{
  "url": "https://dantelabs.com/genes/igsf1",
  "gene": {
    "slug": "igsf1",
    "symbol": "IGSF1",
    "name": "immunoglobulin superfamily member 1",
    "hgnc": "HGNC:5948",
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    "location": "Xq26.1",
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    "aliases": [
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      "IGDC1",
      "IGCD1",
      "INHBP",
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      "PGSF2"
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    "previousSymbols": [],
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    "entrezId": 3547,
    "omim": [
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    "uniprot": [
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      "release": "v1.5",
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      "ensemblTranscript": "ENST00000361420.8",
      "refseqTranscript": "NM_001555.5",
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    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "X",
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      "strand": "-"
    },
    "neighbourhood": {
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      "genes": [
        {
          "symbol": "ENOX2",
          "ensemblId": "ENSG00000165675",
          "biotype": "protein_coding",
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          "slug": "enox2"
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        {
          "symbol": "ARHGAP36",
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          "strand": "+",
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        },
        {
          "symbol": "OR13H1",
          "ensemblId": "ENSG00000171054",
          "biotype": "protein_coding",
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          "strand": "+",
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      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "congenital-hypothyroidism",
        "name": "Congenital Hypothyroidism",
        "diseases": [
          {
            "mondoId": "MONDO:0018612",
            "name": "Congenital Hypothyroidism",
            "genes": 18,
            "inheritance": null,
            "description": "A thyroid hormone deficiency present from birth.",
            "management": null,
            "evidence": {
              "gencc": [
                "Ambry Genetics",
                "G2P",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
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              "acmgSf": false,
              "inheritance": []
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            "sameAsReport": true,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/conditions/congenital-hypothyroidism"
      },
      {
        "slug": "thyroid-cancer-report",
        "name": "Thyroid Cancer",
        "diseases": [
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            "mondoId": "MONDO:0005420",
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            "inheritance": null,
            "description": "Abnormally low levels of thyroid hormone.",
            "management": null,
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              "acmgSf": false,
              "inheritance": []
            },
            "sameAsReport": false,
            "broad": false
          },
          {
            "mondoId": "MONDO:0003240",
            "name": "Thyroid Gland Disorder",
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            "inheritance": null,
            "description": "A disease involving the thyroid gland.",
            "management": null,
            "evidence": {
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                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": []
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/conditions/thyroid-cancer-report"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "inappropriately-normal-thyroid-stimulating-hormone-level",
        "name": "Inappropriately normal thyroid-stimulating hormone level",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/inappropriately-normal-thyroid-stimulating-hormone-level"
      },
      {
        "slug": "overweight",
        "name": "Overweight",
        "systems": [
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        ],
        "url": "https://dantelabs.com/traits/overweight"
      },
      {
        "slug": "reduced-circulating-prolactin-concentration",
        "name": "Reduced circulating prolactin concentration",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/reduced-circulating-prolactin-concentration"
      },
      {
        "slug": "reduced-tsh-response-to-thyrotrophin-releasing-hormone-stimulation-test",
        "name": "Reduced TSH response to thyrotrophin-releasing hormone stimulation test",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "url": "https://dantelabs.com/traits/reduced-tsh-response-to-thyrotrophin-releasing-hormone-stimulation-test"
      },
      {
        "slug": "hypothyroidism",
        "name": "Underactive thyroid",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hypothyroidism"
      }
    ],
    "related": [
      {
        "slug": "duox2",
        "symbol": "DUOX2",
        "name": "dual oxidase 2",
        "shared": 3,
        "url": "https://dantelabs.com/genes/duox2"
      },
      {
        "slug": "duoxa2",
        "symbol": "DUOXA2",
        "name": "dual oxidase maturation factor 2",
        "shared": 3,
        "url": "https://dantelabs.com/genes/duoxa2"
      },
      {
        "slug": "irs4",
        "symbol": "IRS4",
        "name": "insulin receptor substrate 4",
        "shared": 3,
        "url": "https://dantelabs.com/genes/irs4"
      },
      {
        "slug": "iyd",
        "symbol": "IYD",
        "name": "iodotyrosine deiodinase",
        "shared": 3,
        "url": "https://dantelabs.com/genes/iyd"
      },
      {
        "slug": "nkx2-5",
        "symbol": "NKX2-5",
        "name": "NK2 homeobox 5",
        "shared": 3,
        "url": "https://dantelabs.com/genes/nkx2-5"
      },
      {
        "slug": "pax8",
        "symbol": "PAX8",
        "name": "paired box 8",
        "shared": 3,
        "url": "https://dantelabs.com/genes/pax8"
      },
      {
        "slug": "secisbp2",
        "symbol": "SECISBP2",
        "name": "SECIS binding protein 2",
        "shared": 3,
        "url": "https://dantelabs.com/genes/secisbp2"
      },
      {
        "slug": "slc26a4",
        "symbol": "SLC26A4",
        "name": "solute carrier family 26 member 4",
        "shared": 3,
        "url": "https://dantelabs.com/genes/slc26a4"
      },
      {
        "slug": "slc26a7",
        "symbol": "SLC26A7",
        "name": "solute carrier family 26 member 7",
        "shared": 3,
        "url": "https://dantelabs.com/genes/slc26a7"
      },
      {
        "slug": "slc5a5",
        "symbol": "SLC5A5",
        "name": "solute carrier family 5 member 5",
        "shared": 3,
        "url": "https://dantelabs.com/genes/slc5a5"
      },
      {
        "slug": "tbl1x",
        "symbol": "TBL1X",
        "name": "transducin beta like 1 X-linked",
        "shared": 3,
        "url": "https://dantelabs.com/genes/tbl1x"
      },
      {
        "slug": "tg",
        "symbol": "TG",
        "name": "thyroglobulin",
        "shared": 3,
        "url": "https://dantelabs.com/genes/tg"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}