{
  "url": "https://dantelabs.com/genes/kcnq1ot1",
  "gene": {
    "slug": "kcnq1ot1",
    "symbol": "KCNQ1OT1",
    "name": "KCNQ1 opposite strand/antisense transcript 1",
    "hgnc": "HGNC:6295",
    "summary": null,
    "summaryProse": null,
    "references": {},
    "location": "11p15.5",
    "locusType": "RNA, long non-coding",
    "aliases": [
      "KvDMR1",
      "KCNQ1-AS2",
      "KvLQT1-AS",
      "LIT1",
      "NCRNA00012"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000269821",
    "entrezId": 10984,
    "omim": [
      "604115"
    ],
    "uniprot": [],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "11",
      "start": 2608328,
      "end": 2699994,
      "strand": "-",
      "ensemblTranscript": "ENST00000597346.1",
      "refseqTranscript": "NR_002728.4",
      "exons": [
        {
          "start": 2608328,
          "end": 2699994
        }
      ]
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "11",
      "start": 2629558,
      "end": 2721224,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 2154161,
      "end": 3154160,
      "genes": [
        {
          "symbol": "IGF2",
          "ensemblId": "ENSG00000167244",
          "biotype": "protein_coding",
          "start": 2129112,
          "end": 2158596,
          "strand": "-",
          "slug": "igf2"
        },
        {
          "symbol": "INS-IGF2",
          "ensemblId": "ENSG00000129965",
          "biotype": "protein_coding",
          "start": 2132538,
          "end": 2161209,
          "strand": "-",
          "slug": "ins-igf2"
        },
        {
          "symbol": "INS",
          "ensemblId": "ENSG00000254647",
          "biotype": "protein_coding",
          "start": 2159779,
          "end": 2161221,
          "strand": "-",
          "slug": "ins"
        },
        {
          "symbol": "TH",
          "ensemblId": "ENSG00000180176",
          "biotype": "protein_coding",
          "start": 2163929,
          "end": 2171968,
          "strand": "-",
          "slug": "th"
        },
        {
          "symbol": "ASCL2",
          "ensemblId": "ENSG00000183734",
          "biotype": "protein_coding",
          "start": 2268498,
          "end": 2271040,
          "strand": "-",
          "slug": "ascl2"
        },
        {
          "symbol": "C11orf21",
          "ensemblId": "ENSG00000110665",
          "biotype": "protein_coding",
          "start": 2295628,
          "end": 2303180,
          "strand": "-",
          "slug": "c11orf21"
        },
        {
          "symbol": "TSPAN32",
          "ensemblId": "ENSG00000064201",
          "biotype": "protein_coding",
          "start": 2301981,
          "end": 2318204,
          "strand": "+",
          "slug": "tspan32"
        },
        {
          "symbol": "CD81",
          "ensemblId": "ENSG00000110651",
          "biotype": "protein_coding",
          "start": 2376166,
          "end": 2398079,
          "strand": "+",
          "slug": "cd81"
        },
        {
          "symbol": "TSSC4",
          "ensemblId": "ENSG00000184281",
          "biotype": "protein_coding",
          "start": 2400488,
          "end": 2403878,
          "strand": "+",
          "slug": "tssc4"
        },
        {
          "symbol": "TRPM5",
          "ensemblId": "ENSG00000070985",
          "biotype": "protein_coding",
          "start": 2404515,
          "end": 2444519,
          "strand": "-",
          "slug": "trpm5"
        },
        {
          "symbol": "KCNQ1",
          "ensemblId": "ENSG00000053918",
          "biotype": "protein_coding",
          "start": 2444654,
          "end": 2849105,
          "strand": "+",
          "slug": "kcnq1"
        },
        {
          "symbol": "CDKN1C",
          "ensemblId": "ENSG00000129757",
          "biotype": "protein_coding",
          "start": 2883213,
          "end": 2885775,
          "strand": "-",
          "slug": "cdkn1c"
        },
        {
          "symbol": "SLC67A1",
          "ensemblId": "ENSG00000110628",
          "biotype": "protein_coding",
          "start": 2899718,
          "end": 2925247,
          "strand": "+",
          "slug": "slc67a1"
        },
        {
          "symbol": "PHLDA2",
          "ensemblId": "ENSG00000181649",
          "biotype": "protein_coding",
          "start": 2928273,
          "end": 2929593,
          "strand": "-",
          "slug": "phlda2"
        },
        {
          "symbol": "NAP1L4",
