{
  "url": "https://dantelabs.com/hu/genes/apol1",
  "gene": {
    "slug": "apol1",
    "symbol": "APOL1",
    "name": "apolipoprotein L1",
    "hgnc": "HGNC:618",
    "summary": null,
    "location": "22q12.3",
    "locusType": "gene with protein product",
    "aliases": [],
    "previousSymbols": [
      "APOL"
    ],
    "ensemblId": "ENSG00000100342",
    "entrezId": 8542,
    "omim": [
      "603743"
    ],
    "uniprot": [
      "O14791"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "22",
      "start": 36253133,
      "end": 36267525,
      "strand": "+",
      "ensemblTranscript": "ENST00000397278.8",
      "refseqTranscript": "NM_003661.4",
      "ensemblProtein": "ENSP00000380448.4",
      "refseqProtein": "NP_003652.2",
      "exons": [
        {
          "start": 36253133,
          "end": 36253219
        },
        {
          "start": 36254937,
          "end": 36254999
        },
        {
          "start": 36257083,
          "end": 36257136
        },
        {
          "start": 36257319,
          "end": 36257407
        },
        {
          "start": 36261596,
          "end": 36261722
        },
        {
          "start": 36265151,
          "end": 36267525
        }
      ],
      "cds": {
        "start": 36254956,
        "end": 36266033
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "22",
      "start": 36649056,
      "end": 36663576,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
      "start": 35760329,
      "end": 36760328,
      "genes": [
        {
          "symbol": "RBFOX2",
          "ensemblId": "ENSG00000100320",
          "biotype": "protein_coding",
          "start": 35738736,
          "end": 36028824,
          "strand": "-",
          "slug": "rbfox2"
        },
        {
          "symbol": "APOL3",
          "ensemblId": "ENSG00000128284",
          "biotype": "protein_coding",
          "start": 36139792,
          "end": 36166177,
          "strand": "-",
          "slug": "apol3"
        },
        {
          "symbol": "APOL4",
          "ensemblId": "ENSG00000100336",
          "biotype": "protein_coding",
          "start": 36189124,
          "end": 36204840,
          "strand": "-",
          "slug": "apol4"
        },
        {
          "symbol": "APOL2",
          "ensemblId": "ENSG00000128335",
          "biotype": "protein_coding",
          "start": 36220307,
          "end": 36239954,
          "strand": "-",
          "slug": "apol2"
        },
        {
          "symbol": "MYH9",
          "ensemblId": "ENSG00000100345",
          "biotype": "protein_coding",
          "start": 36281277,
          "end": 36388018,
          "strand": "-",
          "slug": "myh9"
        },
        {
          "symbol": "TXN2",
          "ensemblId": "ENSG00000100348",
          "biotype": "protein_coding",
          "start": 36466895,
          "end": 36482072,
          "strand": "-",
          "slug": "txn2"
        },
        {
          "symbol": "FOXRED2",
          "ensemblId": "ENSG00000100350",
          "biotype": "protein_coding",
          "start": 36487190,
          "end": 36507221,
          "strand": "-",
          "slug": "foxred2"
        },
        {
          "symbol": "EIF3D",
          "ensemblId": "ENSG00000100353",
          "biotype": "protein_coding",
          "start": 36510847,
          "end": 36529245,
          "strand": "-",
          "slug": "eif3d"
        },
        {
          "symbol": "CACNG2",
          "ensemblId": "ENSG00000166862",
          "biotype": "protein_coding",
          "start": 36560857,
          "end": 36703779,
          "strand": "-",
          "slug": "cacng2"
        },
        {
          "symbol": "IFT27",
          "ensemblId": "ENSG00000100360",
          "biotype": "protein_coding",
          "start": 36741346,
          "end": 36776309,
          "strand": "-",
          "slug": "ift27"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "focal-segmental-glomerulosclerosis",
        "name": "Focal Segmental Glomerulosclerosis",
        "diseases": [
          {
            "mondoId": "MONDO:0012931",
            "name": "FSGS Susceptibility (APOL1)",
            "genes": 1,
            "inheritance": "autosomal-recessive",
            "description": "Two APOL1 risk variants (G1 or G2) markedly increase the risk of FSGS and other non-diabetic kidney disease, mainly in people with recent African ancestry; most people with this genotype never develop kidney disease.",
            "management": "Knowing can prompt blood pressure and kidney function monitoring and informs evaluation of living kidney donors.",
            "evidence": {
              "gencc": [
                "ClinGen",
                "Labcorp Genetics (formerly Invitae)"
              ],
              "clingen": "Definitive",
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/hu/conditions/focal-segmental-glomerulosclerosis"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abdominal-pain",
        "name": "Abdominal pain",
        "systems": [
          "abnormality-of-the-digestive-system",
          "constitutional-symptom"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abdominal-pain"
      },
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "systems": [],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      },
      {
        "slug": "chronic-kidney-disease",
        "name": "Chronic kidney disease",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/chronic-kidney-disease"
      },
      {
        "slug": "diffuse-mesangial-sclerosis",
        "name": "Diffuse mesangial sclerosis",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/diffuse-mesangial-sclerosis"
      },
      {
        "slug": "fever",
        "name": "Fever",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/fever"
      },
      {
        "slug": "edema",
        "name": "Fluid retention",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/edema"
      },
      {
        "slug": "foamy-urine",
        "name": "Foamy urine",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/foamy-urine"
      },
      {
        "slug": "focal-segmental-glomerulosclerosis",
        "name": "Focal segmental glomerulosclerosis",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/focal-segmental-glomerulosclerosis"
      },
      {
        "slug": "headache",
        "name": "Headache",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/headache"
      },
      {
        "slug": "proteinuria",
        "name": "High urine protein levels",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/proteinuria"
      },
      {
        "slug": "irritability",
        "name": "Irritability",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/irritability"
      },
      {
        "slug": "hypoalbuminemia",
        "name": "Low albumin",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hypoalbuminemia"
      },
      {
        "slug": "minimal-change-glomerulonephritis",
        "name": "Minimal change glomerulonephritis",
        "systems": [
          "abnormality-of-the-genitourinary-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/minimal-change-glomerulonephritis"
      },
      {
        "slug": "periorbital-edema",
        "name": "Periorbital edema",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/periorbital-edema"
      },
      {
        "slug": "peritonitis",
        "name": "Peritonitis",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/peritonitis"
      },
      {
        "slug": "respiratory-tract-infection",
        "name": "Respiratory tract infection",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/respiratory-tract-infection"
      },
      {
        "slug": "stage-5-chronic-kidney-disease",
        "name": "Stage 5 chronic kidney disease",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/stage-5-chronic-kidney-disease"
      }
    ],
    "related": [],
    "sources": {
      "bundleId": "2026.10.16-c6eea6bf",
      "panel": "2026-10-16",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}