--- title: "FLNC G2011R (c.6031G>A, rs1554400962) | Dante Labs" description: "ClinVar classifies FLNC G2011R as Pathogenic/likely pathogenic (criteria provided, multiple submitters, no conflicts). Where it sits in the genome, its predicted effect, and the Genome Test reports that look at it." url: "https://dantelabs.com/genes/flnc/variants/g2011r" --- 1. [Genes](https://dantelabs.com/genes) 2. [FLNC](https://dantelabs.com/genes/flnc) 3. FLNC G2011R Variant # FLNC G2011R NM_001458.5(FLNC):c.6031G>A (p.Gly2011Arg) Also known as - p.Gly2011Arg - p.G2011R - rs1554400962 * ClinVar classification Pathogenic/likely pathogenic * Review status 2 stars out of 4 criteria provided, multiple submitters, no conflicts * Last evaluated 14 July 2025 Data current to ClinVar release 2026-10-12 · Dante Labs data release 2026.10.16-c6eea6bf Facts last changed 16 October 2026 ## Summary G2011R is a missense variant in FLNC: it changes a single amino acid in the protein the gene encodes. ClinVar classifies it as pathogenic or likely pathogenic for hypertrophic cardiomyopathy 26 (criteria provided, multiple submitters, no conflicts). ## ClinVar classifications | Condition | Classification | Review status | Submissions | Last evaluated | | --------------------------------------------------------------------------------------------------------------------------------- | ---------------------------- | --------------------------------------------------------------------- | ------------- | -------------- | | hypertrophic cardiomyopathy 26[ClinVar VCV000472122 (opens in a new tab)](https://www.ncbi.nlm.nih.gov/clinvar/variation/472122/) | Pathogenic/likely pathogenic | 2 stars out of 4 criteria provided, multiple submitters, no conflicts | 3 submissions | 14 July 2025 | Classifications as ClinVar records them in release 2026-10-12. ClinVar updates them as evidence is reviewed. ## Molecular details | Gene | [FLNC](https://dantelabs.com/genes/flnc) | | --------------------------- | ----------------------------------------------------------------------------------------------------------------------------------------------------- | | Transcript | NM_001458.5 MANE Select | | Coding DNA change (HGVS c.) | c.6031G>A | | Protein change (HGVS p.) | p.Gly2011Arg p.G2011R | | Predicted consequence | Missense [missense_variant (opens in a new tab)](https://purl.obolibrary.org/obo/SO_0001583) | | Predicted impact | Moderate | | Position (GRCh38) | chr7:128852854 G>A | | Position (GRCh37) | chr7:128492908 G>A | | dbSNP ID | [rs1554400962 (opens in a new tab)](https://www.ncbi.nlm.nih.gov/snp/rs1554400962) | | ClinVar Variation ID | [VCV000472122 (opens in a new tab)](https://www.ncbi.nlm.nih.gov/clinvar/variation/472122/) | | ClinVar Allele ID | 457357 | | ClinGen Allele Registry ID | [CA369210984 (opens in a new tab)](https://reg.clinicalgenome.org/redmine/projects/registry/genboree_registry/by_canonicalid?canonicalid=CA369210984) | | ClinVar name | NM_001458.5(FLNC):c.6031G>A (p.Gly2011Arg) | ## FLNC G2011R in other databases - [ClinVar VCV000472122 (opens in a new tab)](https://www.ncbi.nlm.nih.gov/clinvar/variation/472122/) - [dbSNP rs1554400962 (opens in a new tab)](https://www.ncbi.nlm.nih.gov/snp/rs1554400962) - [ClinGen Allele Registry CA369210984 (opens in a new tab)](https://reg.clinicalgenome.org/redmine/projects/registry/genboree_registry/by_canonicalid?canonicalid=CA369210984) - [gnomAD 7-128852854-G-A (opens in a new tab)](https://gnomad.broadinstitute.org/variant/7-128852854-G-A?dataset=gnomad_r4) - [Ensembl rs1554400962 (opens in a new tab)](https://www.ensembl.org/Homo_sapiens/Variation/Explore?v=rs1554400962) ## Reports that look at this variant (1) These Genome Test condition reports include G2011R among the variants they look at. | Report | Conditions | Inheritance | | ------------------------------------------------------------------------------------------- | --------------------------- | ------------------ | | [Hypertrophic Cardiomyopathy](https://dantelabs.com/conditions/hypertrophic-cardiomyopathy) | Hypertrophic Cardiomyopathy | Autosomal dominant | ## Other variants in FLNC - [A193T Pathogenic 2 stars out of 4](https://dantelabs.com/genes/flnc/variants/a193t) - [A1186V Pathogenic 2 stars out of 4](https://dantelabs.com/genes/flnc/variants/a1186v) - [c.970-4A>G Pathogenic 2 stars out of 4](https://dantelabs.com/genes/flnc/variants/c-970-4a-g) - [c.2550+2T>C Pathogenic/likely pathogenic 2 stars out of 4](https://dantelabs.com/genes/flnc/variants/c-2550plus2t-c) - [c.3193-2A>G Likely pathogenic 2 stars out of 4](https://dantelabs.com/genes/flnc/variants/c-3193-2a-g) - [c.3791-1G>C Pathogenic/likely pathogenic 2 stars out of 4](https://dantelabs.com/genes/flnc/variants/c-3791-1g-c) - [c.5199+1G>T Pathogenic/likely pathogenic 2 stars out of 4](https://dantelabs.com/genes/flnc/variants/c-5199plus1g-t) - [c.6727+1G>A Likely pathogenic 2 stars out of 4](https://dantelabs.com/genes/flnc/variants/c-6727plus1g-a) - [D1061Ifs\*17 Pathogenic 2 stars out of 4](https://dantelabs.com/genes/flnc/variants/d1061ifs17) - [F298Wfs\*48 Pathogenic/likely pathogenic 2 stars out of 4](https://dantelabs.com/genes/flnc/variants/f298wfs48) [All FLNC variants](https://dantelabs.com/genes/flnc/variants) ## Limitations This page describes publicly available information about a genetic variant. It is not a diagnosis, and it says nothing about whether you or anyone else carries this variant. Classifications come from ClinVar and change as new evidence is reviewed. A classification here may differ from the one in ClinVar today, or from the one a laboratory reports. Whole genome sequencing with short reads can miss or miscall some variants, particularly in repeated or highly similar stretches of DNA and in large insertions, deletions or rearrangements. If you have questions about a variant in your own results or in your family, talk to a genetic counsellor or your doctor. ## Sources & credits - Classifications from ClinVar (release 2026-10-12), National Center for Biotechnology Information. - Condition terms from the Mondo Disease Ontology (release 2026-10-06), used under CC BY 4.0. - Gene symbols and names from the HUGO Gene Nomenclature Committee (release 2026-10-16). - Allele identifiers from the ClinGen Allele Registry (release 2026-10-16-c4908f54). - Reference SNP identifiers from dbSNP (release b157), National Center for Biotechnology Information. - Gene–disease links from the Gene Curation Coalition, GenCC (release 2026-10-16). - Difficult regions from the Genome in a Bottle Consortium (release v3.6). - Transcripts from MANE (release v1.5), NCBI and EMBL-EBI. - Predicted consequences from mehari (release 0.11.0), with transcript models from cdot. - Built from Dante Labs data release 2026.10.16-c6eea6bf of 16 October 2026. ## Cite this page APA > Dante Labs. (16 October 2026). FLNC G2011R (c.6031G>A, rs1554400962) (Version 2026.10.16-c6eea6bf). Retrieved 17 October 2026, from https\://dantelabs.com/genes/flnc/variants/g2011r Vancouver > Dante Labs. FLNC G2011R (c.6031G>A, rs1554400962) \[Internet]. Version 2026.10.16-c6eea6bf. 16 October 2026 \[cited 17 October 2026]. Available from: https\://dantelabs.com/genes/flnc/variants/g2011r Download citation [RIS](https://dantelabs.com/genes/flnc/variants/g2011r/cite.ris) [BibTeX](https://dantelabs.com/genes/flnc/variants/g2011r/cite.bib) [CSL-JSON](https://dantelabs.com/genes/flnc/variants/g2011r/cite.json) ## Read your whole genome From $449 Free shipping · Results in 6–8 weeks [Explore the Genome Test](https://dantelabs.com/whole-genome-sequencing)