{
  "url": "https://dantelabs.com/traits/skin-nodule",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "skin-nodule",
    "id": "HP:0200036",
    "name": "Skin nodule",
    "definition": "Morphologically similar to a papule, but greater than either 10mm in both width and depth, and most frequently centered in the dermis or subcutaneous fat.",
    "synonyms": [
      "Growth of abnormal tissue on or under the skin"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-integument",
        "name": "Abnormality of the integument",
        "url": "https://dantelabs.com/traits/abnormality-of-the-integument"
      }
    ],
    "broader": [
      {
        "slug": "localized-skin-lesion",
        "name": "Localized skin lesion",
        "url": "https://dantelabs.com/traits/localized-skin-lesion"
      }
    ],
    "narrower": [
      {
        "slug": "subcutaneous-nodule",
        "name": "Firm lump under the skin",
        "genes": 81,
        "url": "https://dantelabs.com/traits/subcutaneous-nodule"
      },
      {
        "slug": "acrokeratosis",
        "name": "Acrokeratosis",
        "genes": 3,
        "url": "https://dantelabs.com/traits/acrokeratosis"
      },
      {
        "slug": "nodular-changes-affecting-the-eyelids",
        "name": "Eyelid nodules",
        "genes": 2,
        "url": "https://dantelabs.com/traits/nodular-changes-affecting-the-eyelids"
      },
      {
        "slug": "osteoma-cutis",
        "name": "Osteoma cutis",
        "genes": 1,
        "url": "https://dantelabs.com/traits/osteoma-cutis"
      }
    ],
    "genes": [
      {
        "slug": "mefv",
        "symbol": "MEFV",
        "hgnc": "HGNC:6998",
        "name": "MEFV innate immunity regulator, pyrin",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mefv"
      },
      {
        "slug": "ptpn6",
        "symbol": "PTPN6",
        "hgnc": "HGNC:9658",
        "name": "protein tyrosine phosphatase non-receptor type 6",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptpn6"
      },
      {
        "slug": "btnl2",
        "symbol": "BTNL2",
        "hgnc": "HGNC:1142",
        "name": "butyrophilin like 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/btnl2"
      },
      {
        "slug": "glmn",
        "symbol": "GLMN",
        "hgnc": "HGNC:14373",
        "name": "glomulin, FKBP associated protein",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/glmn"
      },
      {
        "slug": "hla-drb1",
        "symbol": "HLA-DRB1",
        "hgnc": "HGNC:4948",
        "name": "major histocompatibility complex, class II, DR beta 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/hla-drb1"
      },
      {
        "slug": "kit",
        "symbol": "KIT",
        "hgnc": "HGNC:6342",
        "name": "KIT proto-oncogene, receptor tyrosine kinase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kit"
      },
      {
        "slug": "porcn",
        "symbol": "PORCN",
        "hgnc": "HGNC:17652",
        "name": "porcupine O-acyltransferase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/porcn"
      },
      {
        "slug": "bcl2",
        "symbol": "BCL2",
        "hgnc": "HGNC:990",
        "name": "BCL2 apoptosis regulator",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bcl2"
      },
      {
        "slug": "bcl6",
        "symbol": "BCL6",
        "hgnc": "HGNC:1001",
        "name": "BCL6 transcription repressor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bcl6"
      },
      {
        "slug": "igh",
        "symbol": "IGH",
        "hgnc": "HGNC:5477",
        "name": "immunoglobulin heavy locus",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/igh"
      },
      {
        "slug": "pdgfrb",
        "symbol": "PDGFRB",
        "hgnc": "HGNC:8804",
        "name": "platelet derived growth factor receptor beta",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pdgfrb"
      },
      {
        "slug": "gjb2",
        "symbol": "GJB2",
        "hgnc": "HGNC:4284",
        "name": "gap junction protein beta 2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gjb2"
      },
      {
        "slug": "gjb6",
        "symbol": "GJB6",
        "hgnc": "HGNC:4288",
        "name": "gap junction protein beta 6",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gjb6"
      },
      {
        "slug": "asah1",
        "symbol": "ASAH1",
        "hgnc": "HGNC:735",
        "name": "N-acylsphingosine amidohydrolase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/asah1"
      },
      {
        "slug": "kif1b",
        "symbol": "KIF1B",
        "hgnc": "HGNC:16636",
        "name": "kinesin family member 1B",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kif1b"
      }
    ]
  }
}