{
  "url": "https://dantelabs.com/genes/sdhc",
  "gene": {
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    "symbol": "SDHC",
    "name": "succinate dehydrogenase complex subunit C",
    "hgnc": "HGNC:10682",
    "summary": null,
    "location": "1q23.3",
    "locusType": "gene with protein product",
    "aliases": [
      "CYB560",
      "cybL"
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      "602413"
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      "Q99643"
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      "strand": "+",
      "ensemblTranscript": "ENST00000367975.7",
      "refseqTranscript": "NM_003001.5",
      "ensemblProtein": "ENSP00000356953.3",
      "refseqProtein": "NP_002992.1",
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          "end": 161314425
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    },
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      "strand": "+"
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        {
          "symbol": "CD244",
          "ensemblId": "ENSG00000122223",
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        {
          "symbol": "F11R",
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        {
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          "ensemblId": "ENSG00000270149",
          "biotype": "protein_coding",
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        {
          "symbol": "TSTD1",
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          "biotype": "protein_coding",
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        {
          "symbol": "USF1",
          "ensemblId": "ENSG00000158773",
          "biotype": "protein_coding",
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          "strand": "-",
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        {
          "symbol": "ARHGAP30",
          "ensemblId": "ENSG00000186517",
          "biotype": "protein_coding",
          "start": 161046944,
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          "strand": "-",
          "slug": "arhgap30"
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        {
          "symbol": "NECTIN4",
          "ensemblId": "ENSG00000143217",
          "biotype": "protein_coding",
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          "strand": "-",
          "slug": "nectin4"
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        {
          "symbol": "KLHDC9",
          "ensemblId": "ENSG00000162755",
          "biotype": "protein_coding",
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          "strand": "+",
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        {
          "symbol": "PFDN2",
          "ensemblId": "ENSG00000143256",
          "biotype": "protein_coding",
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        {
          "symbol": "NIT1",
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          "biotype": "protein_coding",
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        {
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        {
          "symbol": "USP21",
          "ensemblId": "ENSG00000143258",
          "biotype": "protein_coding",
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          "slug": "usp21"
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        {
          "symbol": "PPOX",
          "ensemblId": "ENSG00000143224",
          "biotype": "protein_coding",
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          "strand": "+",
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        {
          "symbol": "B4GALT3",
          "ensemblId": "ENSG00000158850",
          "biotype": "protein_coding",
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        {
          "symbol": "ADAMTS4",
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          "biotype": "protein_coding",
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        {
          "symbol": "NDUFS2",
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          "biotype": "protein_coding",
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        {
          "symbol": "FCER1G",
          "ensemblId": "ENSG00000158869",
          "biotype": "protein_coding",
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        {
          "symbol": "APOA2",
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          "biotype": "protein_coding",
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        {
          "symbol": "TOMM40L",
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          "biotype": "protein_coding",
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          "symbol": "NR1I3",
          "ensemblId": "ENSG00000143257",
          "biotype": "protein_coding",
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          "strand": "-",
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        {
          "symbol": "PCP4L1",
          "ensemblId": "ENSG00000248485",
          "biotype": "protein_coding",
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          "strand": "+",
          "slug": "pcp4l1"
        },
        {
          "symbol": "MPZ",
          "ensemblId": "ENSG00000158887",
          "biotype": "protein_coding",
          "start": 161304735,
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          "strand": "-",
          "slug": "mpz"
        },
        {
          "symbol": "CFAP126",
          "ensemblId": "ENSG00000188931",
          "biotype": "protein_coding",
          "start": 161364733,
