatism",
        "name": "Astigmatism",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/astigmatism"
      },
      {
        "slug": "proximal-placement-of-thumb",
        "name": "Attachment of thumb close to wrist",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/proximal-placement-of-thumb"
      },
      {
        "slug": "back-pain",
        "name": "Back pain",
        "systems": [
          "abnormality-of-the-musculoskeletal-system",
          "constitutional-symptom"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/back-pain"
      },
      {
        "slug": "dental-malocclusion",
        "name": "Bad bite",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "url": "https://dantelabs.com/traits/dental-malocclusion"
      },
      {
        "slug": "biliary-tract-neoplasm",
        "name": "Biliary tract neoplasm",
        "systems": [
          "abnormality-of-the-digestive-system",
          "neoplasm"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/biliary-tract-neoplasm"
      },
      {
        "slug": "choanal-atresia",
        "name": "Blockage of the rear opening of the nasal cavity",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/choanal-atresia"
      },
      {
        "slug": "breast-carcinoma",
        "name": "Breast cancer",
        "systems": [
          "abnormality-of-the-breast",
          "neoplasm"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/breast-carcinoma"
      },
      {
        "slug": "proptosis",
        "name": "Bulging eye",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/proptosis"
      },
      {
        "slug": "melanoma",
        "name": "Cancer of skin pigment cells",
        "systems": [
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/melanoma"
      },
      {
        "slug": "neoplasm-of-the-pancreas",
        "name": "Cancer of the pancreas",
        "systems": [
          "abnormality-of-the-digestive-system",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/neoplasm-of-the-pancreas"
      },
      {
        "slug": "chromosome-breakage",
        "name": "Chromosome breakage",
        "systems": [
          "abnormal-cellular-phenotype",
          "abnormality-of-metabolism-homeostasis"
        ],
        "url": "https://dantelabs.com/traits/chromosome-breakage"
      },
      {
        "slug": "chronic-fatigue",
        "name": "Chronic fatigue",
        "systems": [
          "constitutional-symptom"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/chronic-fatigue"
      },
      {
        "slug": "acholic-stools",
        "name": "Clay colored stools",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/acholic-stools"
      },
      {
        "slug": "cleft-palate",
        "name": "Cleft palate",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/cleft-palate"
      },
      {
        "slug": "cataract",
        "name": "Clouding of the lens of the eye",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/cataract"
      },
      {
        "slug": "clubbing-of-toes",
        "name": "Clubbed toes",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/clubbing-of-toes"
      },
      {
        "slug": "coarse-facial-features",
        "name": "Coarse facial features",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/coarse-facial-features"
      },
      {
        "slug": "colon-cancer",
        "name": "Colon cancer",
        "systems": [
          "abnormality-of-the-digestive-system",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/colon-cancer"
      },
      {
        "slug": "constipation",
        "name": "Constipation",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/constipation"
      },
      {
        "slug": "cranial-nerve-paralysis",
        "name": "Cranial nerve paralysis",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/cranial-nerve-paralysis"
      },
      {
        "slug": "strabismus",
        "name": "Cross-eyed",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/strabismus"
      },
      {
        "slug": "clinodactyly",
        "name": "Curvature of digit",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/clinodactyly"
      },
      {
        "slug": "clinodactyly-of-the-5th-finger",
        "name": "Curvature of little finger",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/clinodactyly-of-the-5th-finger"
      },
      {
        "slug": "hypogonadism",
        "name": "Decreased activity of gonads",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hypogonadism"
      },
      {
        "slug": "decreased-total-leukocyte-count",
        "name": "Decreased blood leukocyte number",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/decreased-total-leukocyte-count"
      },
      {
        "slug": "decreased-fertility-in-males",
        "name": "Decreased fertility in males",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/decreased-fertility-in-males"
      },
      {
