{
  "url": "https://dantelabs.com/traits/prolonged-bleeding-time",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "prolonged-bleeding-time",
    "id": "HP:0003010",
    "name": "Prolonged bleeding time",
    "definition": "Prolongation of the time taken for a standardized skin cut of fixed depth and length to stop bleeding.",
    "synonyms": [
      "Increased bleeding time"
    ],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-bleeding",
        "name": "Bleeding tendency",
        "url": "https://dantelabs.com/traits/abnormal-bleeding"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "ap3b1",
        "symbol": "AP3B1",
        "hgnc": "HGNC:566",
        "name": "adaptor related protein complex 3 subunit beta 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ap3b1"
      },
      {
        "slug": "creb3l1",
        "symbol": "CREB3L1",
        "hgnc": "HGNC:18856",
        "name": "cAMP responsive element binding protein 3 like 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/creb3l1"
      },
      {
        "slug": "dtnbp1",
        "symbol": "DTNBP1",
        "hgnc": "HGNC:17328",
        "name": "dystrobrevin binding protein 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dtnbp1"
      },
      {
        "slug": "gfi1b",
        "symbol": "GFI1B",
        "hgnc": "HGNC:4238",
        "name": "growth factor independent 1B transcriptional repressor",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gfi1b"
      },
      {
        "slug": "gp6",
        "symbol": "GP6",
        "hgnc": "HGNC:14388",
        "name": "glycoprotein VI platelet",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gp6"
      },
      {
        "slug": "hps5",
        "symbol": "HPS5",
        "hgnc": "HGNC:17022",
        "name": "HPS5 biogenesis of lysosomal organelles complex 2 subunit 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hps5"
      },
      {
        "slug": "hps6",
        "symbol": "HPS6",
        "hgnc": "HGNC:18817",
        "name": "HPS6 biogenesis of lysosomal organelles complex 2 subunit 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hps6"
      },
      {
        "slug": "rasgrp2",
        "symbol": "RASGRP2",
        "hgnc": "HGNC:9879",
        "name": "RAS guanyl releasing protein 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rasgrp2"
      },
      {
        "slug": "rin2",
        "symbol": "RIN2",
        "hgnc": "HGNC:18750",
        "name": "Ras and Rab interactor 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rin2"
      },
      {
        "slug": "runx1",
        "symbol": "RUNX1",
        "hgnc": "HGNC:10471",
        "name": "RUNX family transcription factor 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/runx1"
      },
      {
        "slug": "thbs2",
        "symbol": "THBS2",
        "hgnc": "HGNC:11786",
        "name": "thrombospondin 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/thbs2"
      },
      {
        "slug": "calr",
        "symbol": "CALR",
        "hgnc": "HGNC:1455",
        "name": "calreticulin",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/calr"
      },
      {
        "slug": "gata2",
        "symbol": "GATA2",
        "hgnc": "HGNC:4171",
        "name": "GATA binding protein 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gata2"
      },
      {
        "slug": "itga2b",
        "symbol": "ITGA2B",
        "hgnc": "HGNC:6138",
        "name": "integrin subunit alpha 2b",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/itga2b"
      },
      {
        "slug": "itgb3",
        "symbol": "ITGB3",
        "hgnc": "HGNC:6156",
        "name": "integrin subunit beta 3",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/itgb3"
      },
      {
        "slug": "jak2",
        "symbol": "JAK2",
        "hgnc": "HGNC:6192",
        "name": "Janus kinase 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/jak2"
      },
      {
        "slug": "mpl",
        "symbol": "MPL",
        "hgnc": "HGNC:7217",
        "name": "MPL proto-oncogene, thrombopoietin receptor",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mpl"
      },
      {
        "slug": "sh2b3",
        "symbol": "SH2B3",
        "hgnc": "HGNC:29605",
        "name": "SH2B adaptor protein 3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sh2b3"
      },
      {
        "slug": "slc35a1",
        "symbol": "SLC35A1",
        "hgnc": "HGNC:11021",
        "name": "solute carrier family 35 member A1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc35a1"
      },
      {
        "slug": "tek",
        "symbol": "TEK",
        "hgnc": "HGNC:11724",
        "name": "TEK receptor tyrosine kinase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tek"
      },
      {
        "slug": "tet2",
        "symbol": "TET2",
        "hgnc": "HGNC:25941",
        "name": "tet methylcytosine dioxygenase 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tet2"
      },
      {
        "slug": "tp53",
        "symbol": "TP53",
        "hgnc": "HGNC:11998",
        "name": "tumor protein p53",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tp53"
      },
      {
        "slug": "was",
        "symbol": "WAS",