          "end": 161367885,
          "strand": "-",
          "slug": "cfap126"
        },
        {
          "symbol": "FCGR2A",
          "ensemblId": "ENSG00000143226",
          "biotype": "protein_coding",
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          "end": 161524013,
          "strand": "+",
          "slug": "fcgr2a"
        },
        {
          "symbol": "HSPA6",
          "ensemblId": "ENSG00000173110",
          "biotype": "protein_coding",
          "start": 161524540,
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          "strand": "+",
          "slug": "hspa6"
        },
        {
          "symbol": "FCGR3A",
          "ensemblId": "ENSG00000203747",
          "biotype": "protein_coding",
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          "strand": "-",
          "slug": "fcgr3a"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000289768",
          "biotype": "protein_coding",
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          "end": 161631456,
          "strand": "-"
        },
        {
          "symbol": "FCGR2C",
          "ensemblId": "ENSG00000244682",
          "biotype": "protein_coding",
          "start": 161581339,
          "end": 161605662,
          "strand": "+",
          "slug": "fcgr2c"
        },
        {
          "symbol": "FCGR3B",
          "ensemblId": "ENSG00000162747",
          "biotype": "protein_coding",
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          "end": 161631963,
          "strand": "-",
          "slug": "fcgr3b"
        },
        {
          "symbol": "FCGR2B",
          "ensemblId": "ENSG00000072694",
          "biotype": "protein_coding",
          "start": 161661958,
          "end": 161679490,
          "strand": "+",
          "slug": "fcgr2b"
        },
        {
          "symbol": "FCRLA",
          "ensemblId": "ENSG00000132185",
          "biotype": "protein_coding",
          "start": 161706958,
          "end": 161714352,
          "strand": "+",
          "slug": "fcrla"
        },
        {
          "symbol": "FCRLB",
          "ensemblId": "ENSG00000162746",
          "biotype": "protein_coding",
          "start": 161721544,
          "end": 161731801,
          "strand": "+",
          "slug": "fcrlb"
        },
        {
          "symbol": "DUSP12",
          "ensemblId": "ENSG00000081721",
          "biotype": "protein_coding",
          "start": 161749758,
          "end": 161757238,
          "strand": "+",
          "slug": "dusp12"
        },
        {
          "symbol": "ATF6",
          "ensemblId": "ENSG00000118217",
          "biotype": "protein_coding",
          "start": 161766243,
          "end": 161977574,
          "strand": "+",
          "slug": "atf6"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "hereditary-gastrointestinal-stromal-tumour",
        "name": "Hereditary Gastrointestinal Stromal Tumour",
        "diseases": [
          {
            "mondoId": "MONDO:0011719",
            "name": "Hereditary Gastrointestinal Stromal Tumour",
            "genes": 4,
            "inheritance": "autosomal-dominant",
            "description": "Most GISTs are caused by changes acquired in the tumour itself. In familial GIST, a person inherits a change in one copy of KIT or PDGFRA that switches the gene on, or a change that stops SDHB or SDHC from working (Carney-Stratakis syndrome).",
            "management": "Specialist surveillance with endoscopy and imaging is offered, and SDHB or SDHC carriers are also screened for paragangliomas and phaeochromocytomas. Response to treatment varies by gene and genotype, and SDH-deficient GISTs generally respond poorly to standard tyrosine kinase inhibitors. Genetic counselling and testing of relatives are recommended.",
            "evidence": {
              "gencc": [
                "Genomics England PanelApp",
                "Labcorp Genetics (formerly Invitae)"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": true,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/conditions/hereditary-gastrointestinal-stromal-tumour"
      },
      {
        "slug": "hereditary-pheochromocytoma-paraganglioma",
        "name": "Hereditary Pheochromocytoma and Paraganglioma",
        "diseases": [
          {
            "mondoId": "MONDO:0011740",
            "name": "Carney-Stratakis syndrome",
            "genes": 3,
            "inheritance": "autosomal-dominant",
            "description": "A combination of paraganglioma and gastrointestinal stromal tumour caused by variants in the SDH genes.",
            "management": "Surveillance covers both paragangliomas and gastrointestinal stromal tumours.",
            "evidence": {
              "gencc": [
                "Genomics England PanelApp"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": false,
            "broad": false
          },
          {
            "mondoId": "MONDO:0017366",
            "name": "Hereditary pheochromocytoma-paraganglioma",
            "genes": 7,
            "inheritance": "autosomal-dominant",
            "description": "A group of syndromes (PPGL types 1-7, TMEM127- and MAX-related) in which variants in SDHB, SDHD, SDHC, SDHA, SDHAF2, MAX or TMEM127 raise the risk of pheochromocytoma and paraganglioma.",
            "management": "Regular blood or urine metanephrine testing and periodic whole-body MRI help find tumours early, before they cause blood-pressure crises; relatives can be offered testing.",
            "evidence": {
              "gencc": [
                "Ambry Genetics",
                "ClinGen",
