--- title: "GLA D155E (c.465T>A, rs782197072) | Dante Labs" description: "ClinVar classifies GLA D155E as Likely pathogenic (criteria provided, multiple submitters, no conflicts). Where it sits in the genome, its predicted effect, and the Genome Test reports that look at it." url: "https://dantelabs.com/genes/gla/variants/d155e" --- 1. [Genes](https://dantelabs.com/genes) 2. [GLA](https://dantelabs.com/genes/gla) 3. GLA D155E Variant # GLA D155E NM_000169.3(GLA):c.465T>A (p.Asp155Glu) Also known as - p.Asp155Glu - p.D155E - rs782197072 * ClinVar classification Likely pathogenic * Review status 2 stars out of 4 criteria provided, multiple submitters, no conflicts * Last evaluated 8 September 2026 Data current to ClinVar release 2026-10-12 · Dante Labs data release 2026.10.16-c6eea6bf Facts last changed 16 October 2026 ## Summary D155E is a missense variant in GLA: it changes a single amino acid in the protein the gene encodes. ClinVar classifies it as likely pathogenic for Fabry Disease (criteria provided, multiple submitters, no conflicts). ## ClinVar classifications | Condition | Classification | Review status | Submissions | Last evaluated | | -------------------------------------------------------------------------------------------------------------------------------------------------------------------- | ----------------- | --------------------------------------------------------------------- | ------------- | ---------------- | | [Fabry Disease](https://dantelabs.com/conditions/fabry-disease) [ClinVar VCV003385332 (opens in a new tab)](https://www.ncbi.nlm.nih.gov/clinvar/variation/3385332/) | Likely pathogenic | 2 stars out of 4 criteria provided, multiple submitters, no conflicts | 2 submissions | 8 September 2026 | Classifications as ClinVar records them in release 2026-10-12. ClinVar updates them as evidence is reviewed. ## Where it lies in GLA D155E lies in exon 3 of the 7 in GLA's MANE Select transcript, NM_000169.3. [GLA variants in exon 3 →](https://dantelabs.com/genes/gla/variants?exon=3) [GLA's gene diagram →](https://dantelabs.com/genes/gla#gene-structure) ## Molecular details | Gene | [GLA](https://dantelabs.com/genes/gla) | | --------------------------- | -------------------------------------------------------------------------------------------- | | Transcript | NM_000169.3 MANE Select | | Coding DNA change (HGVS c.) | c.465T>A | | Protein change (HGVS p.) | p.Asp155Glu p.D155E | | Predicted consequence | Missense [missense_variant (opens in a new tab)](https://purl.obolibrary.org/obo/SO_0001583) | | Predicted impact | Moderate | | Position (GRCh38) | chrX:101401714 A>T | | Position (GRCh37) | chrX:100656702 A>T | | dbSNP ID | [rs782197072 (opens in a new tab)](https://www.ncbi.nlm.nih.gov/snp/rs782197072) | | ClinVar Variation ID | [VCV003385332 (opens in a new tab)](https://www.ncbi.nlm.nih.gov/clinvar/variation/3385332/) | | ClinVar Allele ID | 3544473 | | ClinVar name | NM_000169.3(GLA):c.465T>A (p.Asp155Glu) | ## GLA D155E in other databases - [ClinVar VCV003385332 (opens in a new tab)](https://www.ncbi.nlm.nih.gov/clinvar/variation/3385332/) - [dbSNP rs782197072 (opens in a new tab)](https://www.ncbi.nlm.nih.gov/snp/rs782197072) - [gnomAD X-101401714-A-T (opens in a new tab)](https://gnomad.broadinstitute.org/variant/X-101401714-A-T?dataset=gnomad_r4) - [Ensembl rs782197072 (opens in a new tab)](https://www.ensembl.org/Homo_sapiens/Variation/Explore?v=rs782197072) ## Reports that look at this variant (2) These Genome Test condition reports include D155E among the variants they look at. | Report | Conditions | Inheritance | | --------------------------------------------------------------------------------------- | ------------------------------------------------------- | ------------------ | | [Fabry Disease](https://dantelabs.com/conditions/fabry-disease) | Fabry Disease | X-linked recessive | | [Lysosomal Storage Disease](https://dantelabs.com/conditions/lysosomal-storage-disease) | Lysosomal storage disease (other and unspecified types) | | ## Other variants in GLA - [A15E Pathogenic 2 stars out of 4](https://dantelabs.com/genes/gla/variants/a15e) - [A20D Pathogenic/likely pathogenic 2 stars out of 4](https://dantelabs.com/genes/gla/variants/a20d) - [A20Gfs\*2 Pathogenic 2 stars out of 4](https://dantelabs.com/genes/gla/variants/a20gfs2) - [A29Gfs\*2 Pathogenic 2 stars out of 4](https://dantelabs.com/genes/gla/variants/a29gfs2) - [A31V Likely pathogenic 2 stars out of 4](https://dantelabs.com/genes/gla/variants/a31v) - [A37P Pathogenic/likely pathogenic 2 stars out of 4](https://dantelabs.com/genes/gla/variants/a37p) - [A37T Likely pathogenic 2 stars out of 4](https://dantelabs.com/genes/gla/variants/a37t) - [A97V Pathogenic/likely pathogenic 2 stars out of 4](https://dantelabs.com/genes/gla/variants/a97v) - [A121P Likely pathogenic 2 stars out of 4](https://dantelabs.com/genes/gla/variants/a121p) - [A135V Pathogenic 2 stars out of 4](https://dantelabs.com/genes/gla/variants/a135v) [All GLA variants](https://dantelabs.com/genes/gla/variants) ## Limitations This page describes publicly available information about a genetic variant. It is not a diagnosis, and it says nothing about whether you or anyone else carries this variant. Classifications come from ClinVar and change as new evidence is reviewed. A classification here may differ from the one in ClinVar today, or from the one a laboratory reports. Whole genome sequencing with short reads can miss or miscall some variants, particularly in repeated or highly similar stretches of DNA and in large insertions, deletions or rearrangements. If you have questions about a variant in your own results or in your family, talk to a genetic counsellor or your doctor. ## Sources & credits - Classifications from ClinVar (release 2026-10-12), National Center for Biotechnology Information. - Condition terms from the Mondo Disease Ontology (release 2026-10-06), used under CC BY 4.0. - Gene symbols and names from the HUGO Gene Nomenclature Committee (release 2026-10-16). - Allele identifiers from the ClinGen Allele Registry (release 2026-10-16-c4908f54). - Reference SNP identifiers from dbSNP (release b157), National Center for Biotechnology Information. - Gene–disease links from the Gene Curation Coalition, GenCC (release 2026-10-16). - Difficult regions from the Genome in a Bottle Consortium (release v3.6). - Transcripts from MANE (release v1.5), NCBI and EMBL-EBI. - Predicted consequences from mehari (release 0.11.0), with transcript models from cdot. - Built from Dante Labs data release 2026.10.16-c6eea6bf of 16 October 2026. ## Cite this page APA > Dante Labs. (16 October 2026). GLA D155E (c.465T>A, rs782197072) (Version 2026.10.16-c6eea6bf). Retrieved 17 October 2026, from https\://dantelabs.com/genes/gla/variants/d155e Vancouver > Dante Labs. GLA D155E (c.465T>A, rs782197072) \[Internet]. Version 2026.10.16-c6eea6bf. 16 October 2026 \[cited 17 October 2026]. Available from: https\://dantelabs.com/genes/gla/variants/d155e Download citation [RIS](https://dantelabs.com/genes/gla/variants/d155e/cite.ris) [BibTeX](https://dantelabs.com/genes/gla/variants/d155e/cite.bib) [CSL-JSON](https://dantelabs.com/genes/gla/variants/d155e/cite.json) ## Read your whole genome From $449 Free shipping · Results in 6–8 weeks [Explore the Genome Test](https://dantelabs.com/whole-genome-sequencing)