        "slug": "delayed-speech-and-language-development",
        "name": "Delayed speech and language development",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/delayed-speech-and-language-development"
      },
      {
        "slug": "diabetes-mellitus",
        "name": "Diabetes mellitus",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/diabetes-mellitus"
      },
      {
        "slug": "ptosis",
        "name": "Drooping upper eyelid",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/ptosis"
      },
      {
        "slug": "pes-planus",
        "name": "Dropped arches",
        "systems": [
          "abnormality-of-limbs"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/pes-planus"
      },
      {
        "slug": "duodenal-stenosis",
        "name": "Duodenal stenosis",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/duodenal-stenosis"
      },
      {
        "slug": "hypertrophic-cardiomyopathy",
        "name": "Enlarged and thickened heart muscle",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hypertrophic-cardiomyopathy"
      },
      {
        "slug": "aganglionic-megacolon",
        "name": "Enlarged colon lacking nerve cells",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/aganglionic-megacolon"
      },
      {
        "slug": "hepatosplenomegaly",
        "name": "Enlarged liver and spleen",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hepatosplenomegaly"
      },
      {
        "slug": "extrahepatic-cholestasis",
        "name": "Extrahepatic cholestasis",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/extrahepatic-cholestasis"
      },
      {
        "slug": "epicanthus",
        "name": "Eye folds",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/epicanthus"
      },
      {
        "slug": "facial-asymmetry",
        "name": "Facial asymmetry",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/facial-asymmetry"
      },
      {
        "slug": "failure-to-thrive",
        "name": "Faltering weight",
        "systems": [
          "growth-abnormality"
        ],
        "url": "https://dantelabs.com/traits/failure-to-thrive"
      },
      {
        "slug": "fatigue",
        "name": "Fatigue",
        "systems": [
          "constitutional-symptom"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/fatigue"
      },
      {
        "slug": "fever",
        "name": "Fever",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/fever"
      },
      {
        "slug": "finger-syndactyly",
        "name": "Finger syndactyly",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/finger-syndactyly"
      },
      {
        "slug": "triphalangeal-thumb",
        "name": "Finger-like thumb",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/triphalangeal-thumb"
      },
      {
        "slug": "recurrent-urinary-tract-infections",
        "name": "Frequent urinary tract infections",
        "systems": [
          "abnormality-of-the-genitourinary-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/recurrent-urinary-tract-infections"
      },
      {
        "slug": "frontal-bossing",
        "name": "Frontal bossing",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/frontal-bossing"
      },
      {
        "slug": "thick-upper-lip-vermilion",
        "name": "Full upper lip",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "url": "https://dantelabs.com/traits/thick-upper-lip-vermilion"
      },
      {
        "slug": "functional-intestinal-obstruction",
        "name": "Functional intestinal obstruction",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/functional-intestinal-obstruction"
      },
      {
        "slug": "toe-syndactyly",
        "name": "Fused toes",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/toe-syndactyly"
      },
      {
        "slug": "global-developmental-delay",
        "name": "Global developmental delay",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/global-developmental-delay"
      },
      {
        "slug": "growth-delay",
        "name": "Growth delay",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/growth-delay"
      },
      {
        "slug": "hearing-abnormality",
        "name": "Hearing abnormality",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hearing-abnormality"
      },
      {
        "slug": "hearing-impairment",
        "name": "Hearing impairment",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hearing-impairment"
      },
      {
        "slug": "bicornuate-uterus",
        "name": "Heart shaped uterus",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/bicornuate-uterus"
      },
      {
        "slug": "elevated-circulating-hepatic-transaminase-concentration",
        "name": "High liver enzymes",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/elevated-circulating-hepatic-transaminase-concentration"
      },
      {
        "slug": "high-palate",
        "name": "High palate",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/high-palate"