          "ensemblId": "ENSG00000205531",
          "biotype": "protein_coding",
          "start": 2944429,
          "end": 2992416,
          "strand": "-",
          "slug": "nap1l4"
        },
        {
          "symbol": "CARS1",
          "ensemblId": "ENSG00000110619",
          "biotype": "protein_coding",
          "start": 3000920,
          "end": 3057646,
          "strand": "-",
          "slug": "cars1"
        },
        {
          "symbol": "OSBPL5",
          "ensemblId": "ENSG00000021762",
          "biotype": "protein_coding",
          "start": 3087107,
          "end": 3166739,
          "strand": "-",
          "slug": "osbpl5"
        }
      ],
      "truncated": false
    },
    "reports": [],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abnormal-cardiovascular-system-morphology",
        "name": "Abnormal cardiovascular system morphology",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormal-cardiovascular-system-morphology"
      },
      {
        "slug": "abnormality-of-the-dentition",
        "name": "Abnormal dentition",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormality-of-the-dentition"
      },
      {
        "slug": "macroglossia",
        "name": "Abnormally large tongue",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/macroglossia"
      },
      {
        "slug": "adrenocortical-carcinoma",
        "name": "Adrenocortical carcinoma",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "neoplasm"
        ],
        "url": "https://dantelabs.com/traits/adrenocortical-carcinoma"
      },
      {
        "slug": "adrenocortical-cytomegaly",
        "name": "Adrenocortical cytomegaly",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "url": "https://dantelabs.com/traits/adrenocortical-cytomegaly"
      },
      {
        "slug": "accelerated-skeletal-maturation",
        "name": "Advanced bone age",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/accelerated-skeletal-maturation"
      },
      {
        "slug": "asymmetry-of-the-thorax",
        "name": "Asymmetric chest",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/asymmetry-of-the-thorax"
      },
      {
        "slug": "hemihypertrophy",
        "name": "Asymmetric overgrowth",
        "systems": [
          "abnormality-of-limbs",
          "growth-abnormality"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/hemihypertrophy"
      },
      {
        "slug": "proptosis",
        "name": "Bulging eye",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "url": "https://dantelabs.com/traits/proptosis"
      },
      {
        "slug": "coarse-facial-features",
        "name": "Coarse facial features",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "url": "https://dantelabs.com/traits/coarse-facial-features"
      },
      {
        "slug": "dandy-walker-malformation",
        "name": "Dandy-Walker malformation",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/dandy-walker-malformation"
      },
      {
        "slug": "cardiomyopathy",
        "name": "Disease of the heart muscle",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "url": "https://dantelabs.com/traits/cardiomyopathy"
      },
      {
        "slug": "cardiomegaly",
        "name": "Enlarged heart",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "url": "https://dantelabs.com/traits/cardiomegaly"
      },
      {
        "slug": "enlarged-kidney",
        "name": "Enlarged kidney",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/enlarged-kidney"
      },
      {
        "slug": "hepatomegaly",
        "name": "Enlarged liver",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "url": "https://dantelabs.com/traits/hepatomegaly"
      },
      {
        "slug": "facial-asymmetry",
        "name": "Facial asymmetry",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/facial-asymmetry"
      },
      {
        "slug": "diastasis-recti",
        "name": "Gap between large left and right abdominal muscles",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/diastasis-recti"
      },
      {
        "slug": "overgrowth",
        "name": "General overgrowth",
        "systems": [
          "growth-abnormality"
        ],
        "url": "https://dantelabs.com/traits/overgrowth"
      },
      {
        "slug": "gonadoblastoma",
        "name": "Gonadoblastoma",
        "systems": [
          "abnormality-of-the-genitourinary-system",
          "neoplasm"
        ],
