--- title: "TP53 F113V (c.337T>G, rs587781642) | Dante Labs" description: "ClinVar classifies TP53 F113V as Likely pathogenic (reviewed by expert panel). Where it sits in the genome, its predicted effect, and the Genome Test reports that look at it." url: "https://dantelabs.com/genes/tp53/variants/f113v" --- 1. [Genes](https://dantelabs.com/genes) 2. [TP53](https://dantelabs.com/genes/tp53) 3. TP53 F113V Variant # TP53 F113V NM_000546.6(TP53):c.337T>G (p.Phe113Val) Also known as - p.Phe113Val - p.F113V - rs587781642 * ClinVar classification Likely pathogenic * Review status 3 stars out of 4 reviewed by expert panel * Last evaluated 1 July 2026 * Expert panel ClinGen TP53 Variant Curation Expert Panel, ClinGen Data current to ClinVar release 2026-10-12 · Dante Labs data release 2026.10.17-8666dff2 Facts last changed 17 October 2026 ## Summary F113V is a missense variant in TP53: it changes a single amino acid in the protein the gene encodes. ClinVar classifies it as likely pathogenic for Li-Fraumeni Syndrome (reviewed by expert panel). ## ClinVar classifications | Condition | Classification | Review status | Submissions | Last evaluated | | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | ----------------- | ----------------------------------------- | ------------ | -------------- | | [Li-Fraumeni Syndrome](https://dantelabs.com/conditions/li-fraumeni-syndrome) [ClinVar VCV000141302 (opens in a new tab)](https://www.ncbi.nlm.nih.gov/clinvar/variation/141302/) | Likely pathogenic | 3 stars out of 4 reviewed by expert panel | 1 submission | 1 July 2026 | Classifications as ClinVar records them in release 2026-10-12. ClinVar updates them as evidence is reviewed. ## ACMG/AMP criteria The ACMG/AMP criteria F113V meets, from its predicted effect in TP53, gnomAD and ClinVar. | Criterion | Strength | Rests on | | ----------------------------------------------- | ---------- | ----------------------------------------------------- | | PP5 A reputable source reports it as pathogenic | Supporting | ClinVar: Likely pathogenic (reviewed by expert panel) | On these criteria alone: uncertain significance. Assessed automatically, without functional, computational or family evidence. Not a clinical classification. ## Where it lies in TP53 F113V lies in exon 4 of the 11 in TP53's MANE Select transcript, NM_000546.6. [TP53 variants in exon 4 →](https://dantelabs.com/genes/tp53/variants?exon=4) [TP53's gene diagram →](https://dantelabs.com/genes/tp53#gene-structure) ## Molecular details | Gene | [TP53](https://dantelabs.com/genes/tp53) | | --------------------------- | ----------------------------------------------------------------------------------------------------------------------------------------------- | | Transcript | NM_000546.6 MANE Select | | Coding DNA change (HGVS c.) | c.337T>G | | Protein change (HGVS p.) | p.Phe113Val p.F113V | | Predicted consequence | Missense [missense_variant (opens in a new tab)](https://purl.obolibrary.org/obo/SO_0001583) | | Predicted impact | Moderate | | Position (GRCh38) | chr17:7676032 A>C | | Position (GRCh37) | chr17:7579350 A>C | | dbSNP ID | [rs587781642 (opens in a new tab)](https://www.ncbi.nlm.nih.gov/snp/rs587781642) | | ClinVar Variation ID | [VCV000141302 (opens in a new tab)](https://www.ncbi.nlm.nih.gov/clinvar/variation/141302/) | | ClinVar Allele ID | 151016 | | ClinGen Allele Registry ID | [CA000124 (opens in a new tab)](https://reg.clinicalgenome.org/redmine/projects/registry/genboree_registry/by_canonicalid?canonicalid=CA000124) | | ClinVar name | NM_000546.6(TP53):c.337T>G (p.Phe113Val) | ## TP53 F113V in other databases - [ClinVar VCV000141302 (opens in a new tab)](https://www.ncbi.nlm.nih.gov/clinvar/variation/141302/) - [dbSNP rs587781642 (opens in a new tab)](https://www.ncbi.nlm.nih.gov/snp/rs587781642) - [ClinGen Allele Registry CA000124 (opens in a new tab)](https://reg.clinicalgenome.org/redmine/projects/registry/genboree_registry/by_canonicalid?canonicalid=CA000124) - [gnomAD 17-7676032-A-C (opens