{
  "url": "https://dantelabs.com/genes/rhd",
  "gene": {
    "slug": "rhd",
    "symbol": "RHD",
    "name": "Rh blood group D antigen",
    "hgnc": "HGNC:10009",
    "summary": null,
    "location": "1p36.11",
    "locusType": "gene with protein product",
    "aliases": [
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      "Rh4",
      "RhPI",
      "RhII",
      "DIIIc",
      "CD240D",
      "SLC42A5"
    ],
    "previousSymbols": [
      "RH"
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    "entrezId": 6007,
    "omim": [
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    "uniprot": [
      "Q02161"
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      "release": "v1.5",
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      "strand": "+",
      "ensemblTranscript": "ENST00000328664.9",
      "refseqTranscript": "NM_016124.6",
      "ensemblProtein": "ENSP00000331871.4",
      "refseqProtein": "NP_057208.3",
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    },
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      "build": "GRCh37",
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      "chrom": "1",
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      "end": 25656936,
      "strand": "+"
    },
    "neighbourhood": {
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      "genes": [
        {
          "symbol": "CLIC4",
          "ensemblId": "ENSG00000169504",
          "biotype": "protein_coding",
          "start": 24745342,
          "end": 24844324,
          "strand": "+",
          "slug": "clic4"
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        {
          "symbol": "RUNX3",
          "ensemblId": "ENSG00000020633",
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          "end": 24965121,
          "strand": "-",
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        {
          "symbol": "SYF2",
          "ensemblId": "ENSG00000117614",
          "biotype": "protein_coding",
          "start": 25220702,
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          "strand": "-",
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        },
        {
          "symbol": "RSRP1",
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          "biotype": "protein_coding",
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          "strand": "-",
          "slug": "rsrp1"
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        {
          "symbol": "TMEM50A",
          "ensemblId": "ENSG00000183726",
          "biotype": "protein_coding",
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          "strand": "+",
          "slug": "tmem50a"
        },
        {
          "symbol": "RHCE",
          "ensemblId": "ENSG00000188672",
          "biotype": "protein_coding",
          "start": 25362249,
          "end": 25430192,
          "strand": "-",
          "slug": "rhce"
        },
        {
          "symbol": "MACO1",
          "ensemblId": "ENSG00000204178",
          "biotype": "protein_coding",
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          "end": 25500209,
          "strand": "+",
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        },
        {
          "symbol": "LDLRAP1",
          "ensemblId": "ENSG00000157978",
          "biotype": "protein_coding",
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          "end": 25591296,
          "strand": "+",
          "slug": "ldlrap1"
        },
        {
          "symbol": "MAN1C1",
          "ensemblId": "ENSG00000117643",
          "biotype": "protein_coding",
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        },
        {
          "symbol": "SELENON",
          "ensemblId": "ENSG00000162430",
          "biotype": "protein_coding",
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          "end": 25818221,
          "strand": "+",
          "slug": "selenon"
        }
      ],
      "truncated": false
    },
    "reports": [],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "decreased-circulating-haptoglobin-concentration",
        "name": "Decreased circulating haptoglobin concentration",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/decreased-circulating-haptoglobin-concentration"
      },
      {
        "slug": "tachycardia",
        "name": "Elevated heart rate",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/tachycardia"
      },
      {
        "slug": "hepatomegaly",
        "name": "Enlarged liver",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "url": "https://dantelabs.com/traits/hepatomegaly"
      },
      {
        "slug": "hepatosplenomegaly",
        "name": "Enlarged liver and spleen",
        "systems": [
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          "abnormality-of-the-digestive-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hepatosplenomegaly"
      },
      {
        "slug": "fetal-ascites",
        "name": "Fetal ascites",
        "systems": [
          "abnormality-of-prenatal-development-or-birth",
          "abnormality-of-the-digestive-system"
        ],
        "url": "https://dantelabs.com/traits/fetal-ascites"
      },
      {
        "slug": "fetal-pericardial-effusion",
        "name": "Fetal pericardial effusion",
        "systems": [
          "abnormality-of-prenatal-development-or-birth",
          "abnormality-of-the-cardiovascular-system"
        ],
        "url": "https://dantelabs.com/traits/fetal-pericardial-effusion"
      },
      {
        "slug": "fetal-pleural-effusion",
        "name": "Fetal pleural effusion",
        "systems": [
          "abnormality-of-prenatal-development-or-birth"
        ],
        "url": "https://dantelabs.com/traits/fetal-pleural-effusion"
      },
      {
        "slug": "hemolytic-anemia",
        "name": "Hemolytic anemia",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/hemolytic-anemia"
      },
      {
        "slug": "hyperbilirubinemia",
        "name": "High blood bilirubin levels",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hyperbilirubinemia"
      },
      {
        "slug": "polyhydramnios",
        "name": "High levels of amniotic fluid",
        "systems": [
          "abnormality-of-prenatal-development-or-birth"
        ],
        "url": "https://dantelabs.com/traits/polyhydramnios"
      },
      {
        "slug": "hydrops-fetalis",
        "name": "Hydrops fetalis",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-prenatal-development-or-birth"
        ],
        "url": "https://dantelabs.com/traits/hydrops-fetalis"
      },
      {
        "slug": "hypochromia",
        "name": "Hypochromia",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hypochromia"
      },
      {
        "slug": "increased-circulating-lactate-dehydrogenase-concentration",
        "name": "Increased circulating lactate dehydrogenase concentration",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/increased-circulating-lactate-dehydrogenase-concentration"
      },
      {
        "slug": "reticulocytosis",
        "name": "Increased immature red blood cells",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/reticulocytosis"
      },
      {
        "slug": "increased-red-cell-osmotic-fragility",
        "name": "Increased red cell osmotic fragility",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/increased-red-cell-osmotic-fragility"
      },
      {
        "slug": "tachypnea",
        "name": "Increased respiratory rate or depth of breathing",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/tachypnea"
      },
      {
        "slug": "splenomegaly",
        "name": "Increased spleen size",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-immune-system"
        ],
        "url": "https://dantelabs.com/traits/splenomegaly"
      },
      {
        "slug": "jaundice",
        "name": "Jaundice",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/jaundice"
      },
      {
        "slug": "kernicterus",
        "name": "Kernicterus",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/kernicterus"
      },
      {
        "slug": "hypoxemia",
        "name": "Low blood oxygen level",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hypoxemia"
      },
      {
        "slug": "oligohydramnios",
        "name": "Low levels of amniotic fluid",
        "systems": [
          "abnormality-of-prenatal-development-or-birth"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/oligohydramnios"
      },
      {
        "slug": "macrocytic-anemia",
        "name": "Macrocytic anemia",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/macrocytic-anemia"
      },
      {
        "slug": "positive-direct-antiglobulin-test",
        "name": "Positive direct antiglobulin test",
        "systems": [
          "abnormality-of-the-immune-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/positive-direct-antiglobulin-test"
      },
      {
        "slug": "intrauterine-growth-retardation",
        "name": "Prenatal growth deficiency",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/intrauterine-growth-retardation"
      },
      {
        "slug": "spherocytosis",
        "name": "Spherocytosis",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/spherocytosis"
      },
      {
        "slug": "stomatocytosis",
        "name": "Stomatocytosis",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/stomatocytosis"
      },
      {
        "slug": "anisocytosis",
        "name": "Unequal size of red blood cells",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/anisocytosis"
      }
    ],
    "related": [],
    "sources": null,
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}