                "G2P",
                "Labcorp Genetics (formerly Invitae)"
              ],
              "clingen": "Definitive",
              "acmgSf": true,
              "inheritance": [
                "autosomal-dominant"
              ],
              "actionability": 11
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/conditions/hereditary-pheochromocytoma-paraganglioma"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abdominal-mass",
        "name": "Abdominal mass",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abdominal-mass"
      },
      {
        "slug": "abdominal-pain",
        "name": "Abdominal pain",
        "systems": [
          "abnormality-of-the-digestive-system",
          "constitutional-symptom"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abdominal-pain"
      },
      {
        "slug": "arrhythmia",
        "name": "Abnormal heart rate",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/arrhythmia"
      },
      {
        "slug": "abnormality-of-the-liver",
        "name": "Abnormality of the liver",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormality-of-the-liver"
      },
      {
        "slug": "aniridia",
        "name": "Absent iris",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/aniridia"
      },
      {
        "slug": "ascites",
        "name": "Accumulation of fluid in the abdomen",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/ascites"
      },
      {
        "slug": "adrenal-overactivity",
        "name": "Adrenal overactivity",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/adrenal-overactivity"
      },
      {
        "slug": "adrenal-pheochromocytoma",
        "name": "Adrenal pheochromocytoma",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-nervous-system",
          "neoplasm"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/adrenal-pheochromocytoma"
      },
      {
        "slug": "adrenocortical-adenoma",
        "name": "Adrenocortical adenoma",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "neoplasm"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/adrenocortical-adenoma"
      },
      {
        "slug": "anorexia",
        "name": "Anorexia",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/anorexia"
      },
      {
        "slug": "arachnoid-hemangiomatosis",
        "name": "Arachnoid hemangiomatosis",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/arachnoid-hemangiomatosis"
      },
      {
        "slug": "cerebral-hemorrhage",
        "name": "Bleeding in brain",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/cerebral-hemorrhage"
      },
      {
        "slug": "hematuria",
        "name": "Blood in urine",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hematuria"
      },
      {
        "slug": "sarcoma",
        "name": "Cancer of connective tissue",
        "systems": [
          "neoplasm"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/sarcoma"
      },
      {
        "slug": "renal-cell-carcinoma",
        "name": "Cancer starting in small tubes in kidneys",
        "systems": [
          "abnormality-of-the-genitourinary-system",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/renal-cell-carcinoma"
      },
      {
        "slug": "congestive-heart-failure",
        "name": "Cardiac failure",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/congestive-heart-failure"
      },
      {
        "slug": "chemodectoma",
        "name": "Chemodectoma",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-nervous-system",
          "neoplasm"
        ],
        "url": "https://dantelabs.com/traits/chemodectoma"
      },
      {
        "slug": "chest-pain",
        "name": "Chest pain",
        "systems": [
          "constitutional-symptom"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/chest-pain"
      },
      {
        "slug": "neoplasm-of-the-colon",
        "name": "Colon tumor",
        "systems": [
          "abnormality-of-the-digestive-system",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/neoplasm-of-the-colon"
      },
      {
        "slug": "conductive-hearing-impairment",
        "name": "Conductive deafness",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/conductive-hearing-impairment"
      },
      {
        "slug": "constipation",
        "name": "Constipation",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/constipation"
      },
      {
        "slug": "cranial-nerve-compression",
        "name": "Cranial nerve compression",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/cranial-nerve-compression"
      },
      {
        "slug": "cranial-nerve-paralysis",
        "name": "Cranial nerve paralysis",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/cranial-nerve-paralysis"
      },
      {
        "slug": "orthostatic-hypotension",
        "name": "Decrease in blood pressure upon standing up",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/orthostatic-hypotension"
      },
      {
        "slug": "diarrhea",
        "name": "Diarrhea",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/diarrhea"
      },
      {
        "slug": "cardiomyopathy",
        "name": "Disease of the heart muscle",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/cardiomyopathy"
      },
      {
        "slug": "elevated-circulating-calcitonin-concentration",
        "name": "Elevated calcitonin",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/elevated-circulating-calcitonin-concentration"
      },
      {
        "slug": "elevated-circulating-catecholamine-level",
