{
  "url": "https://dantelabs.com/genes/cyp2c19",
  "gene": {
    "slug": "cyp2c19",
    "symbol": "CYP2C19",
    "name": "cytochrome P450 family 2 subfamily C member 19",
    "hgnc": "HGNC:2621",
    "summary": null,
    "location": "10q23.33",
    "locusType": "gene with protein product",
    "aliases": [
      "P450IIC19",
      "CPCJ"
    ],
    "previousSymbols": [
      "CYP2C"
    ],
    "ensemblId": "ENSG00000165841",
    "entrezId": 1557,
    "omim": [
      "124020"
    ],
    "uniprot": [
      "P33261"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "10",
      "start": 94762681,
      "end": 94855547,
      "strand": "+",
      "ensemblTranscript": "ENST00000371321.9",
      "refseqTranscript": "NM_000769.4",
      "ensemblProtein": "ENSP00000360372.3",
      "refseqProtein": "NP_000760.1",
      "exons": [
        {
          "start": 94762681,
          "end": 94762873
        },
        {
          "start": 94775058,
          "end": 94775220
        },
        {
          "start": 94775390,
          "end": 94775539
        },
        {
          "start": 94780499,
          "end": 94780659
        },
        {
          "start": 94781821,
          "end": 94781997
        },
        {
          "start": 94820496,
          "end": 94820637
        },
        {
          "start": 94842837,
          "end": 94843024
        },
        {
          "start": 94849917,
          "end": 94850058
        },
        {
          "start": 94852733,
          "end": 94855547
        }
      ],
      "cds": {
        "start": 94762706,
        "end": 94852914
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "10",
      "start": 96447911,
      "end": 96613017,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
      "start": 94309114,
      "end": 95309113,
      "genes": [
        {
          "symbol": "PLCE1",
          "ensemblId": "ENSG00000138193",
          "biotype": "protein_coding",
          "start": 93993807,
          "end": 94332823,
          "strand": "+",
          "slug": "plce1"
        },
        {
          "symbol": "NOC3L",
          "ensemblId": "ENSG00000173145",
          "biotype": "protein_coding",
          "start": 94320340,
          "end": 94362982,
          "strand": "-",
          "slug": "noc3l"
        },
        {
          "symbol": "TBC1D12",
          "ensemblId": "ENSG00000108239",
          "biotype": "protein_coding",
          "start": 94402377,
          "end": 94537452,
          "strand": "+",
          "slug": "tbc1d12"
        },
        {
          "symbol": "HELLS",
          "ensemblId": "ENSG00000119969",
          "biotype": "protein_coding",
          "start": 94545329,
          "end": 94613905,
          "strand": "+",
          "slug": "hells"
        },
        {
          "symbol": "CYP2C18",
          "ensemblId": "ENSG00000108242",
          "biotype": "protein_coding",
          "start": 94682860,
          "end": 94736241,
          "strand": "+",
          "slug": "cyp2c18"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000276490",
          "biotype": "protein_coding",
          "start": 94688154,
          "end": 94853073,
          "strand": "+"
        },
        {
          "symbol": "CYP2C9",
          "ensemblId": "ENSG00000138109",
          "biotype": "protein_coding",
          "start": 94938544,
          "end": 94990149,
          "strand": "+",
          "slug": "cyp2c9"
        },
        {
          "symbol": "CYP2C8",
          "ensemblId": "ENSG00000138115",
          "biotype": "protein_coding",
          "start": 95034359,
          "end": 95069603,
          "strand": "-",
          "slug": "cyp2c8"
        },
        {
          "symbol": "ACSM6",
          "ensemblId": "ENSG00000173124",
          "biotype": "protein_coding",
          "start": 95194200,
          "end": 95228929,
          "strand": "+",
          "slug": "acsm6"
        },
        {
          "symbol": "PDLIM1",
          "ensemblId": "ENSG00000107438",
          "biotype": "protein_coding",
          "start": 95237569,
          "end": 95291126,
          "strand": "-",
          "slug": "pdlim1"
        }
      ],
      "truncated": false
    },
    "reports": [],
    "pharmacogenomics": [
      {
        "slug": "pharmacogenomics",
        "title": "Antidepressant, stomach-acid & clopidogrel response",
        "summary": "CYP2C19 clears several common antidepressants (citalopram, escitalopram, sertraline and some tricyclics), the proton-pump inhibitors used for reflux and ulcers, and the antifungal voriconazole — and it activates the antiplatelet clopidogrel into its working form. Activity ranges from poor to ultrarapid depending on which alleles you carry.",
        "actionable": [
          "Most relevant if you are prescribed clopidogrel after a stent, heart attack, or stroke — poor metabolisers may get little protection from it.",
          "If you start citalopram, escitalopram or sertraline, this result can guide the starting dose, and can help explain side effects or a weak response.",
          "Omeprazole, lansoprazole and pantoprazole may work less well in rapid and ultrarapid metabolisers; poor metabolisers on long-term treatment may manage on a lower dose.",
          "Also relevant to voriconazole, amitriptyline and other tricyclic antidepressants, and the anti-seizure drug clobazam."