      },
      {
        "slug": "hip-dislocation",
        "name": "Hip dislocation",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hip-dislocation"
      },
      {
        "slug": "hydroureter",
        "name": "Hydroureter",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hydroureter"
      },
      {
        "slug": "hypospadias",
        "name": "Hypospadias",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hypospadias"
      },
      {
        "slug": "exocrine-pancreatic-insufficiency",
        "name": "Inability to properly digest food due to lack of pancreatic digestive enzymes",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/exocrine-pancreatic-insufficiency"
      },
      {
        "slug": "hyperreflexia",
        "name": "Increased reflexes",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hyperreflexia"
      },
      {
        "slug": "macrodontia",
        "name": "Increased size of tooth",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "url": "https://dantelabs.com/traits/macrodontia"
      },
      {
        "slug": "intellectual-disability",
        "name": "Intellectual disability",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/intellectual-disability"
      },
      {
        "slug": "intermittent-diarrhea",
        "name": "Intermittent diarrhea",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/intermittent-diarrhea"
      },
      {
        "slug": "intestinal-pseudo-obstruction",
        "name": "Intestinal pseudo-obstruction",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/intestinal-pseudo-obstruction"
      },
      {
        "slug": "nystagmus",
        "name": "Involuntary, rapid, rhythmic eye movements",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/nystagmus"
      },
      {
        "slug": "irregular-hyperpigmentation",
        "name": "Irregular hyperpigmentation",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/irregular-hyperpigmentation"
      },
      {
        "slug": "pruritus",
        "name": "Itching",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/pruritus"
      },
      {
        "slug": "jaundice",
        "name": "Jaundice",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/jaundice"
      },
      {
        "slug": "micrognathia",
        "name": "Little lower jaw",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/micrognathia"
      },
      {
        "slug": "neoplasm-of-the-liver",
        "name": "Liver cancer",
        "systems": [
          "abnormality-of-the-digestive-system",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/neoplasm-of-the-liver"
      },
      {
        "slug": "long-eyelashes",
        "name": "Long eyelashes",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/long-eyelashes"
      },
      {
        "slug": "dolichocephaly",
        "name": "Long, narrow head",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/dolichocephaly"
      },
      {
        "slug": "low-anterior-hairline",
        "name": "Low frontal hairline",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-integument"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/low-anterior-hairline"
      },
      {
        "slug": "oligohydramnios",
        "name": "Low levels of amniotic fluid",
        "systems": [
          "abnormality-of-prenatal-development-or-birth"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/oligohydramnios"
      },
      {
        "slug": "anemia",
        "name": "Low number of red blood cells or hemoglobin",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/anemia"
      },
      {
        "slug": "thrombocytopenia",
        "name": "Low platelet count",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/thrombocytopenia"
      },
      {
        "slug": "reduced-bone-mineral-density",
        "name": "Low solidness and mass of the bones",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/reduced-bone-mineral-density"
      },
      {
        "slug": "meckel-diverticulum",
        "name": "Meckel diverticulum",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/meckel-diverticulum"
      },
      {
        "slug": "multiple-cafe-au-lait-spots",
        "name": "Multiple birthmarks",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/multiple-cafe-au-lait-spots"
      },
      {
        "slug": "myelodysplasia",
        "name": "Myelodysplasia",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/myelodysplasia"
      },
      {
        "slug": "blepharophimosis",
        "name": "Narrow opening between the eyelids",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "url": "https://dantelabs.com/traits/blepharophimosis"
      },
      {
        "slug": "narrow-palate",
        "name": "Narrow palate",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "url": "https://dantelabs.com/traits/narrow-palate"
      },
      {
        "slug": "anteverted-nares",