        "name": "Elevated circulating catecholamine level",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "url": "https://dantelabs.com/traits/elevated-circulating-catecholamine-level"
      },
      {
        "slug": "tachycardia",
        "name": "Elevated heart rate",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/tachycardia"
      },
      {
        "slug": "elevated-urinary-dopamine-level",
        "name": "Elevated urinary dopamine",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/elevated-urinary-dopamine-level"
      },
      {
        "slug": "elevated-urinary-epinephrine-level",
        "name": "Elevated urinary epinephrine level",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/elevated-urinary-epinephrine-level"
      },
      {
        "slug": "elevated-urinary-norepinephrine-level",
        "name": "Elevated urinary norepinephrine level",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/elevated-urinary-norepinephrine-level"
      },
      {
        "slug": "episodic-paroxysmal-anxiety",
        "name": "Episodic paroxysmal anxiety",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/episodic-paroxysmal-anxiety"
      },
      {
        "slug": "esophageal-neoplasm",
        "name": "Esophageal tumor",
        "systems": [
          "abnormality-of-the-digestive-system",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/esophageal-neoplasm"
      },
      {
        "slug": "hyperhidrosis",
        "name": "Excessive sweating",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/hyperhidrosis"
      },
      {
        "slug": "extraadrenal-pheochromocytoma",
        "name": "Extraadrenal pheochromocytoma",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-nervous-system",
          "neoplasm"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/extraadrenal-pheochromocytoma"
      },
      {
        "slug": "syncope",
        "name": "Fainting spell",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/syncope"
      },
      {
        "slug": "fatigue",
        "name": "Fatigue",
        "systems": [
          "constitutional-symptom"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/fatigue"
      },
      {
        "slug": "flushing",
        "name": "Flushing",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/flushing"
      },
      {
        "slug": "gastrointestinal-hemorrhage",
        "name": "Gastrointestinal bleeding",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/gastrointestinal-hemorrhage"
      },
      {
        "slug": "gastrointestinal-stroma-tumor",
        "name": "Gastrointestinal stroma tumor",
        "systems": [
          "abnormality-of-the-digestive-system",
          "neoplasm"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/gastrointestinal-stroma-tumor"
      },
      {
        "slug": "neoplasm-of-the-gastrointestinal-tract",
        "name": "Gastrointestinal tract tumor",
        "systems": [
          "abnormality-of-the-digestive-system",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/neoplasm-of-the-gastrointestinal-tract"
      },
      {
        "slug": "glomerular-sclerosis",
        "name": "Glomerular sclerosis",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/glomerular-sclerosis"
      },
      {
        "slug": "glomus-jugular-tumor",
        "name": "Glomus jugular tumor",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-nervous-system",
          "neoplasm"
        ],
        "url": "https://dantelabs.com/traits/glomus-jugular-tumor"
      },
      {
        "slug": "headache",
        "name": "Headache",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/headache"
      },
      {
        "slug": "hearing-impairment",
        "name": "Hearing impairment",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hearing-impairment"
      },
      {
        "slug": "hypercalcemia",
        "name": "High blood calcium levels",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hypercalcemia"
      },
      {
        "slug": "hypertension",
        "name": "High blood pressure",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hypertension"
      },
      {
        "slug": "hyperglycemia",
        "name": "High blood sugar",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hyperglycemia"
      },
      {
        "slug": "proteinuria",
        "name": "High urine protein levels",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/proteinuria"
      },
      {
        "slug": "urticaria",
        "name": "Hives",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/urticaria"
      },
      {
        "slug": "hoarse-voice",
        "name": "Hoarse voice",
        "systems": [
          "abnormality-of-the-voice"
        ],
        "url": "https://dantelabs.com/traits/hoarse-voice"
      },
      {
        "slug": "hypertension-associated-with-pheochromocytoma",
        "name": "Hypertension associated with pheochromocytoma",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hypertension-associated-with-pheochromocytoma"
      },
      {
        "slug": "hypertensive-crisis",
        "name": "Hypertensive crisis",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hypertensive-crisis"
      },
      {
        "slug": "hypertensive-retinopathy",
        "name": "Hypertensive retinopathy",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-eye"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hypertensive-retinopathy"
      },
      {
        "slug": "vocal-cord-paralysis",
        "name": "Inability to move vocal cords",
        "systems": [
          "abnormality-of-the-nervous-system",