        ],
        "caveat": "Calls the common *2, *3, *4 and *17 alleles. CYP2C19 lacks the copy-number complexity of CYP2D6, so common-allele calling is well supported — but rare alleles are not assessed.",
        "alleles": [
          {
            "name": "*4",
            "function": "No function",
            "reference": false
          },
          {
            "name": "*1",
            "function": "Normal function",
            "reference": true
          },
          {
            "name": "*17",
            "function": "Increased function",
            "reference": false
          },
          {
            "name": "*3",
            "function": "No function",
            "reference": false
          },
          {
            "name": "*2",
            "function": "No function",
            "reference": false
          }
        ],
        "phenotypes": [
          "Poor Metabolizer",
          "Intermediate Metabolizer",
          "Indeterminate",
          "Likely Intermediate Metabolizer",
          "Rapid Metabolizer",
          "Normal Metabolizer",
          "Ultrarapid Metabolizer",
          "Likely Poor Metabolizer"
        ],
        "drugs": [
          {
            "name": "amitriptyline",
            "cpicLevel": "A",
            "clinpgxLevel": "1A",
            "guideline": {
              "name": "CYP2D6, CYP2C19 and Tricyclic Antidepressants",
              "url": "https://www.clinpgx.org/guideline/PA166251445"
            }
          },
          {
            "name": "citalopram",
            "cpicLevel": "A",
            "clinpgxLevel": "1A",
            "pgxTesting": "Actionable PGx",
            "guideline": {
              "name": "CYP2D6, CYP2C19, CYP2B6, SLC6A4, HTR2A and Serotonin Reuptake Inhibitor Antidepressants",
              "url": "https://www.clinpgx.org/guideline/PA166251452"
            }
          },
          {
            "name": "clopidogrel",
            "cpicLevel": "A",
            "clinpgxLevel": "1A",
            "pgxTesting": "Actionable PGx",
            "guideline": {
              "name": "CYP2C19 and Clopidogrel",
              "url": "https://www.clinpgx.org/guideline/PA166251443"
            }
          },
          {
            "name": "escitalopram",
            "cpicLevel": "A",
            "clinpgxLevel": "1A",
            "pgxTesting": "Informative PGx",
            "guideline": {
              "name": "CYP2D6, CYP2C19, CYP2B6, SLC6A4, HTR2A and Serotonin Reuptake Inhibitor Antidepressants",
              "url": "https://www.clinpgx.org/guideline/PA166251452"
            }
          },
          {
            "name": "lansoprazole",
            "cpicLevel": "A",
            "clinpgxLevel": "1A",
            "pgxTesting": "Informative PGx",
            "guideline": {
              "name": "CYP2C19 and Proton Pump Inhibitors",
              "url": "https://www.clinpgx.org/guideline/PA166251441"
            }
          },
          {
            "name": "omeprazole",
            "cpicLevel": "A",
            "clinpgxLevel": "1A",
            "pgxTesting": "Informative PGx",
            "guideline": {
              "name": "CYP2C19 and Proton Pump Inhibitors",
              "url": "https://www.clinpgx.org/guideline/PA166251441"
            }
          },
          {
            "name": "pantoprazole",
            "cpicLevel": "A",
            "clinpgxLevel": "1A",
            "pgxTesting": "Actionable PGx",
            "guideline": {
              "name": "CYP2C19 and Proton Pump Inhibitors",
              "url": "https://www.clinpgx.org/guideline/PA166251441"
            }
          },
          {
            "name": "sertraline",
            "cpicLevel": "A",
            "clinpgxLevel": "1A",
            "guideline": {
              "name": "CYP2D6, CYP2C19, CYP2B6, SLC6A4, HTR2A and Serotonin Reuptake Inhibitor Antidepressants",
              "url": "https://www.clinpgx.org/guideline/PA166251452"
            }
          },
          {
            "name": "voriconazole",
            "cpicLevel": "A",
            "clinpgxLevel": "1A",
            "pgxTesting": "Informative PGx",
            "guideline": {
              "name": "CYP2C19 and Voriconazole",
              "url": "https://www.clinpgx.org/guideline/PA166251456"
            }
          },
          {
            "name": "brivaracetam",
            "cpicLevel": "B",
            "clinpgxLevel": "3",
            "pgxTesting": "Actionable PGx"
          },
          {
            "name": "clomipramine",
            "cpicLevel": "B",
            "clinpgxLevel": "1A",
            "guideline": {
              "name": "CYP2D6, CYP2C19 and Tricyclic Antidepressants",
              "url": "https://www.clinpgx.org/guideline/PA166251445"
            }
          },
          {