        "name": "Nasal tip, upturned",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "url": "https://dantelabs.com/traits/anteverted-nares"
      },
      {
        "slug": "nausea-and-vomiting",
        "name": "Nausea and vomiting",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/nausea-and-vomiting"
      },
      {
        "slug": "ovarian-neoplasm",
        "name": "Ovarian cancer",
        "systems": [
          "abnormality-of-the-genitourinary-system",
          "neoplasm"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/ovarian-neoplasm"
      },
      {
        "slug": "ovarian-carcinoma",
        "name": "Ovarian carcinoma",
        "systems": [
          "abnormality-of-the-genitourinary-system",
          "neoplasm"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/ovarian-carcinoma"
      },
      {
        "slug": "pancreatic-adenocarcinoma",
        "name": "Pancreatic adenocarcinoma",
        "systems": [
          "abnormality-of-the-digestive-system",
          "neoplasm"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/pancreatic-adenocarcinoma"
      },
      {
        "slug": "hypopigmented-skin-patches",
        "name": "Patchy loss of skin color",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/hypopigmented-skin-patches"
      },
      {
        "slug": "patent-ductus-arteriosus",
        "name": "Patent ductus arteriosus",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/patent-ductus-arteriosus"
      },
      {
        "slug": "peritoneal-abscess",
        "name": "Peritoneal abscess",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/peritoneal-abscess"
      },
      {
        "slug": "peritonitis",
        "name": "Peritonitis",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/peritonitis"
      },
      {
        "slug": "poor-appetite",
        "name": "Poor appetite",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/poor-appetite"
      },
      {
        "slug": "intrauterine-growth-retardation",
        "name": "Prenatal growth deficiency",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/intrauterine-growth-retardation"
      },
      {
        "slug": "primary-peritoneal-carcinoma",
        "name": "Primary peritoneal carcinoma",
        "systems": [
          "abnormality-of-the-digestive-system",
          "neoplasm"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/primary-peritoneal-carcinoma"
      },
      {
        "slug": "prominent-nasal-bridge",
        "name": "Prominent nasal bridge",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/prominent-nasal-bridge"
      },
      {
        "slug": "prostate-cancer",
        "name": "Prostate cancer",
        "systems": [
          "abnormality-of-the-genitourinary-system",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/prostate-cancer"
      },
      {
        "slug": "pyridoxine-responsive-sideroblastic-anemia",
        "name": "Pyridoxine-responsive sideroblastic anemia",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/pyridoxine-responsive-sideroblastic-anemia"
      },
      {
        "slug": "renal-insufficiency",
        "name": "Renal failure",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/renal-insufficiency"
      },
      {
        "slug": "scoliosis",
        "name": "Scoliosis",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/scoliosis"
      },
      {
        "slug": "short-palpebral-fissure",
        "name": "Short opening between the eyelids",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/short-palpebral-fissure"
      },
      {
        "slug": "short-stature",
        "name": "Short stature",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/short-stature"
      },
      {
        "slug": "sloping-forehead",
        "name": "Sloping forehead",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/sloping-forehead"
      },
      {
        "slug": "sparse-hair",
        "name": "Sparse hair",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/sparse-hair"
      },
      {
        "slug": "spina-bifida",
        "name": "Split spine",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/spina-bifida"
      },
      {
        "slug": "lymphadenopathy",
        "name": "Swollen lymph nodes",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/lymphadenopathy"
      },
      {
        "slug": "tetralogy-of-fallot",
        "name": "Tetralogy of Fallot",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/tetralogy-of-fallot"
      },
      {
        "slug": "hydrocephalus",
        "name": "Too much cerebrospinal fluid in the brain",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hydrocephalus"
      },
      {
        "slug": "umbilical-hernia",
        "name": "Umbilical hernia",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/umbilical-hernia"
      },
      {
        "slug": "hypoplasia-of-the-ulna",
        "name": "Underdeveloped inner large forearm bone",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hypoplasia-of-the-ulna"