          "abnormality-of-the-voice"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/vocal-cord-paralysis"
      },
      {
        "slug": "dysphonia",
        "name": "Inability to produce voice sounds",
        "systems": [
          "abnormality-of-the-voice"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/dysphonia"
      },
      {
        "slug": "myocarditis",
        "name": "Inflammation of heart muscle",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/myocarditis"
      },
      {
        "slug": "episodic-abdominal-pain",
        "name": "Intermittent abdominal pain",
        "systems": [
          "abnormality-of-the-digestive-system",
          "constitutional-symptom"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/episodic-abdominal-pain"
      },
      {
        "slug": "intestinal-obstruction",
        "name": "Intestinal obstruction",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/intestinal-obstruction"
      },
      {
        "slug": "irregular-hyperpigmentation",
        "name": "Irregular hyperpigmentation",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/irregular-hyperpigmentation"
      },
      {
        "slug": "large-hands",
        "name": "Large hands",
        "systems": [
          "abnormality-of-limbs"
        ],
        "url": "https://dantelabs.com/traits/large-hands"
      },
      {
        "slug": "leiomyosarcoma",
        "name": "Leiomyosarcoma",
        "systems": [
          "neoplasm"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/leiomyosarcoma"
      },
      {
        "slug": "loss-of-voice",
        "name": "Loss of voice",
        "systems": [
          "abnormality-of-the-voice"
        ],
        "url": "https://dantelabs.com/traits/loss-of-voice"
      },
      {
        "slug": "anemia",
        "name": "Low number of red blood cells or hemoglobin",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/anemia"
      },
      {
        "slug": "pulmonary-infiltrates",
        "name": "Lung infiltrates",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/pulmonary-infiltrates"
      },
      {
        "slug": "nausea",
        "name": "Nausea",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/nausea"
      },
      {
        "slug": "nausea-and-vomiting",
        "name": "Nausea and vomiting",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/nausea-and-vomiting"
      },
      {
        "slug": "neurofibroma",
        "name": "Neurofibroma",
        "systems": [
          "abnormality-of-the-integument",
          "abnormality-of-the-nervous-system",
          "neoplasm"
        ],
        "url": "https://dantelabs.com/traits/neurofibroma"
      },
      {
        "slug": "pallor",
        "name": "Paleness",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/pallor"
      },
      {
        "slug": "palpitations",
        "name": "Palpitations",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/palpitations"
      },
      {
        "slug": "panic-attack",
        "name": "Panic attack",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/panic-attack"
      },
      {
        "slug": "paraganglioma",
        "name": "Paraganglioma",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-nervous-system",
          "neoplasm"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/paraganglioma"
      },
      {
        "slug": "paraganglioma-of-head-and-neck",
        "name": "Paraganglioma of head and neck",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-nervous-system",
          "neoplasm"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/paraganglioma-of-head-and-neck"
      },
      {
        "slug": "paroxysmal-vertigo",
        "name": "Paroxysmal vertigo",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/paroxysmal-vertigo"
      },
      {
        "slug": "hyperpigmentation-of-the-skin",
        "name": "Patchy darkened skin",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/hyperpigmentation-of-the-skin"
      },
      {
        "slug": "pheochromocytoma",
        "name": "Pheochromocytoma",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-nervous-system",
          "neoplasm"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/pheochromocytoma"
      },
      {
        "slug": "dysphagia",
        "name": "Poor swallowing",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/dysphagia"
      },
      {
        "slug": "positive-regitine-blocking-test",
        "name": "Positive regitine blocking test",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/positive-regitine-blocking-test"
      },
      {
        "slug": "pulsatile-tinnitus",
        "name": "Pulsatile tinnitus",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/pulsatile-tinnitus"
      },
      {
        "slug": "neoplasm-of-the-rectum",
        "name": "Rectal tumor",
        "systems": [
          "abnormality-of-the-digestive-system",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/neoplasm-of-the-rectum"
      },
      {
        "slug": "recurrent-paroxysmal-headache",
        "name": "Recurrent paroxysmal headache",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/recurrent-paroxysmal-headache"
      },
      {
        "slug": "renal-insufficiency",
        "name": "Renal failure",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/renal-insufficiency"
      },
      {
        "slug": "retinal-capillary-hemangioma",
        "name": "Retinal capillary hemangioma",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-eye",