            "name": "dexlansoprazole",
            "cpicLevel": "B",
            "clinpgxLevel": "1A",
            "pgxTesting": "Informative PGx",
            "guideline": {
              "name": "CYP2C19 and Proton Pump Inhibitors",
              "url": "https://www.clinpgx.org/guideline/PA166251441"
            }
          },
          {
            "name": "doxepin",
            "cpicLevel": "B",
            "clinpgxLevel": "1A",
            "pgxTesting": "Informative PGx",
            "guideline": {
              "name": "CYP2D6, CYP2C19 and Tricyclic Antidepressants",
              "url": "https://www.clinpgx.org/guideline/PA166251445"
            }
          },
          {
            "name": "imipramine",
            "cpicLevel": "B",
            "clinpgxLevel": "1A",
            "guideline": {
              "name": "CYP2D6, CYP2C19 and Tricyclic Antidepressants",
              "url": "https://www.clinpgx.org/guideline/PA166251445"
            }
          },
          {
            "name": "trimipramine",
            "cpicLevel": "B",
            "clinpgxLevel": "1A",
            "guideline": {
              "name": "CYP2D6, CYP2C19 and Tricyclic Antidepressants",
              "url": "https://www.clinpgx.org/guideline/PA166251445"
            }
          },
          {
            "name": "carisoprodol",
            "cpicLevel": "B/C",
            "clinpgxLevel": "4",
            "pgxTesting": "Actionable PGx"
          },
          {
            "name": "clobazam",
            "cpicLevel": "B/C",
            "clinpgxLevel": "2A",
            "pgxTesting": "Actionable PGx"
          },
          {
            "name": "diazepam",
            "cpicLevel": "B/C",
            "clinpgxLevel": "3",
            "pgxTesting": "Informative PGx"
          },
          {
            "name": "duloxetine",
            "cpicLevel": "C",
            "guideline": {
              "name": "CYP2D6, CYP2C19, CYP2B6, SLC6A4, HTR2A and Serotonin Reuptake Inhibitor Antidepressants",
              "url": "https://www.clinpgx.org/guideline/PA166251452"
            }
          },
          {
            "name": "esomeprazole",
            "cpicLevel": "C",
            "clinpgxLevel": "3",
            "pgxTesting": "No Clinical PGx",
            "guideline": {
              "name": "CYP2C19 and Proton Pump Inhibitors",
              "url": "https://www.clinpgx.org/guideline/PA166251441"
            }
          },
          {
            "name": "flibanserin",
            "cpicLevel": "C",
            "pgxTesting": "Actionable PGx"
          },
          {
            "name": "fluoxetine",
            "cpicLevel": "C",
            "guideline": {
              "name": "CYP2D6, CYP2C19, CYP2B6, SLC6A4, HTR2A and Serotonin Reuptake Inhibitor Antidepressants",
              "url": "https://www.clinpgx.org/guideline/PA166251452"
            }
          },
          {
            "name": "fluvoxamine",
            "cpicLevel": "C",
            "guideline": {
              "name": "CYP2D6, CYP2C19, CYP2B6, SLC6A4, HTR2A and Serotonin Reuptake Inhibitor Antidepressants",
              "url": "https://www.clinpgx.org/guideline/PA166251452"
            }
          },
          {
            "name": "paroxetine",
            "cpicLevel": "C",
            "guideline": {
              "name": "CYP2D6, CYP2C19, CYP2B6, SLC6A4, HTR2A and Serotonin Reuptake Inhibitor Antidepressants",
              "url": "https://www.clinpgx.org/guideline/PA166251452"
            }
          },
          {
            "name": "rabeprazole",
            "cpicLevel": "C",
            "clinpgxLevel": "2A",
            "pgxTesting": "Informative PGx",
            "guideline": {
              "name": "CYP2C19 and Proton Pump Inhibitors",
              "url": "https://www.clinpgx.org/guideline/PA166251441"
            }
          },
          {
            "name": "venlafaxine",
            "cpicLevel": "C",
            "clinpgxLevel": "3",
            "guideline": {
              "name": "CYP2D6, CYP2C19, CYP2B6, SLC6A4, HTR2A and Serotonin Reuptake Inhibitor Antidepressants",
              "url": "https://www.clinpgx.org/guideline/PA166251452"
            }
          },
          {
            "name": "vortioxetine",
            "cpicLevel": "C",
            "guideline": {
              "name": "CYP2D6, CYP2C19, CYP2B6, SLC6A4, HTR2A and Serotonin Reuptake Inhibitor Antidepressants",
              "url": "https://www.clinpgx.org/guideline/PA166251452"
            }
          }
        ],
        "name": "Pharmacogenomics",
        "url": "https://dantelabs.com/whole-genome-sequencing/pharmacogenomics"
      }
    ],
    "traits": [],
    "phenotypes": [],
    "related": [],
    "sources": null,
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}