      },
      {
        "slug": "underdeveloped-nasal-alae",
        "name": "Underdeveloped tissue around nostril",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/underdeveloped-nasal-alae"
      },
      {
        "slug": "cryptorchidism",
        "name": "Undescended testes",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/cryptorchidism"
      },
      {
        "slug": "upslanted-palpebral-fissure",
        "name": "Upward slanting of the opening between the eyelids",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/upslanted-palpebral-fissure"
      },
      {
        "slug": "abnormality-of-the-urinary-system",
        "name": "Urinary tract abnormalities",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormality-of-the-urinary-system"
      },
      {
        "slug": "ventriculomegaly",
        "name": "Ventriculomegaly",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/ventriculomegaly"
      },
      {
        "slug": "visual-impairment",
        "name": "Visual impairment",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/visual-impairment"
      },
      {
        "slug": "weight-loss",
        "name": "Weight loss",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/weight-loss"
      },
      {
        "slug": "hypertelorism",
        "name": "Wide-set eyes",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hypertelorism"
      }
    ],
    "related": [
      {
        "slug": "brca2",
        "symbol": "BRCA2",
        "name": "BRCA2 DNA repair associated",
        "shared": 3,
        "url": "https://dantelabs.com/hu/genes/brca2"
      },
      {
        "slug": "brip1",
        "symbol": "BRIP1",
        "name": "BRCA1 interacting DNA helicase 1",
        "shared": 2,
        "url": "https://dantelabs.com/hu/genes/brip1"
      },
      {
        "slug": "ercc4",
        "symbol": "ERCC4",
        "name": "ERCC excision repair 4, endonuclease catalytic subunit",
        "shared": 2,
        "url": "https://dantelabs.com/hu/genes/ercc4"
      },
      {
        "slug": "fanca",
        "symbol": "FANCA",
        "name": "FA complementation group A",
        "shared": 2,
        "url": "https://dantelabs.com/hu/genes/fanca"
      },
      {
        "slug": "fancb",
        "symbol": "FANCB",
        "name": "FA complementation group B",
        "shared": 2,
        "url": "https://dantelabs.com/hu/genes/fancb"
      },
      {
        "slug": "fancc",
        "symbol": "FANCC",
        "name": "FA complementation group C",
        "shared": 2,
        "url": "https://dantelabs.com/hu/genes/fancc"
      },
      {
        "slug": "fancd2",
        "symbol": "FANCD2",
        "name": "FA complementation group D2",
        "shared": 2,
        "url": "https://dantelabs.com/hu/genes/fancd2"
      },
      {
        "slug": "fance",
        "symbol": "FANCE",
        "name": "FA complementation group E",
        "shared": 2,
        "url": "https://dantelabs.com/hu/genes/fance"
      },
      {
        "slug": "fancf",
        "symbol": "FANCF",
        "name": "FA complementation group F",
        "shared": 2,
        "url": "https://dantelabs.com/hu/genes/fancf"
      },
      {
        "slug": "fancg",
        "symbol": "FANCG",
        "name": "FA complementation group G",
        "shared": 2,
        "url": "https://dantelabs.com/hu/genes/fancg"
      },
      {
        "slug": "fanci",
        "symbol": "FANCI",
        "name": "FA complementation group I",
        "shared": 2,
        "url": "https://dantelabs.com/hu/genes/fanci"
      },
      {
        "slug": "fancl",
        "symbol": "FANCL",
        "name": "FA complementation group L",
        "shared": 2,
        "url": "https://dantelabs.com/hu/genes/fancl"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 2450,
    "url": "https://dantelabs.com/genes/brca1/variants",
    "items": [
      {
        "slug": "a92ffs4",
        "name": "A92Ffs*4",
        "commonName": null,
        "symbol": "BRCA1",
        "classification": "pathogenic",
        "stars": 3,
        "hgvsC": "c.273_274del",
        "position": 43104894,
        "grch37Position": 41256911,
        "part": {
          "kind": "exon",
          "number": 5
        },
        "url": "https://dantelabs.com/genes/brca1/variants/a92ffs4"
      },
      {
        "slug": "a134qfs7",
        "name": "A134Qfs*7",
        "commonName": null,
        "symbol": "BRCA1",
        "classification": "pathogenic",
        "stars": 3,
        "hgvsC": "c.399_400del",
        "position": 43104162,
        "grch37Position": 41256179,
        "part": {
          "kind": "exon",
          "number": 6
        },
        "url": "https://dantelabs.com/genes/brca1/variants/a134qfs7"
      },
      {
        "slug": "a302cfs2",
        "name": "A302Cfs*2",
        "commonName": null,
        "symbol": "BRCA1",
        "classification": "pathogenic",
        "stars": 3,