in a new tab)](https://gnomad.broadinstitute.org/variant/17-7676032-A-C?dataset=gnomad_r4) - [Ensembl rs587781642 (opens in a new tab)](https://www.ensembl.org/Homo_sapiens/Variation/Explore?v=rs587781642) ## Reports that look at this variant (1) These Genome Test condition reports include F113V among the variants they look at. | Report | Conditions | Inheritance | | ----------------------------------------------------------------------------- | -------------------- | ------------------ | | [Li-Fraumeni Syndrome](https://dantelabs.com/conditions/li-fraumeni-syndrome) | Li-Fraumeni Syndrome | Autosomal dominant | ## Other variants in TP53 - [A138P Likely pathogenic 3 stars out of 4](https://dantelabs.com/genes/tp53/variants/a138p) - [A138V Likely pathogenic 3 stars out of 4](https://dantelabs.com/genes/tp53/variants/a138v) - [A161_Y163delinsD Likely pathogenic 3 stars out of 4](https://dantelabs.com/genes/tp53/variants/a161-y163delinsd) - [A347D Pathogenic 3 stars out of 4](https://dantelabs.com/genes/tp53/variants/a347d) - [c.-29+1G>T Likely pathogenic 3 stars out of 4](https://dantelabs.com/genes/tp53/variants/c--29plus1g-t) - [c.97-1G>A Pathogenic 3 stars out of 4](https://dantelabs.com/genes/tp53/variants/c-97-1g-a) - [c.375+5G>A Likely pathogenic 3 stars out of 4](https://dantelabs.com/genes/tp53/variants/c-375plus5g-a) - [c.919+1G>A Pathogenic 3 stars out of 4](https://dantelabs.com/genes/tp53/variants/c-919plus1g-a) - [c.993+1del Likely pathogenic 3 stars out of 4](https://dantelabs.com/genes/tp53/variants/c-993plus1del) - [C124X Pathogenic 3 stars out of 4](https://dantelabs.com/genes/tp53/variants/c124x) [All TP53 variants](https://dantelabs.com/genes/tp53/variants) ## Limitations This page describes publicly available information about a genetic variant. It is not a diagnosis, and it says nothing about whether you or anyone else carries this variant. Classifications come from ClinVar and change as new evidence is reviewed. A classification here may differ from the one in ClinVar today, or from the one a laboratory reports. Whole genome sequencing with short reads can miss or miscall some variants, particularly in repeated or highly similar stretches of DNA and in large insertions, deletions or rearrangements. If you have questions about a variant in your own results or in your family, talk to a genetic counsellor or your doctor. ## Sources & credits - Classifications from ClinVar (release 2026-10-12), National Center for Biotechnology Information. - Condition terms from the Mondo Disease Ontology (release 2026-10-06), used under CC BY 4.0. - Gene symbols and names from the HUGO Gene Nomenclature Committee (release 2026-10-16). - Allele identifiers from the ClinGen Allele Registry (release 2026-10-17-c4908f54). - Reference SNP identifiers from dbSNP (release b157), National Center for Biotechnology Information. - Gene–disease links from the Gene Curation Coalition, GenCC (release 2026-10-17). - Difficult regions from the Genome in a Bottle Consortium (release v3.6). - Transcripts from MANE (release v1.5), NCBI and EMBL-EBI. - Predicted consequences from mehari (release 0.11.0), with transcript models from cdot. - Built from Dante Labs data release 2026.10.17-8666dff2 of 17 October 2026. ## Cite this page APA > Dante Labs. (17 October 2026). TP53 F113V (c.337T>G, rs587781642) (Version 2026.10.17-8666dff2). Retrieved 17 October 2026, from https\://dantelabs.com/genes/tp53/variants/f113v Vancouver > Dante Labs. TP53 F113V (c.337T>G, rs587781642) \[Internet]. Version 2026.10.17-8666dff2. 17 October 2026 \[cited 17 October 2026]. Available from: https\://dantelabs.com/genes/tp53/variants/f113v Download citation [RIS](https://dantelabs.com/genes/tp53/variants/f113v/cite.ris) [BibTeX](https://dantelabs.com/genes/tp53/variants/f113v/cite.bib) [CSL-JSON](https://dantelabs.com/genes/tp53/variants/f113v/cite.json) ## Read your whole genome From $449 Free shipping · Results in 6–8 weeks [Explore the Genome Test](https://dantelabs.com/whole-genome-sequencing)