          "abnormality-of-the-nervous-system",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/retinal-capillary-hemangioma"
      },
      {
        "slug": "tinnitus",
        "name": "Ringing in ears",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/tinnitus"
      },
      {
        "slug": "sinus-tachycardia",
        "name": "Sinus tachycardia",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/sinus-tachycardia"
      },
      {
        "slug": "skin-rash",
        "name": "Skin rash",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/skin-rash"
      },
      {
        "slug": "neoplasm-of-the-small-intestine",
        "name": "Small intestine tumor",
        "systems": [
          "abnormality-of-the-digestive-system",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/neoplasm-of-the-small-intestine"
      },
      {
        "slug": "episodic-hyperhidrosis",
        "name": "Sporadic excessive sweating",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/episodic-hyperhidrosis"
      },
      {
        "slug": "neoplasm-of-the-stomach",
        "name": "Stomach tumor",
        "systems": [
          "abnormality-of-the-digestive-system",
          "neoplasm"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/neoplasm-of-the-stomach"
      },
      {
        "slug": "lymphadenopathy",
        "name": "Swollen lymph nodes",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/lymphadenopathy"
      },
      {
        "slug": "mediastinal-lymphadenopathy",
        "name": "Swollen lymph nodes in center of chest",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-immune-system",
          "abnormality-of-the-thoracic-cavity"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/mediastinal-lymphadenopathy"
      },
      {
        "slug": "tremor",
        "name": "Tremor",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/tremor"
      },
      {
        "slug": "weight-loss",
        "name": "Weight loss",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/weight-loss"
      }
    ],
    "related": [
      {
        "slug": "sdhb",
        "symbol": "SDHB",
        "name": "succinate dehydrogenase complex iron sulfur subunit B",
        "shared": 3,
        "url": "https://dantelabs.com/genes/sdhb"
      },
      {
        "slug": "sdhd",
        "symbol": "SDHD",
        "name": "succinate dehydrogenase complex subunit D",
        "shared": 2,
        "url": "https://dantelabs.com/genes/sdhd"
      },
      {
        "slug": "kit",
        "symbol": "KIT",
        "name": "KIT proto-oncogene, receptor tyrosine kinase",
        "shared": 1,
        "url": "https://dantelabs.com/genes/kit"
      },
      {
        "slug": "max",
        "symbol": "MAX",
        "name": "MYC associated transcriptional regulator X",
        "shared": 1,
        "url": "https://dantelabs.com/genes/max"
      },
      {
        "slug": "pdgfra",
        "symbol": "PDGFRA",
        "name": "platelet derived growth factor receptor alpha",
        "shared": 1,
        "url": "https://dantelabs.com/genes/pdgfra"
      },
      {
        "slug": "sdha",
        "symbol": "SDHA",
        "name": "succinate dehydrogenase complex flavoprotein subunit A",
        "shared": 1,
        "url": "https://dantelabs.com/genes/sdha"
      },
      {
        "slug": "sdhaf2",
        "symbol": "SDHAF2",
        "name": "succinate dehydrogenase complex assembly factor 2",
        "shared": 1,
        "url": "https://dantelabs.com/genes/sdhaf2"
      },
      {
        "slug": "tmem127",
        "symbol": "TMEM127",
        "name": "transmembrane protein 127",
        "shared": 1,
        "url": "https://dantelabs.com/genes/tmem127"
      }
    ],
    "sources": {
      "bundleId": "2026.10.19-9814e911",
      "panel": "2026-10-19",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 29,
    "url": "https://dantelabs.com/genes/sdhc/variants",
    "items": [
      {
        "slug": "c-1a-g",
        "name": "c.1A>G",
        "commonName": null,
        "symbol": "SDHC",
        "classification": "pathogenic",
        "stars": 2,
        "hgvsC": null,
        "position": 161314406,
        "grch37Position": 161284196,
        "part": {
          "kind": "exon",
          "number": 1
        },
        "url": "https://dantelabs.com/genes/sdhc/variants/c-1a-g"
      },
      {
        "slug": "c-1a-t",
        "name": "c.1A>T",
        "commonName": null,
        "symbol": "SDHC",
        "classification": "pathogenic",
        "stars": 2,
        "hgvsC": null,
        "position": 161314406,
        "grch37Position": 161284196,
        "part": {
          "kind": "exon",
          "number": 1
        },
        "url": "https://dantelabs.com/genes/sdhc/variants/c-1a-t"
      },
      {
        "slug": "c-2t-g",
        "name": "c.2T>G",
        "commonName": null,
        "symbol": "SDHC",
        "classification": "pathogenic",
        "stars": 2,
        "hgvsC": null,
        "position": 161314407,
        "grch37Position": 161284197,
        "part": {
          "kind": "exon",
          "number": 1
        },
        "url": "https://dantelabs.com/genes/sdhc/variants/c-2t-g"
      },
      {
        "slug": "c-3g-a",
        "name": "c.3G>A",
        "commonName": "958G-A",
        "symbol": "SDHC",
        "classification": "pathogenic",
        "stars": 2,
        "hgvsC": null,
        "position": 161314408,
        "grch37Position": 161284198,
        "part": {
          "kind": "exon",
          "number": 1
        },
        "url": "https://dantelabs.com/genes/sdhc/variants/c-3g-a"
      },
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