        "hgvsC": "c.903_904insT",
        "position": 43094627,
        "grch37Position": 41246644,
        "part": {
          "kind": "exon",
          "number": 10
        },
        "url": "https://dantelabs.com/genes/brca1/variants/a302cfs2"
      },
      {
        "slug": "a302lfs12",
        "name": "A302Lfs*12",
        "commonName": null,
        "symbol": "BRCA1",
        "classification": "pathogenic",
        "stars": 3,
        "hgvsC": "c.904del",
        "position": 43094626,
        "grch37Position": 41246643,
        "part": {
          "kind": "exon",
          "number": 10
        },
        "url": "https://dantelabs.com/genes/brca1/variants/a302lfs12"
      },
      {
        "slug": "a322kfs2",
        "name": "A322Kfs*2",
        "commonName": null,
        "symbol": "BRCA1",
        "classification": "pathogenic",
        "stars": 3,
        "hgvsC": "c.964_968del",
        "position": 43094562,
        "grch37Position": 41246579,
        "part": {
          "kind": "exon",
          "number": 10
        },
        "url": "https://dantelabs.com/genes/brca1/variants/a322kfs2"
      },
      {
        "slug": "a322lfs19",
        "name": "A322Lfs*19",
        "commonName": null,
        "symbol": "BRCA1",
        "classification": "pathogenic",
        "stars": 3,
        "hgvsC": "c.964del",
        "position": 43094566,
        "grch37Position": 41246583,
        "part": {
          "kind": "exon",
          "number": 10
        },
        "url": "https://dantelabs.com/genes/brca1/variants/a322lfs19"
      },
      {
        "slug": "a407sfs5",
        "name": "A407Sfs*5",
        "commonName": null,
        "symbol": "BRCA1",
        "classification": "pathogenic",
        "stars": 3,
        "hgvsC": "c.1218_1219insA",
        "position": 43094312,
        "grch37Position": 41246329,
        "part": {
          "kind": "exon",
          "number": 10
        },
        "url": "https://dantelabs.com/genes/brca1/variants/a407sfs5"
      },
      {
        "slug": "a433pfs8",
        "name": "A433Pfs*8",
        "commonName": null,
        "symbol": "BRCA1",
        "classification": "pathogenic",
        "stars": 3,
        "hgvsC": "c.1297del",
        "position": 43094233,
        "grch37Position": 41246250,
        "part": {
          "kind": "exon",
          "number": 10
        },
        "url": "https://dantelabs.com/genes/brca1/variants/a433pfs8"
      },
      {
        "slug": "a469qfs6",
        "name": "A469Qfs*6",
        "commonName": null,
        "symbol": "BRCA1",
        "classification": "pathogenic",
        "stars": 3,
        "hgvsC": "c.1405del",
        "position": 43094125,
        "grch37Position": 41246142,
        "part": {
          "kind": "exon",
          "number": 10
        },
        "url": "https://dantelabs.com/genes/brca1/variants/a469qfs6"
      },
      {
        "slug": "a521x",
        "name": "A521X",
        "commonName": null,
        "symbol": "BRCA1",
        "classification": "pathogenic",
        "stars": 3,
        "hgvsC": "c.1561_1564delinsTAAA",
        "position": 43093967,
        "grch37Position": 41245984,
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ATGGCCAAAGGAACAACTCCATGTTTTCTAAAAGGCCTAGAGAACATATATCAGGTGCCTCTCCTCTTTCCCTTTGTGTTCGTCATTTTGGCAAATTACTGAAAGATGGTGGTTCTGGCCAAAAGGAGGAATGACTTTTTAATAGCTGTGTTTGTATCTGAGCCTTCCCTCTGCCTTTCATTTTTTTTGTTTTGTTTTGTTTTGTTTTTGTTTGAGATGAAGTTTCACTTTTGTTGCCCAGGCTGGAGTGCAATGGTGTGATTTCGGCTCATTACAATGTCCGCCTCAGCCTCCTGGGTAGCTGGGATTACAGGCACCCGCCACCACGCCCAGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGCCGGGCTGGTCTCAAACTCCTGACCTCAGGTGATCTGTCCACCTCGGCCTCTCAAAGTGCTGGGATTGTAGGCGTGAGCCACATCACCTGGCCACTTTTTTAACTCTTTCCAATGGTTAATTCCGTTTGATATGGTTCCTTGGAACTTGCACATTACCCTTTATCAATTATCACCCTGTATTGGGGGTGGGGAGGATGATACCTCTCTTCATAGTTAGATCCTACTTACTTTCAACAGAGTTCTTAACAATCCTAGAAACTCACAGGTCCAGAAAAGACAAGCATAAAGGAAACTATAAATAATGCATTTGAAGACTAACTCAGGAAATCAATGATTATTTCCCCCCAGGCTACCCAGTGTCTTAAAAAAACAGTTTAATTAATACAATCTTTTGTTTCAATTTTCTACCTATATTTATGGCTTTTAGCTTTTCTAATAAAAGCTCAAAATGAATTACAGTCATCAGTGACTTTTTAATGAATAGAAGACTTTTGCAATTTTTAACTATTTGTTTTTACTTATTAAATATTTCCGCCTTGGCCAGGCATGGTGGCTCACGCCTATAATCCCAGCACTGTGAGATGCCAAGGCAGGAGGATCACTTGAGTTTAAGAGTTCTAGACCAGGCTGGGTATGGTGGCTCATGCCTATAATCCCAGCACTTTGTGAGGCCAAGGTTGGCGGATCACCTGAGGTCAGGAGTTTAAGACCAGCCTGGCCAACATGGT",
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        "grch37Position": 41230298,
        "part": {
          "kind": "intron",
          "number": 12
        },
        "url": "https://dantelabs.com/genes/brca1/variants/clinvar-allele-262958"
      },
      {
        "slug": "d96n",
        "name": "D96N",
        "commonName": null,
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        "grch37Position": 41256900,
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          "number": 5
        },
        "url": "https://dantelabs.com/genes/brca1/variants/d96n"
      },
      {
        "slug": "d232efs6",
        "name": "D232Efs*6",