        "url": "https://dantelabs.com/traits/gonadoblastoma"
      },
      {
        "slug": "hepatoblastoma",
        "name": "Hepatoblastoma",
        "systems": [
          "abnormality-of-the-digestive-system",
          "neoplasm"
        ],
        "url": "https://dantelabs.com/traits/hepatoblastoma"
      },
      {
        "slug": "impaired-pain-sensation",
        "name": "Impaired pain sensation",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/impaired-pain-sensation"
      },
      {
        "slug": "nephrocalcinosis",
        "name": "Increased calcium level in kidney",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/nephrocalcinosis"
      },
      {
        "slug": "posterior-helix-pit",
        "name": "Indentation in back of outer ear",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "url": "https://dantelabs.com/traits/posterior-helix-pit"
      },
      {
        "slug": "inguinal-hernia",
        "name": "Inguinal hernia",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/inguinal-hernia"
      },
      {
        "slug": "mild-intellectual-disability",
        "name": "Intellectual disability, mild",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/mild-intellectual-disability"
      },
      {
        "slug": "kidney-stone",
        "name": "Kidney stone",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/kidney-stone"
      },
      {
        "slug": "neonatal-hypoglycemia",
        "name": "Low blood sugar in newborn",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "url": "https://dantelabs.com/traits/neonatal-hypoglycemia"
      },
      {
        "slug": "midface-retrusion",
        "name": "Midface retrusion",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "url": "https://dantelabs.com/traits/midface-retrusion"
      },
      {
        "slug": "myelomeningocele",
        "name": "Myelomeningocele",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/myelomeningocele"
      },
      {
        "slug": "nephroblastoma",
        "name": "Nephroblastoma",
        "systems": [
          "abnormality-of-the-genitourinary-system",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/nephroblastoma"
      },
      {
        "slug": "omphalocele",
        "name": "Omphalocele",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/omphalocele"
      },
      {
        "slug": "overgrowth-of-external-genitalia",
        "name": "Overgrowth of external genitalia",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/overgrowth-of-external-genitalia"
      },
      {
        "slug": "pancreatic-hyperplasia",
        "name": "Pancreatic hyperplasia",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "url": "https://dantelabs.com/traits/pancreatic-hyperplasia"
      },
      {
        "slug": "placental-mesenchymal-dysplasia",
        "name": "Placental mesenchymal dysplasia",
        "systems": [
          "abnormality-of-prenatal-development-or-birth"
        ],
        "url": "https://dantelabs.com/traits/placental-mesenchymal-dysplasia"
      },
      {
        "slug": "nevus-flammeus",
        "name": "port-wine stain",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/nevus-flammeus"
      },
      {
        "slug": "prominent-occiput",
        "name": "Prominent back of the head",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/prominent-occiput"
      },
      {
        "slug": "prominent-metopic-ridge",
        "name": "Prominent metopic ridge",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/prominent-metopic-ridge"
      },
      {
        "slug": "renal-cortical-cysts",
        "name": "Renal cortical cysts",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/renal-cortical-cysts"
      },
      {
        "slug": "scoliosis",
        "name": "Scoliosis",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/scoliosis"
      },
      {
        "slug": "cryptorchidism",
        "name": "Undescended testes",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/cryptorchidism"
      },
      {
        "slug": "vesicoureteral-reflux",
        "name": "Vesicoureteral reflux",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/vesicoureteral-reflux"
      },
      {
        "slug": "large-fontanelles",
        "name": "Wide fontanelles",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/large-fontanelles"
      }
    ],
    "related": [],
    "sources": null,
    "locusKind": "lncRna"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}