--- title: "APC L68Yfs*2 (c.203del, rs1756331894) | Dante Labs" description: "ClinVar classifies APC L68Yfs*2 as Pathogenic (reviewed by expert panel). Where it sits in the genome, its predicted effect, and the Genome Test reports that look at it." url: "https://dantelabs.com/genes/apc/variants/l68yfs2" --- 1. [Genes](https://dantelabs.com/genes) 2. [APC](https://dantelabs.com/genes/apc) 3. APC L68Yfs\*2 Variant # APC L68Yfs\*2 NM_000038.6(APC):c.203del (p.Leu68TyrfsTer2) Also known as - p.Leu68TyrfsTer2 - p.L68Yfs\*2 - rs1756331894 * ClinVar classification Pathogenic * Review status 3 stars out of 4 reviewed by expert panel * Last evaluated 19 May 2025 * Expert panel ClinGen InSiGHT Hereditary Colorectal Cancer/Polyposis Variant Curation Expert Panel Data current to ClinVar release 2026-10-12 · Dante Labs data release 2026.10.16-c6eea6bf Facts last changed 16 October 2026 ## Summary L68Yfs\*2 is a frameshift variant in APC: it adds or removes DNA letters in a way that shifts how the rest of the gene's code is read. ClinVar classifies it as pathogenic for familial adenomatous polyposis 1 (reviewed by expert panel). ## ClinVar classifications | Condition | Classification | Review status | Submissions | Last evaluated | | ----------------------------------------------------------------------------------------------------------------------------------- | -------------- | ----------------------------------------- | ------------ | -------------- | | familial adenomatous polyposis 1[ClinVar VCV000934724 (opens in a new tab)](https://www.ncbi.nlm.nih.gov/clinvar/variation/934724/) | Pathogenic | 3 stars out of 4 reviewed by expert panel | 1 submission | 19 May 2025 | Classifications as ClinVar records them in release 2026-10-12. ClinVar updates them as evidence is reviewed. ## Where it lies in APC L68Yfs\*2 lies in exon 3 of the 16 in APC's MANE Select transcript, NM_000038.6. [APC variants in exon 3 →](https://dantelabs.com/genes/apc/variants?exon=3) [APC's gene diagram →](https://dantelabs.com/genes/apc#gene-structure) ## Molecular details | Gene | [APC](https://dantelabs.com/genes/apc) | | --------------------------- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | | Transcript | NM_000038.6 MANE Select | | Coding DNA change (HGVS c.) | c.203del | | Protein change (HGVS p.) | p.Leu68TyrfsTer2 p.L68Yfs\*2 | | Predicted consequence | Frameshift [frameshift_variant (opens in a new tab)](https://purl.obolibrary.org/obo/SO_0001589) [frameshift_truncation (opens in a new tab)](https://purl.obolibrary.org/obo/SO_0001910) | | Predicted impact | High | | Position (GRCh38) | chr5:112766390 AT>A | | Position (GRCh37) | chr5:112102087 AT>A | | dbSNP ID | [rs1756331894 (opens in a new tab)](https://www.ncbi.nlm.nih.gov/snp/rs1756331894) | | ClinVar Variation ID | [VCV000934724 (opens in a new tab)](https://www.ncbi.nlm.nih.gov/clinvar/variation/934724/) | | ClinVar Allele ID | 932493 | | ClinGen Allele Registry ID | [CA1139658985 (opens in a new tab)](https://reg.clinicalgenome.org/redmine/projects/registry/genboree_registry/by_canonicalid?canonicalid=CA1139658985) | | ClinVar name | NM_000038.6(APC):c.203del (p.Leu68fs) | ## APC L68Yfs\*2 in other databases - [ClinVar VCV000934724 (opens in a new tab)](https://www.ncbi.nlm.nih.gov/clinvar/variation/934724/) - [dbSNP rs1756331894 (opens in a new tab)](https://www.ncbi.nlm.nih.gov/snp/rs1756331894) - [ClinGen Allele Registry CA1139658985 (opens in a new tab)](https://reg.clinicalgenome.org/redmine/projects/registry/genboree_registry/by_canonicalid?canonicalid=CA1139658985) - [gnomAD 5-112766390-AT-A (opens in a new tab)](https://gnomad.broadinstitute.org/variant/5-112766390-AT-A?dataset=gnomad_r4) - [Ensembl rs1756331894 (opens in a new tab)](https://www.ensembl.org/Homo_sapiens/Variation/Explore?v=rs1756331894) ## Reports that look at this variant (1) These Genome Test condition reports include