        "commonName": null,
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          "number": 10
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        "url": "https://dantelabs.com/genes/brca1/variants/d232efs6"
      },
      {
        "slug": "d295efs2",
        "name": "D295Efs*2",
        "commonName": null,
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        "position": 43094642,
        "grch37Position": 41246659,
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          "kind": "exon",
          "number": 10
        },
        "url": "https://dantelabs.com/genes/brca1/variants/d295efs2"
      },
      {
        "slug": "d295efs8",
        "name": "D295Efs*8",
        "commonName": null,
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        "position": 43094644,
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          "number": 10
        },
        "url": "https://dantelabs.com/genes/brca1/variants/d295efs8"
      },
      {
        "slug": "d295tfs3",
        "name": "D295Tfs*3",
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        "url": "https://dantelabs.com/genes/brca1/variants/d295tfs3"
      },
      {
        "slug": "d369gfs9",
        "name": "D369Gfs*9",
        "commonName": null,
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          "number": 10
        },
        "url": "https://dantelabs.com/genes/brca1/variants/d369gfs9"
      },
      {
        "slug": "d369mfs5",
        "name": "D369Mfs*5",
        "commonName": null,
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          "number": 10
        },
        "url": "https://dantelabs.com/genes/brca1/variants/d369mfs5"
      },
      {
        "slug": "d396efs14",
        "name": "D396Efs*14",
        "commonName": null,
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          "number": 10
        },
        "url": "https://dantelabs.com/genes/brca1/variants/d396efs14"
      },
      {
        "slug": "d397afs13",
        "name": "D397Afs*13",
        "commonName": null,
        "symbol": "BRCA1",
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          "number": 10
        },
        "url": "https://dantelabs.com/genes/brca1/variants/d397afs13"
      },
      {
        "slug": "d411afs7",
        "name": "D411Afs*7",
        "commonName": null,
        "symbol": "BRCA1",
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          "number": 10
        },
        "url": "https://dantelabs.com/genes/brca1/variants/d411afs7"
      },
      {
        "slug": "d411gfs7",
        "name": "D411Gfs*7",
        "commonName": null,
        "symbol": "BRCA1",
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          "number": 10
        },
        "url": "https://dantelabs.com/genes/brca1/variants/d411gfs7"
      },
      {
        "slug": "d411sfs2",
        "name": "D411Sfs*2",
        "commonName": null,
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          "number": 10
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        "url": "https://dantelabs.com/genes/brca1/variants/d411sfs2"
      },
      {
        "slug": "d414efs5",
        "name": "D414Efs*5",
        "commonName": null,
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        "position": 43094289,
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          "number": 10
        },
        "url": "https://dantelabs.com/genes/brca1/variants/d414efs5"
      },
      {
        "slug": "d414gfs5",
        "name": "D414Gfs*5",
        "commonName": null,
        "symbol": "BRCA1",
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          "number": 10
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        "url": "https://dantelabs.com/genes/brca1/variants/d414gfs5"
      },
      {
        "slug": "d414tfs3",
        "name": "D414Tfs*3",
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        "url": "https://dantelabs.com/genes/brca1/variants/d414tfs3"
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      {
        "slug": "d414x",
        "name": "D414X",
        "commonName": null,
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          "number": 10
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        "url": "https://dantelabs.com/genes/brca1/variants/d414x"
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      {
        "slug": "d420mfs10",
        "name": "D420Mfs*10",
        "commonName": null,
        "symbol": "BRCA1",
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        "url": "https://dantelabs.com/genes/brca1/variants/d420mfs10"
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      {
        "slug": "d420rfs2",
        "name": "D420Rfs*2",
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        "symbol": "BRCA1",
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        "url": "https://dantelabs.com/genes/brca1/variants/d420rfs2"
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      {