        "hgnc": "HGNC:12731",
        "name": "WASP actin nucleation promoting factor",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/was"
      },
      {
        "slug": "fyb1",
        "symbol": "FYB1",
        "hgnc": "HGNC:4036",
        "name": "FYN binding protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fyb1"
      },
      {
        "slug": "map2k2",
        "symbol": "MAP2K2",
        "hgnc": "HGNC:6842",
        "name": "mitogen-activated protein kinase kinase 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/map2k2"
      },
      {
        "slug": "myh9",
        "symbol": "MYH9",
        "hgnc": "HGNC:7579",
        "name": "myosin heavy chain 9",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/myh9"
      },
      {
        "slug": "myrf",
        "symbol": "MYRF",
        "hgnc": "HGNC:1181",
        "name": "myelin regulatory factor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/myrf"
      },
      {
        "slug": "nf1",
        "symbol": "NF1",
        "hgnc": "HGNC:7765",
        "name": "neurofibromin 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nf1"
      },
      {
        "slug": "aggf1",
        "symbol": "AGGF1",
        "hgnc": "HGNC:24684",
        "name": "angiogenic factor with G-patch and FHA domains 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aggf1"
      },
      {
        "slug": "bms1",
        "symbol": "BMS1",
        "hgnc": "HGNC:23505",
        "name": "BMS1 ribosome biogenesis factor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bms1"
      },
      {
        "slug": "col1a1",
        "symbol": "COL1A1",
        "hgnc": "HGNC:2197",
        "name": "collagen type I alpha 1 chain",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col1a1"
      },
      {
        "slug": "col5a1",
        "symbol": "COL5A1",
        "hgnc": "HGNC:2209",
        "name": "collagen type V alpha 1 chain",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col5a1"
      },
      {
        "slug": "col5a2",
        "symbol": "COL5A2",
        "hgnc": "HGNC:2210",
        "name": "collagen type V alpha 2 chain",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col5a2"
      },
      {
        "slug": "dll4",
        "symbol": "DLL4",
        "hgnc": "HGNC:2910",
        "name": "delta like canonical Notch ligand 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dll4"
      },
      {
        "slug": "itgb4",
        "symbol": "ITGB4",
        "hgnc": "HGNC:6158",
        "name": "integrin subunit beta 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/itgb4"
      },
      {
        "slug": "pik3ca",
        "symbol": "PIK3CA",
        "hgnc": "HGNC:8975",
        "name": "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pik3ca"
      },
      {
        "slug": "plec",
        "symbol": "PLEC",
        "hgnc": "HGNC:9069",
        "name": "plectin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plec"
      },
      {
        "slug": "uba2",
        "symbol": "UBA2",
        "hgnc": "HGNC:30661",
        "name": "ubiquitin like modifier activating enzyme 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/uba2"
      },
      {
        "slug": "cd36",
        "symbol": "CD36",
        "hgnc": "HGNC:1663",
        "name": "CD36 molecule (CD36 blood group)",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd36"
      },
      {
        "slug": "f2",
        "symbol": "F2",
        "hgnc": "HGNC:3535",
        "name": "coagulation factor II, thrombin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/f2"
      },
      {
        "slug": "f5",
        "symbol": "F5",
        "hgnc": "HGNC:3542",
        "name": "coagulation factor V",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/f5"
      },
      {
        "slug": "gata1",
        "symbol": "GATA1",
        "hgnc": "HGNC:4170",
        "name": "GATA binding protein 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gata1"
      },
      {
        "slug": "gp1ba",
        "symbol": "GP1BA",
        "hgnc": "HGNC:4439",
        "name": "glycoprotein Ib platelet subunit alpha",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gp1ba"
      },
      {
        "slug": "gp1bb",
        "symbol": "GP1BB",
        "hgnc": "HGNC:4440",
        "name": "glycoprotein Ib platelet subunit beta",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gp1bb"
      },
      {
        "slug": "gp9",
        "symbol": "GP9",
        "hgnc": "HGNC:4444",
        "name": "glycoprotein IX platelet",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gp9"
      },
      {
        "slug": "hps1",
        "symbol": "HPS1",
        "hgnc": "HGNC:5163",
        "name": "HPS1 biogenesis of lysosomal organelles complex 3 subunit 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hps1"
      },
      {
        "slug": "nbeal2",
        "symbol": "NBEAL2",
        "hgnc": "HGNC:31928",
        "name": "neurobeachin like 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nbeal2"
      },
      {
        "slug": "vwf",
        "symbol": "VWF",
        "hgnc": "HGNC:12726",
        "name": "von Willebrand factor",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/vwf"
      }
    ]
  }
}