L68Yfs\*2 among the variants they look at. | Report | Conditions | Inheritance | | --------------------------------------------------------------------------------------------- | ------------------------------------------------------ | ------------------ | | [Colorectal Cancer & Polyposis](https://dantelabs.com/conditions/colorectal-cancer-polyposis) | Familial adenomatous polyposis (classic or attenuated) | Autosomal dominant | ## Other variants in APC - [c.220+1G>A Pathogenic 3 stars out of 4](https://dantelabs.com/genes/apc/variants/c-220plus1g-a) - [c.220+2T>A Pathogenic 3 stars out of 4](https://dantelabs.com/genes/apc/variants/c-220plus2t-a) - [c.423-8A>G Likely pathogenic 3 stars out of 4](https://dantelabs.com/genes/apc/variants/c-423-8a-g) - [c.423-9A>G Likely pathogenic 3 stars out of 4](https://dantelabs.com/genes/apc/variants/c-423-9a-g) - [c.423-11A>G Likely pathogenic 3 stars out of 4](https://dantelabs.com/genes/apc/variants/c-423-11a-g) - [c.471G>A Pathogenic 3 stars out of 4](https://dantelabs.com/genes/apc/variants/c-471g-a) - [c.531+1_531+4del Likely pathogenic 3 stars out of 4](https://dantelabs.com/genes/apc/variants/c-531plus1to531plus4del) - [c.531+5G>AIVS5+5G>A Likely pathogenic 3 stars out of 4](https://dantelabs.com/genes/apc/variants/c-531plus5g-a) - [c.531+5G>C Likely pathogenic 3 stars out of 4](https://dantelabs.com/genes/apc/variants/c-531plus5g-c) - [c.531+6T>C Likely pathogenic 3 stars out of 4](https://dantelabs.com/genes/apc/variants/c-531plus6t-c) [All APC variants](https://dantelabs.com/genes/apc/variants) ## Limitations This page describes publicly available information about a genetic variant. It is not a diagnosis, and it says nothing about whether you or anyone else carries this variant. Classifications come from ClinVar and change as new evidence is reviewed. A classification here may differ from the one in ClinVar today, or from the one a laboratory reports. Whole genome sequencing with short reads can miss or miscall some variants, particularly in repeated or highly similar stretches of DNA and in large insertions, deletions or rearrangements. If you have questions about a variant in your own results or in your family, talk to a genetic counsellor or your doctor. ## Sources & credits - Classifications from ClinVar (release 2026-10-12), National Center for Biotechnology Information. - Condition terms from the Mondo Disease Ontology (release 2026-10-06), used under CC BY 4.0. - Gene symbols and names from the HUGO Gene Nomenclature Committee (release 2026-10-16). - Allele identifiers from the ClinGen Allele Registry (release 2026-10-16-c4908f54). - Reference SNP identifiers from dbSNP (release b157), National Center for Biotechnology Information. - Gene–disease links from the Gene Curation Coalition, GenCC (release 2026-10-16). - Difficult regions from the Genome in a Bottle Consortium (release v3.6). - Transcripts from MANE (release v1.5), NCBI and EMBL-EBI. - Predicted consequences from mehari (release 0.11.0), with transcript models from cdot. - Built from Dante Labs data release 2026.10.16-c6eea6bf of 16 October 2026. ## Cite this page APA > Dante Labs. (16 October 2026). APC L68Yfs\*2 (c.203del, rs1756331894) (Version 2026.10.16-c6eea6bf). Retrieved 16 October 2026, from https\://dantelabs.com/genes/apc/variants/l68yfs2 Vancouver > Dante Labs. APC L68Yfs\*2 (c.203del, rs1756331894) \[Internet]. Version 2026.10.16-c6eea6bf. 16 October 2026 \[cited 16 October 2026]. Available from: https\://dantelabs.com/genes/apc/variants/l68yfs2 Download citation [RIS](https://dantelabs.com/genes/apc/variants/l68yfs2/cite.ris) [BibTeX](https://dantelabs.com/genes/apc/variants/l68yfs2/cite.bib) [CSL-JSON](https://dantelabs.com/genes/apc/variants/l68yfs2/cite.json) ## Read your whole genome From $449 Free shipping · Results in 6–8 weeks [Explore the Genome Test](https://dantelabs.com/whole-genome-sequencing)