        "slug": "d430afs6",
        "name": "D430Afs*6",
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        "url": "https://dantelabs.com/genes/brca1/variants/d430afs6"
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      {
        "slug": "d430gfs6",
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        "url": "https://dantelabs.com/genes/brca1/variants/d430gfs6"
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      {
        "slug": "d430rfs6",
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        "url": "https://dantelabs.com/genes/brca1/variants/d430rfs6"
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      {
        "slug": "d435kfs3",
        "name": "D435Kfs*3",
        "commonName": null,
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        "url": "https://dantelabs.com/genes/brca1/variants/d435kfs3"
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      {
        "slug": "d458efs17",
        "name": "D458Efs*17",
        "commonName": null,
        "symbol": "BRCA1",
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        "position": 43094156,
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          "kind": "exon",
          "number": 10
        },
        "url": "https://dantelabs.com/genes/brca1/variants/d458efs17"
      },
      {
        "slug": "d458tfs17",
        "name": "D458Tfs*17",
        "commonName": null,
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        "position": 43094159,
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          "number": 10
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        "url": "https://dantelabs.com/genes/brca1/variants/d458tfs17"
      },
      {
        "slug": "d642x",
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        "commonName": null,
        "symbol": "BRCA1",
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        "position": 43093607,
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          "number": 10
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        "url": "https://dantelabs.com/genes/brca1/variants/d642x"
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      {
        "slug": "d693efs18",
        "name": "D693Efs*18",
        "commonName": null,
        "symbol": "BRCA1",
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        "position": 43093450,
        "grch37Position": 41245467,
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          "kind": "exon",
          "number": 10
        },
        "url": "https://dantelabs.com/genes/brca1/variants/d693efs18"
      },
      {
        "slug": "d693ifs9",
        "name": "D693Ifs*9",
        "commonName": null,
        "symbol": "BRCA1",
        "classification": "pathogenic",
        "stars": 3,
        "hgvsC": "c.2077delinsATA",
        "position": 43093454,
        "grch37Position": 41245471,
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          "kind": "exon",
          "number": 10
        },
        "url": "https://dantelabs.com/genes/brca1/variants/d693ifs9"
      },
      {
        "slug": "d693vfs9",
        "name": "D693Vfs*9",
        "commonName": null,
        "symbol": "BRCA1",
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        "stars": 3,
        "hgvsC": "c.2077_2078insTA",
        "position": 43093453,
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          "kind": "exon",
          "number": 10
        },
        "url": "https://dantelabs.com/genes/brca1/variants/d693vfs9"
      },
      {
        "slug": "d746gfs16",
        "name": "D746Gfs*16",
        "commonName": null,
        "symbol": "BRCA1",
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        "position": 43093294,
        "grch37Position": 41245311,
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          "kind": "exon",
          "number": 10
        },
        "url": "https://dantelabs.com/genes/brca1/variants/d746gfs16"
      },
      {
        "slug": "d749gfs7",
        "name": "D749Gfs*7",
        "commonName": null,
        "symbol": "BRCA1",
        "classification": "pathogenic",
        "stars": 3,
        "hgvsC": "c.2246_2280del",
        "position": 43093250,
        "grch37Position": 41245267,
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          "kind": "exon",
          "number": 10
        },
        "url": "https://dantelabs.com/genes/brca1/variants/d749gfs7"
      },
      {
        "slug": "d749ifs4",
        "name": "D749Ifs*4",
        "commonName": null,
        "symbol": "BRCA1",
        "classification": "pathogenic",
        "stars": 3,
        "hgvsC": "c.2241del",
        "position": 43093289,
        "grch37Position": 41245306,
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          "kind": "exon",
          "number": 10
        },
        "url": "https://dantelabs.com/genes/brca1/variants/d749ifs4"
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}